Super maduramicin and synthesis method thereof
A technology of maduramycin and its synthesis method, which is applied in the direction of chemical instruments and methods, drug combinations, and pharmaceutical formulations, and can solve problems such as increased technical difficulty, narrow use target range, and ineffective and rational use of high-quality products, achieving The effect of expanding the scope of application
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Embodiment 1
[0024] Super Maduramycin, its structural formula is as follows:
[0025] .
[0026] The synthetic method of above-mentioned super maduramycin, it comprises the following steps:
[0027] Accurately weigh 50g of maduramycin and 80ml of glacial acetic acid into a 1000ml three-necked flask, mix and stir for 2min at room temperature, and slowly add 116ml of acetic anhydride at a temperature of 5°C within 5min. Another 0.5ml of MSA was diluted with 8ml of glacial acetic acid and added to the three-necked flask within 10min. The temperature was raised to 60°C and the reaction was stirred for 50 min. After the reaction is over, pour the product into deionized water while stirring (the volume ratio of product to deionized water is 1:10), filter, wash the filter cake with deionized water to remove residual impurities and MSA, and then vacuum at 60°C After drying to constant weight, 51.3 g of white super maduramycin crystals were obtained.
Embodiment 2
[0029] Super Maduramycin, its structural formula is as follows:
[0030] .
[0031] The synthetic method of above-mentioned super maduramycin, it comprises the following steps:
[0032] Accurately weigh 50g of maduramycin and 80ml of glacial acetic acid into a 1000ml three-necked flask, mix and stir for 2min at room temperature, and slowly add 116ml of acetic anhydride at a temperature of 5°C within 5min. Another 0.5ml of MSA was diluted with 8ml of glacial acetic acid and added to the three-necked flask within 10min. The temperature was raised to 65°C and the reaction was stirred for 60 min. After the reaction, the product was poured into deionized water while stirring (the volume ratio of product to deionized water was 1:10), filtered, the filter cake was washed with deionized water, and then vacuum-dried at 60°C to constant weight to obtain 53.6g white super maduramycin crystals.
Embodiment 3
[0034] Super Maduramycin, its structural formula is as follows:
[0035] .
[0036] The synthetic method of above-mentioned super maduramycin, it comprises the following steps:
[0037] Accurately weigh 50g of maduramycin and 80ml of glacial acetic acid into a 1000ml three-necked flask, mix and stir for 2min at room temperature, and slowly add 116ml of acetic anhydride at a temperature of 5°C within 5min. Another 1ml of MSA was diluted with 8ml of glacial acetic acid and added to the three-necked flask within 10min. The temperature was raised to 65°C and the reaction was stirred for 60 min. After the reaction, the product was poured into deionized water while stirring (the volume ratio of product to deionized water was 1:10), filtered, the filter cake was washed with deionized water, and then vacuum-dried at 60°C to constant weight to obtain 52.4g white super maduramycin crystals.
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