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Application of the extract and composition of stinkbuckle in anti-influenza A virus medicine

A technology of viral influenza and extract, which is applied in the field of medicine, can solve the problems of viral influenza A, which has not been found in the extract of stink elixir

Active Publication Date: 2016-10-05
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report on the use of the extract of stinky dandelion for anti-influenza A virus

Method used

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  • Application of the extract and composition of stinkbuckle in anti-influenza A virus medicine
  • Application of the extract and composition of stinkbuckle in anti-influenza A virus medicine
  • Application of the extract and composition of stinkbuckle in anti-influenza A virus medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The extraction method of Culinary Pill extract: use Culinary Pill medicinal material, add 10 times the weight of Culinary Pill medicinal material in ethanol, methanol, acetone, ethyl acetate, and extract by cold soaking or percolation, reflux heating and ultrasonic extraction. The initial extract; the initial extract is treated as follows: add 2 times the weight of the initial extract, leave it for 2 hours, filter out the insoluble chlorophyll and resin, concentrate the water under reduced pressure, and add 2 times the amount of the concentrate Absolute ethanol, stand for 4 hours, filter out the alcohol insolubles; the alcohol solution repeats to remove the water insolubles again, or directly recover the solvent to dry to get the ozone extract; or the initial extract is placed on a macroporous resin column or activated carbon column and washed with water , Remove water-soluble impurities, and then eluted with 20%-95% ethanol, collect the ethanol eluate, and recover the so...

Embodiment 2

[0047] The culinary pill extract can be combined with Guanzhong, honeysuckle, and medicinal excipients to form a pharmaceutical composition. The parts by weight of each component are (kg): Chou Ling Dan extract 80, Guanzhong 10, honeysuckle 10, and necessary medicinal excipients (the amount can be prepared according to the prior art).

Embodiment 3

[0049] The parts by weight of each component of the medicinal composition of culinary pill extract are (kg): culinary pill extract 70, Guanzhong 15, honeysuckle 15, and necessary medicinal excipients (the amount can be prepared according to the prior art) .

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Abstract

The invention discloses application of a laggera pterodonta extract and a composition in a drug for resisting influenza A virus. The laggera pterodonta extract can strongly suppress the respiratory tract influenza A virus. Active ingredients of the laggera pterodonta extract are obtained by extracting a wingedtooth laggera herb or re-leaching, depositing and chromatographing with ethanol, methanol or a fat soluble solvent. A series of experiments including cytopathic effect, blood clotting titer, RealTime RT-PCR (Reverse Transcription-Polymerase Chain Reaction) and so on are performed to the laggera pterodonta extract, in order to detect influenza A virus in-vivo neutralization and anti-proliferative effect of the laggera pterodonta extract samples. The laggera pterodonta extract and the active ingredients have the anti-influenza A virus activity, and have a prospect of being developed to a single-preparation or composite drug for resisting the influenza A virus.

Description

Technical field [0001] The present invention relates to the technical field of medicine, in particular to the application of ozone extract and its composition in anti-virus influenza A drugs. Background technique [0002] Laggera Pterodonta (DC.) Benth is a medicinal plant of the genus Hexanthera in the Asteraceae family. It is also known as Lion's Grass, Stinky Leaf, Hexanthera, etc., distributed in Yunnan, Sichuan, Tibet and other places, mainly produced in Yunnan, my country Province, rich sources of medicine. "Yunnan Chinese Herbal Medicine", "Kunming Folk Common Herbs" and "Southern Yunnan Materia Medica" contain a large number of Yunnan folk's experience in the use of odorless pill. This medicine has good antibacterial, anti-inflammatory, heat-clearing and detoxifying effects, and is widely used to treat colds , Pharyngitis, bronchitis, malaria and other diseases. At present, the compounds identified from this genus are mainly eucalyptane-type sesquiterpenes and flavonols....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/355A61K36/28A61P31/16
Inventor 张荣平王新华夏晓玲孙强明杨子峰于浩飞潘锡平
Owner KUNMING MEDICAL UNIVERSITY
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