49 results about "Coccidioses" patented technology

The invention discloses a sheep coccidiosis parasitic ovum accurate detection method based on deep learning, and the method comprises the following steps: automatically collecting a sheep manure sample image, carrying out the noise removal and enhancement of the image, and guaranteeing the image quality; the preprocessed image is input into an automatic sheep coccidiosis parasitic ovum detection model for training, the training process comprises image segmentation, feature extraction and accurate recognition, and a deep learning model is used for automatically recognizing sheep coccidiosis parasitic ovum; performing infection density analysis according to the number of sheep coccidiosis parasitic ova output by the improved deep learning model, and evaluating the infection risk of the sheep flock; the detection result is visually displayed, detailed analysis reports including the number, type distribution and infection density data of sheep coccidiosis parasitic ova are generated, hours or even longer time needed by a traditional method is shortened, and high accuracy of the detection result is ensured.

Disclosed are novel pharmaceutical, animal feed compositions and methods of treating non-human animals comprising at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s), or mixtures thereof, derived from non-woody plants of the genus Hesperaloe. Animal feed compositions may comprise a basal animal feed and water soluble solids extracted from Hesperaloe and comprising at least one saponin. The water soluble solids may comprise from about 5 to about 30 wt % saponin. The compositions of the present invention can be used for the treatment of non-human animals, such as poultry and more particularly for preventing and treating coccidiosis. An embodiment provides an immunological composition useful for inducing the production of antibodies to an antigen in a non-human animal comprising an antigen, preferably a coccidia, and a saponin composition extracted from Hesperaloe. The saponins extracted from Hesperaloe biomass may comprise 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside C, furcreastatin and yuccaloiside C.

The invention relates to the technical field of intelligent breeding, bioinformatics and artificial intelligence crossing, provides a chicken coccidiosis early warning method, device and equipment, a storage medium and a program product, and has relatively high anti-interference capability during chicken coccidiosis early warning. The voiceprint feature vector and the posture feature vector of the chicken are obtained according to the sound wave data and the video data in the current time window, so that the disease posterior probability and the group infection index are obtained; inputting the group infection index into a preset chicken coccidiosis SIR-Coccidia propagation dynamical model to carry out epidemic situation evolution simulation of a future time step; and when the epidemic situation evolution simulation result exceeds a preset safety threshold, generating a preliminary prevention and control strategy based on a multi-objective optimization algorithm, performing compliance matching processing on the preliminary prevention and control strategy and a preset veterinary prevention and control knowledge base, obtaining a corrected prevention and control strategy, performing risk prediction, and generating a target early warning instruction set.

The present disclosure provides a method of reducing, preventing or treating an intestinal infection, preventing or treating a disease associated with protozoan parasite of the genus Eimeria, inhibiting an oocyst sporulation of a protozoan parasite or preventing a sporozoite invasion or reproduction, preventing or treating coccidiosis, promoting growth performance, controlling, treating and / or preventing necrotic enteritis in a subject, comprising administering to the subject an effective amount of a composition comprising a Crassocephalum rabens (CR), a bioactive extract thereof (CRE), an active ingredient(s) contained in a CR (CR_API) or CRE (CRE_API), a combination of two or more of a CR, a CRE, a CR_API and a CRE_API, or one or more of a-linolenic acid, citric acid, lactic acid, mannitol, palmitic acid, aspartic acid and 1-monomyristin.

Developed and provided are: an anticoccidial agent, and a using method thereof, where the anticoccidial agent has an excellent anticoccidial activity and can eliminate or minimize mass outbreak of coccidioses. Thus, provided are: an anticoccidial agent containing, as an active ingredient, a benzimidazole compound represented by General Formula (1), or a salt of the compound, and a method for using the agent. General Formula (1) is expressed as follows:wherein R1 typically represents haloalkyl; X typically represents oxygen; R typically represents alkyl; Y represents halogen; m denotes 0 or 1; Z represents alkyl or halogen; and n denotes 0, 1, or 2.

The application relates to the technical field of animal disease prevention and control, and discloses a dynamic prevention and control method and system for chicken coccidiosis, which comprises the following steps: step 1: acquiring environmental parameter data, excrement hyperspectral data and chicken group behavior image data; step 2: processing the environmental parameter data, the excrement hyperspectral data and the chicken group behavior image data to obtain a micro-ecological state tensor; step 3: performing dynamic embedding and reasoning by using a graph attention network to obtain a pathogenicity coefficient of a pathogen, a host susceptibility index and a drug resistance evolution factor; step 4: inputting the pathogenicity coefficient of the pathogen, the host susceptibility index and the drug resistance evolution factor into a digital twin model to output an intestinal lesion score value, a drug resistance risk value and a predicted coccidial oocyst density value; and step 5: inputting the intestinal lesion score value, the drug resistance risk value and the predicted coccidial oocyst density value into a machine learning algorithm to generate a prevention and control strategy.

The present invention relates to a composition for use in the treatment and / or prevention of coccidiosis-induced conditions in poultry, wherein the composition comprises guanidinoacetic acid, guanidinoacetate or a mixture of any of these.

