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A pharmaceutical composition for treating osteoarthritis and its preparation method and application

A bone joint and composition technology, applied in drug combination, bone disease, pharmaceutical formula, etc., can solve problems such as adverse reactions, difficult to overcome toxic side effects, liver and blood system damage, and achieve good therapeutic effect

Inactive Publication Date: 2016-05-11
李兴富
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Regarding their effects, doctors and patients have different opinions, but it cannot be ignored that these drugs have insurmountable toxic and side effects
Because the above drugs inhibit the production of COX-1 and COX-2 at the same time, it leads to many serious adverse reactions, the most prominent ones are gastrointestinal complications, stomach discomfort and gastric bleeding, ulcers, perforation, and kidney, liver, blood system damage

Method used

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  • A pharmaceutical composition for treating osteoarthritis and its preparation method and application
  • A pharmaceutical composition for treating osteoarthritis and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh 60 parts of curculigo, 60 parts of mistletoe, 60 parts of Wulingzhi, 40 parts of Duhuo, 40 parts of Dipsacus, 30 parts of Fangfeng, 30 parts of ground beetle, 30 parts of curcuma, 30 parts of Sanleng, 30 parts of frankincense, 30 parts of medicine, 30 parts of Chuan Achyranthes bidentata, 10 parts of Radix Aconiti, 10 parts of Zhichuan Aconitum, 10 parts of Zhicaowu, 10 parts of Zhi Licorice, 5 parts of Scorpion, and 5 parts of Centipede. Mix Curculigo, Mistletoe, Wulingzhi, Duhuo, Dipsacus, Fangfeng, Ground Beetle, Curcuma, Sanleng, Achyranthes Achyranthes, Aconite Radix, Zhichuan Aconitum, Zhicaowu, Zhilicorice, add and mix evenly, Add 8 to 10 times the amount of medicinal materials in water and soak for 1 to 2 hours, then decoct for 2 to 2.5 hours, filter to obtain a decoction, and then concentrate it into an extract; mix frankincense, myrrh, scorpion, and centipede and grind them into granules Then add it to the concentrated extract; then dry the extract to ob...

Embodiment 2

[0029] Weigh 60 parts of curculigo, 60 parts of mistletoe, 60 parts of Wulingzhi, 40 parts of Duhuo, 40 parts of Dipsacus, 30 parts of Fangfeng, 30 parts of ground beetle, 30 parts of curcuma, 30 parts of Sanleng, 30 parts of frankincense, 30 parts of medicine, 30 parts of Sichuan Achyranthes bidentata, 5 parts of Radix Aconiti, 5 parts of Zhichuan Aconitum, 5 parts of Zhicaowu, 5 parts of Zhilicorice, 1 part of Scorpion, and 1 part of Centipede. Mix Curculigo, Mistletoe, Wulingzhi, Duhuo, Dipsacus, Fangfeng, Ground Beetle, Curcuma, Sanleng, Achyranthes Achyranthes, Aconite Radix, Zhichuan Aconitum, Zhicaowu, Zhilicorice, add and mix evenly, Add 8 to 10 times the amount of medicinal materials in water and soak for 1 to 2 hours, then decoct for 2 to 2.5 hours, filter to obtain a decoction, and then concentrate it into an extract; mix frankincense, myrrh, scorpion, and centipede and grind them into granules Then add it to the concentrated extract; then dry the extract to obtain ...

Embodiment 3

[0031] Weigh 50 parts of curculigo, 50 parts of mistletoe, 50 parts of Wulingzhi, 40 parts of Duhuo, 40 parts of Dipsacus, 30 parts of Fangfeng, 30 parts of ground beetle, 30 parts of curcuma, 30 parts of Sanleng, 20 parts of frankincense, 20 parts of medicine, 20 parts of Chuan Achyranthes bidentata, 10 parts of Radix Aconiti, 10 parts of Zhichuan Aconitum, 10 parts of Zhicaowu, 10 parts of Zhi Licorice, 5 parts of Scorpion, and 5 parts of Centipede. Mix Curculigo, Mistletoe, Wulingzhi, Duhuo, Dipsacus, Fangfeng, Ground Beetle, Curcuma, Sanleng, Achyranthes Achyranthes, Aconite Radix, Zhichuan Aconitum, Zhicaowu, Zhilicorice, add and mix evenly, Add 8 to 10 times the amount of medicinal materials in water and soak for 1 to 2 hours, then decoct for 2 to 2.5 hours, filter to obtain a decoction, and then concentrate it into an extract; mix frankincense, myrrh, scorpion, and centipede and grind them into granules Finally, add it to the concentrated extract; then dry the extract t...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating osteoarthropathy. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 30-60 parts of Curculigo orchioides, 30-60 parts of Viscum coloratum, 30-60 parts of Trogopterus xanthipes dung, 20-40 parts of Angelica pubescens, 20-40 parts of Dipsacus asperoides, 10-30 parts of Saposhnikovia divaricata, 10-30 parts of Eupolyphaga Seu Steleophaga (Eupolyphaga sinensis and / or Steleophaga plancyi), 10-30 parts of Rhizoma Curcumae, 10-30 parts of Sparganium stoloniferum, 10-30 parts of Olibanum, 10-30 parts of Myrrha, 10-30 parts of Cyathula officinalis, 5-10 parts of Typhonium giganteum, 5-10 parts of processed Aconitum carmichaeli (Radix Aconiti), 5-10 parts of processed Aconitum kusnezoffii, 5-10 parts of processed Radix Glycyrrhizae, 1-5 parts of Buthus martensii, and 1-5 parts of Scolopendra subspinipes. The pharmaceutical composition is prepared from traditional Chinese medicinal materials, has effects of expelling wind and removing dampness, strengthening bones and tendons, softening hard masses, dispelling cold and smoothing collaterals, has distinct analgesic, anti-inflammatory and repercussive effects, has no toxic and adverse side effect after long-term administration and low drug tolerance, and can effectively treat injury of meniscus articularis, rheumatic gonitis, degenerative gonitis, and other diseases. The invention also discloses a preparation method and application of the pharmaceutical composition.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating bone and joint diseases, a preparation method and application thereof. Background technique [0002] The meniscus is a layer of fibrocartilage located in the space of the knee joint, which plays an important role in joint function. The shape of the meniscus enables the spherical femoral condyle and the relatively flat tibial plateau to form a relatively "matching" joint. Its shape is about It is half moon, hence the name meniscus. The meniscus has the following important functions: increasing the stability of the knee joint, buffering, absorbing, and distributing the load force of the knee joint, and promoting nutrition in the joint. During weight-bearing, about 70% of the weight-bearing area is on the meniscus, which greatly reduces the stress on the tibial plateau, thereby protecting the cartilage and joints of the whole body. In addition, the meniscus also has the function of lubri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P19/02A61P19/04A61K35/24A61K35/64A61K35/646A61K35/648
Inventor 李兴富
Owner 李兴富
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