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Method for obtaining nuclear magnetic resonance two-dimensional J-resolved spectroscopy in non-uniform magnetic field

A nuclear magnetic resonance and uniform magnetic field technology, applied in the measurement of magnetic variables, measurement devices, instruments, etc., can solve problems such as non-ideal magnetic field environment and application limitations

Inactive Publication Date: 2014-06-25
XIAMEN UNIV
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Problems solved by technology

The existing methods for improving the uniformity of the magnetic field (including hardware and software) have many limitations in application, such as the need to obtain the magnetic field distribution in advance, etc.
[0004] Although there have been a series of hardware or software shim...

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  • Method for obtaining nuclear magnetic resonance two-dimensional J-resolved spectroscopy in non-uniform magnetic field
  • Method for obtaining nuclear magnetic resonance two-dimensional J-resolved spectroscopy in non-uniform magnetic field
  • Method for obtaining nuclear magnetic resonance two-dimensional J-resolved spectroscopy in non-uniform magnetic field

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specific Embodiment

[0040] A biological tissue is scanned by this new method as an example, and this specific example is used to verify the feasibility of the present invention applied in an inhomogeneous magnetic field environment, especially in biological tissue. The sample used in the experiment was pig brain tissue, and the experimental test was carried out under a Varian 500MHz NMR spectrometer (Varian, Palo Alto, CA). There was no artificial shimming operation during the whole experimental process. According to the operation process of the intermolecular single-quantum two-dimensional J-decomposition method, firstly, a one-dimensional spectrum is obtained by sampling with a simple one-dimensional pulse sequence, and the sampling time is 2s. The result is as follows figure 2 As shown, the spectral line width can be obtained from this one-dimensional spectrum is 120Hz. Because the sample is directly sampled without shimming operation, the uniformity of the magnetic field is low. The 0.7-4.2...

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Abstract

The invention discloses a method for obtaining nuclear magnetic resonance two-dimensional J-resolved spectroscopy in a non-uniform magnetic field, and relates to a nuclear magnetic resonance spectrometer. The method comprises the steps that a piece of one-dimensional spectroscopy is sampled through a general one-dimensional pulse sequence, the line width of a spectral line is obtained, the basis is provided for spectral width parameter setting, and the line width reflects the magnetic field environment uniformity condition; (2) an intermolecular single-quantum coherent two-dimensional J-resolved spectroscopy pulse sequence which is compiled in advance is led to the nuclear magnetic resonance spectrometer; (3) an intermolecular single-quantum coherent signal selection module, an indirect dimension evolution period t1 module, an indirect dimension evolution period t2 module and a signal sampling period t3 module of the intermolecular single-quantum coherent two-dimensional J-resolved spectroscopy pulse sequence are opened, and experiment parameters of the modules of the intermolecular single-quantum coherent two-dimensional J-resolved spectroscopy pulse sequence are set; (4) the intermolecular single-quantum coherent two-dimensional J-resolved spectroscopy pulse sequence with the experiment parameters set in the step (3) is executed, and data sampling is carried out; (5) after data sampling is accomplished, related data post-processing is carried out to obtain the high-resolution two-dimensional J-resolved spectroscopy free from influence of the non-uniform magnetic field.

Description

technical field [0001] The invention relates to a nuclear magnetic resonance (NMR, Nuclear Magnetic Resonance) spectrometer, in particular to a method for obtaining a two-dimensional J-decomposition spectrum of nuclear magnetic resonance under an inhomogeneous magnetic field. Background technique [0002] Two-dimensional J-resolved spectroscopy (2D JRES) is one of the first two-dimensional spectroscopy methods proposed in the field of nuclear magnetic resonance. Its pulse sequence can be expressed as (π / 2)-t 1 / 2-(π / )-t 1 / 2+t 2 , consisting of a π / 2 pulse, a π pulse, and an indirect dimensional evolution period t divided in half 1 and a sampling period t 2 constitute. This conventional J decomposition spectrum method was first proposed by Ernst in 1976 (Aue W.P., Karhan J., and Ernst R.R. Two-dimensional spectroscopy application to nuclear magnetic resonance[J].J.Chem.Phys.,1976,64 , 2229-2246). In the two-dimensional J-decomposition spectrum, the chemical shift and ...

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Application Information

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IPC IPC(8): G01R33/387
Inventor 黄玉清陈忠
Owner XIAMEN UNIV
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