Composition for preventing and treating HIV/AIDS (Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome) and preparation method thereof

A composition and ginseng technology, applied in the field of traditional Chinese medicine, can solve the problems of low starting point, lack of scientific objective data on treatment effect, low investment and so on

Active Publication Date: 2014-05-07
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For more than 20 years, although the advent of antiviral western medicine and the use of Hart (HARRT) therapy have effectively inhibited virus replication, significantly reduced the morbidity and mortality of opportunistic infections, and improved the quality of life of patients, many problems are far from failed to resolve
[0005] There have been more than 20 years of research on traditional Chinese medicine anti-AIDS drugs. Hundreds of traditional Chinese medicines for clearing away heat and detoxification, promoting blood circulation

Method used

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  • Composition for preventing and treating HIV/AIDS (Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome) and preparation method thereof
  • Composition for preventing and treating HIV/AIDS (Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome) and preparation method thereof
  • Composition for preventing and treating HIV/AIDS (Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome) and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1）、TSZ11（ Embodiment 2

[0058] Drugs: TSZ10 (Example 1 of the present invention), TSZ11 (Example 2 of the present invention), TSZ12 (Example 3 of the present invention), 3TC (internal control), AZT (internal control)

[0059] Virus: HIV-1RF

[0060] Cell line: MT-4

[0061] Objective: To determine the anti-HIV-1 activity of the drug to be tested by cell virus experiment.

[0062] In the XTT cell virus experiment, living cells metabolize to produce XTT, so they have a high absorption value, and dead cells do not produce XTT, so the absorption value is still relatively low.

[0063] Drugs with antiviral effects protect HIV-infected cells from death caused by the virus and increase absorbance due to the production of XTT metabolites. Toxic drugs cause a large number of cells to die and produce less XTT, so the absorbance is still very low.

[0064] Preparation: Grind the drug into fine powder, dissolve it with DMSO to a concentration of 100 mg / ml, and dilute it to 10 mg / ml (10% DMSO) with medium-free...

Embodiment 1

[0114] Ginseng 129g Cordyceps 4g Angelica 148g Astragalus 148g Salvia 148g

[0115] Coix seed 148g Poria cocos 80g Rehmannia glutinosa 80g Burnt hawthorn 80g Burnt malt 80g

[0116] Jiao Shenqu 80g Licorice 80g

[0117] a) Weigh ginseng, cordyceps sinensis, angelica, astragalus, salvia miltiorrhiza, coix seed, poria cocos, rehmannia glutinosa, scorched hawthorn, scorched malt, scorched divine music, licorice;

[0118] b) Take 50% of ginseng and the whole amount of Cordyceps sinensis and pulverize them into fine powder to obtain fine powder I for subsequent use;

[0119] c) After soaking Angelica sinensis in water for 2 hours, extract the volatile oil for 6 hours, and collect the volatile oil in another device; the extracted medicinal residue is medicinal residue I, and the medicinal liquid after oil extraction is filtered to obtain medicinal liquid I, which is set aside;

[0120] d) Salvia miltiorrhiza and coix seed plus 6 times the amount of 95% ethanol, reflux extraction t...

Embodiment 2

[0124]Ginseng 80g Cordyceps 9g Angelica 100g Astragalus 200g Salvia 100g

[0125] Coix seed 200g Poria cocos 30g Rehmannia glutinosa 120g Burnt hawthorn 30g Burnt malt 120g

[0126] Jiao Shenqu 30g Licorice 120g

[0127] a) Weigh ginseng, cordyceps sinensis, angelica, astragalus, salvia miltiorrhiza, coix seed, poria cocos, rehmannia glutinosa, scorched hawthorn, scorched malt, scorched divine music, licorice;

[0128] b) Take 50% of ginseng and the whole amount of Cordyceps sinensis and pulverize them into fine powder to obtain fine powder I for subsequent use;

[0129] c) After soaking Angelica Angelica in water for 1 hour, extract the volatile oil for 7 hours, collect the volatile oil in another device, extract the medicinal residues as medicinal residues I, and filter the medicinal liquid after extracting the oil to obtain medicinal liquid I for later use;

[0130] d) Salvia miltiorrhiza and coix seed plus 4 times the amount of 80% ethanol to reflux extract 4 times, 0.5 ...

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Abstract

The invention discloses a composition for preventing and treating HIV/AIDS (Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome) and a preparation method thereof. The medicine composition comprises the following components by weight ratio: ginseng, cordyceps sinensis, angelica sinensis, astragalus membranaceus, root of red-rooted salvia, semen coicis, poria cocos, rehmannia, hawthorn, malt, medicated leaven and liquorice. The composition has the effects of reinforcing qi and nourishing blood, strengthening spleen and tonifying lung, can treat deficiency of qi and blood for patients suffering from AIDS and HIV infected persons, and can be used for symptoms such as physical and mental fatigue, qi deficiency and talk reluctance, poor appetite, spontaneous perspiration, easy cold, light-headedness, palpitation and insomnia, hand and foot numbness, and the like. The composition is prepared into any oral administration preparation, preferably tablets.

Description

technical field [0001] The invention relates to a composition for preventing and treating HIV / AIDS and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. Background technique [0002] AIDS (AIDS), also known as acquired immunodeficiency syndrome, is caused by human immunodeficiency virus (HIV) infection. With the rapid spread of HIV around the world, people are facing the serious threat of AIDS. The rate is so high that it is called "super cancer". For more than 20 years, although the advent of antiviral western medicine and the use of Hart (HARRT) therapy have effectively inhibited virus replication, significantly reduced the morbidity and mortality of opportunistic infections, and improved the quality of life of patients, many problems are far from failed to resolve. [0003] Since the first AIDS patient was discovered in the United States in 1981, about 70 million people have been found to be infected with HIV around the worl...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61P31/18
Inventor 田圣勋张宏
Owner BEIJING INCREASEPHARM CORP LTD
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