Developed and provided are: an anticoccidial agent, and a using method thereof, where the anticoccidial agent has an excellent anticoccidial activity and can eliminate or minimize mass outbreak of coccidioses. Thus, provided are: an anticoccidial agent containing, as an active ingredient, a benzimidazole compound represented by General Formula (1), or a salt of the compound, and a method for using the agent. General Formula (1) is expressed as follows:wherein R1 typically represents haloalkyl; X typically represents oxygen; R typically represents alkyl; Y represents halogen; m denotes 0 or 1; Z represents alkyl or halogen; and n denotes 0, 1, or 2.

The invention relates to the technical field of anticoccidial drugs, in particular to an anticoccidial preparation containing nicarbazin and a preparation method of the anticoccidial preparation. The anticoccidial preparation containing nicarbazin comprises the following raw materials in parts by mass: 3-7 parts of nicarbazin, 6-14 parts of monensin, 5-10 parts of mesoporous silica, 1-3 parts of chitosan, 1-2 parts of soybean lecithin, 0.1-0.5 part of carboxyl-terminated polyamidoamine, 1-2 parts of an emulsifier, 1-2 parts of a film-forming agent, 1-3 parts of a dispersant and 20-30 parts of vegetable oil. According to the present invention, the bioavailability is effectively improved, the problem of overhigh or overlow local drug concentration is overcome, the poultry can be prevented from being easily poisoned after ingestion, the treatment effect can be improved, the coccidiosis prevention and treatment effect is significant, the poultry growth is effectively promoted, the production cost is effectively reduced, and the batch production and the large-area promotion are easily achieved.

The invention discloses a composition for improving disease resistance of bred animals and a preparation method thereof, the composition comprises 5-15 parts by weight of toltrazuril, 0.5-1.5 parts by weight of a suspending aid, 1.5-2 parts by weight of a surfactant, 0.1-0.5 part by weight of an antioxidant, 5-10 parts by weight of plant polysaccharide, 20-35 parts by weight of dandelion, 10-25 parts by weight of purslane and 10-15 parts by weight of radix stemonae. The health-care food is prepared from, by weight, 10-20 parts of honeysuckle flowers, 1-2 parts of multivitamins, 1-2 parts of mineral substances and 1-5 parts of amino acid. The traditional Chinese medicine composition is prepared by scientific compatibility and reasonable collocation of various components. The toltrazuril component can effectively prevent the harm of coccidiosis to feed animals, not only can enhance the immunity of the fed animals, but also can promote the growth of the fed animals, saves resources, is easy to control, and is suitable for mass production.

The invention discloses a medicine mixing and feeding device for treating coccidiosis of black-bone chickens and enhancing immunity, which comprises a moisture-proof sealed medicine bin and a mixing kettle, a discharge pipe is arranged in the mixing kettle, and a discharge hole is formed in the side wall of the bottom of the discharge pipe in a penetrating manner; the mixing mechanism comprises a top plate fixedly connected to the top of the mixing kettle, the top plate is a circular plate, a rotating groove is coaxially formed in the lower surface of the top plate, a rotating plate is rotationally arranged in the rotating groove, a stirring mechanism control mechanism is connected to the lower surface of the rotating plate, and the mixing mechanism comprises a movable pipe arranged outside the discharging pipe in a sleeving and sliding mode; the mixing kettle is arranged, the discharging pipe is arranged in the mixing kettle to form the annular cavity, medicines are mixed in the annular cavity, accumulation is reduced, the mixing effect is better, the rotating plate is arranged to drive the stirring mechanism to stir the medicines in the annular cavity, stirring is more uniform, the discharging port is formed in the bottom of the discharging pipe, and the stirring effect is better. And discharging is controlled through movement of the movable pipe.

Avian coccidiosis is a disease caused by an intracellular parasitic protozoan of the genus Eimeria, which induces lesions in the gastrointestinal tissues of birds due to its replication. The process of qualifying an oocyst is almost entirely manual, using, in particular, the optical microscope counting technique, in which each identified object must be classified as sporulated or non-sporulated, stained or unstained. For the identification process, the method used is PCR (polymerase chain reaction), in which the presence of each species is detected, but without identifying each oocyst. This manual process is time-consuming and susceptible to errors. The method proposed herein introduces a computer vision model, based on Artificial Intelligence, capable of automating this classification process. The model analyzes samples and provides quantitative results, including the classification of oocysts into the categories of sporulated, non-sporulated, stained, and unstained, as well as the identification of Eimeria species (acervulina, brunetti, maxima, mitis, necatrix, praecox, or tenella). This computational model is entirely based on machine learning and is capable of identifying the presence of oocysts in a sample (image), classifying each identified oocyst into categories such as sporulated or non-sporulated, stained or unstained, quantifying the objects in each category, and identifying the Eimeria species.

