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Anti-aging activity of novel chalcone compound

A compound, anti-aging technology, applied in the fields of organic active ingredients, antidote, organic chemistry, etc.

Inactive Publication Date: 2014-07-23
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no research report on chalcone drugs that exert anti-aging effects from multiple levels. After long-term and arduous research experiments, the inventors designed and synthesized a series of chalcone compounds, which were tested for pharmacological activity. They were found to have good antiaging activity

Method used

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  • Anti-aging activity of novel chalcone compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Anti-aging activity verification of compounds on the cellular level in Example 1

[0023] Compound A322 was formulated into 3, 10, and 30 μM solutions with DMSO, respectively, and subconfluent rat cardiomyocytes H9c2(2-1) and human umbilical vein endothelial cells HUVEC-12 were inoculated on cell culture plates for 48 hours, and then added The above-mentioned different concentrations of active compound samples were intervened for 2 hours, and then H9c2(2-1) cells were added with 160 μM H 2 o 2 Treated for 2 hours and replaced with normal culture medium to continue culturing for 72 hours; at the same time, HUVEC-12 cells were added with 100 μM H 2 o 2 After 48 hours of treatment, they were also replaced with normal culture medium to continue culturing for 10 days, and the culture medium was replaced every 2 days. Evaluate the aging state of cells by observing the activity of β-galactosidase, aspirate the culture medium of the above two kinds of cells, wash with PBS, f...

Embodiment 2

[0027] Example 2 Research on Anti-aging Mechanism of Compound A322

[0028] 1. Determination of cell survival rate by MTT method: Take HUVEC-12 cells in the logarithmic growth phase, inoculate them in 96-well culture plates, and place them in a place containing 5% CO 2Cultured in a constant temperature incubator at 37°C for 24 hours. After the cells were completely adhered to the wall, 100 μl of the sample solution to be tested at different concentrations (3, 10 and 30 μM) were added to each well. At the same time, a blank control with only complete medium but no cells was set up. group and the positive control group (resveratrol, 30 μM), and each group had four replicate wells in parallel. After culturing for 48 hours, add 20 μl (5 mg / mL) of MTT solution to each well, continue to cultivate for 4 hours, discard the culture medium, and add 100 μl DMSO to each well. After the crystals are completely dissolved, measure the absorbance at 570 nm with a microplate reader, and calcul...

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Abstract

The invention provides a novel chalcone compound with anti-aging action. The novel chalcone compound can be applied to preparation of various dosage forms of crude drugs of related drugs for delaying senescence, or immune adjustment and promoting brain function, and can be applied to medical application of treatment of diseases related to senescence.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, in particular, the invention relates to the chemical structure of a novel chalcone compound with anti-aging effect. In addition, the present invention also relates to the anti-aging mechanism and application of the compound. Background technique [0002] Aging is a degenerative change in the functions of various tissues and organs of the body with age, a comprehensive manifestation of various biochemical reactions in the body, and the result of the joint action of many internal and external factors (environmental pollution, mental stress, genetics, etc.). With the continuous development of the population aging trend in the world, especially in our country, anti-aging, a worldwide medical topic, is also receiving increasing attention in our country. In recent years, the study of aging and the search for efficient anti-aging drugs based on the mechanism of aging have become hot issues in the fie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C225/22A61K31/136A61P37/02A61P25/28A61P39/00
Inventor 王艳艳张淑香牛雯颖于爽
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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