Improved FDG synthesis method

Abstract

The invention relates to an improved FDG (2-fluoro-2-deoxy-D-glucose) synthesis method. The method comprises the following steps: 1, leaching: eluting <18>F<-> with a potash / K2.2.2 / acetonitrile mixed solution; 2, drying: adding an HPLC acetonitrile solution, uniformly mixing, and drying at 121-123DEG C; 3, a fluorination reaction: adding a mannose triflate / anhydrous acetonitrile solution, and heating under a closed condition to carry out a fluorination reaction; 4, hydrolysis: adding an NaOH solution after the fluorination reaction to carry out hydrolysis; and 5, purifying transfer: adding an HCl solution and disinfected injection water for purifying transfer, wherein a volume ratio of the potash / K2.2.2 / acetonitrile mixed solution in step 1 to the HPLC acetonitrile solution in step 2 is 1.5:2, and a volume ratio of the HCl solution in step 5 and the disinfected injection water in the step 5 is 1.5:11. Compared with the prior art, the method provided by the invention has the advantages of simple operation, high synthesis efficiency, high stability and the like.

Description

technical field [0001] The invention relates to a synthesis method, in particular to an improved FDG synthesis method. Background technique [0002] 18 F-FDG refers to fluorodeoxyglucose, its complete chemical name is 2-fluoro-2-deoxy-D-glucose, usually abbreviated as FDG. [0003] Glucose is one of the three major energy substances in the human body, and it will be detected by PET and form an image of the positron nuclide 18 F is labeled on glucose, i.e. 18 f - Deoxyglucose ( 18 FDG). because 18 FDG can accurately reflect the glucose metabolism level of organs / tissues in the body, so it is known as the "molecule of the century" and is currently the main imaging agent for PET-CT imaging. [0004] Due to the vigorous metabolism of malignant tumor cells, the demand for glucose increases. Therefore, after intravenous injection of glucose analogue - 18FDG, most tumor lesions will show high uptake of 18FDG, so 18FDG PET-CT imaging can be used for early detection The prima...

AI Technical Summary

Problems solved by technology

Equipped with multiple independent FDG synthesizers, which greatly increases the production cost

Moreover, since FDG synthesis is carried out under radioactive conditions, the relevant equipment needs to be placed under 60mm lead protection, that is, each set of synthesis equipment has an independent synthesis protection box, so that its production cost is increased again

And the idleness of multiple devices will cause great waste

(2) Develop multiple synthesis techniques under the same module, that is, one charge under the same synthesizer and multiple synthesis. The advantage of this system is that it allows secondary synthesis in the case of radioactivity. When it cannot be more than twice, for Hospitals or companies that use a large amount still cannot meet the requirements

[0006] When it uses a lot of steps in the synthetic method, there are usually 28 steps, and the synthetic efficiency is low