The invention discloses a traditional Chinese medicine composition for resisting chicken coccidiosis as well as a preparation method and application thereof, and relates to the technical field of livestock breeding. The traditional Chinese medicine composition for resisting chicken coccidiosis is prepared from the following raw materials in parts by mass: 20 to 60 parts of pericarpium citri reticulatae, 10 to 30 parts of fructus mume, 10 to 30 parts of herba agrimoniae and 5 to 20 parts of fructus crataegi. According to the invention, chicks are taken as experimental subjects, a chick coccidiosis model is established, and the effect of the traditional Chinese medicine composition on the chick coccidiosis is researched from the aspects of general conditions of the chicks, bloody stool conditions, coccidian oocyst discharge conditions, cecum tissue lesion conditions, pathological detection, serum biochemistry, oxidation resistance detection and the like. The traditional Chinese medicine composition has the effects of resisting insects and diminishing inflammation, stopping dysentery and diarrhea, stopping bleeding and resisting diseases and the like, all the medicinal materials are common traditional medicinal materials, the needed raw materials are low in cost, the preparation process is simple, no toxic or side effect is caused to chickens, hormones and antibiotics are not contained, and a new choice is provided for replacing chemicals for preventing and treating coccidiosis.

The invention discloses application of ursolic acid or ursolic acid derivatives in preparation of chicken coccidiosis-resistant feed or chicken coccidiosis-resistant drugs, and relates to the technical field of biological medicines. The chicken coccidiosis protozoon is chicken eimeria tenella, the ursolic acid derivative is oleanolic acid, and the ursolic acid derivative and ursolic acid are isomers. The chicken coccidiosis-resistant feed or the chicken coccidiosis-resistant drug has at least one of the following functions: reducing the cecum lesion value and the number of oocysts, and inhibiting the depth increase of crypts induced by chicken coccidiosis; weight loss caused by chicken coccidiosis infection is relieved; the expression of inflammatory factors caused by chicken coccidiosis infection is reduced, and the inflammatory factors comprise IL-6, IL-8, TNF-alpha and IFN-gamma; the expression of tight junction protein after chicken coccidiosis infection is promoted, and the tight junction protein comprises ZO-1, Claudin-1 and Occludin. The traditional Chinese medicine composition has the advantages of low toxicity, low residue, good anti-chicken coccidiosis effect, simplicity in preparation, suitability for batch production and the like.

The present disclosure relates to a composition comprising quinic acid for preventing, alleviating or treating coccidiosis, and an antiprotozoal composition against Eimeria sporozoites.

The present disclosure provides a composition comprising an effective amount of a Trifolium pratense (TP) extract (TPE) or an active ingredient(s) contained therein (TP API), or a combination of TP and TPE or TP and TP API. The present disclosure further provides uses of the composition.

The present application relates to the use of a composition for preventing, alleviating or treating coccidiosis and against Eimeria protozoa. The composition comprises an active ingredient for preventing, relieving or treating coccidiosis, and the active ingredient consists of coumaric acid or a pharmaceutically acceptable salt thereof. According to one embodiment, the composition comprising cumaric acid and / or a salt thereof has an excellent effect of inhibiting cell infiltration of protozoa capable of inducing coccidiosis and / or inhibiting proliferation of protozoa in cells, has an excellent effect of preventing, alleviating and treating coccidiosis in vivo, and significantly reduces the oocyst excretion rate in faeces, and thus has an excellent effect of preventing, alleviating and treating coccidiosis in vivo. Therefore, secondary coccidiosis infection can be reduced.

This invention belongs to the field of veterinary drug preparation and discloses a traditional Chinese medicine composition and its application in the preparation of drugs for preventing Eimeria tenella and improving the growth performance of chicks. The traditional Chinese medicine composition comprises the following components in parts by weight: 8-12 parts of Costus root, 8-12 parts of white hyacinth bean, 4-8 parts of immature bitter orange, 4-8 parts of peony root, 8-12 parts of milkweed root, 4-8 parts of cinnamon twig, 12-18 parts of astragalus root, 4-8 parts of ginger, and 4-8 parts of licorice root. This traditional Chinese medicine composition has the effects of warming yang and dispelling cold, strengthening the spleen and promoting diuresis, and regulating qi and relieving stagnation. It has a good preventive effect on Eimeria tenella and can improve the growth performance of chicks, without toxic side effects.

This invention relates to the field of veterinary medicine technology and provides a traditional Chinese medicine composition for treating coccidiosis in chickens, along with its preparation method. The composition is prepared from a combination of raw materials including *Gnaphalium affine*, *Hedyotis diffusa*, *Dendrobium nobile*, *Hemiberlesia argyi*, and *Thalictrum sylvestris*. This pure traditional Chinese medicine preparation exhibits no drug resistance, no drug residues, no toxic side effects, and no palatability issues. It also possesses advantages such as significant efficacy, rational formulation, simple preparation, low cost, and environmental friendliness. The traditional Chinese medicine composition of this invention has the effects of stopping diarrhea and killing parasites, clearing heat and drying dampness, and tonifying the middle and replenishing qi. It has a significant effect against coccidiosis in chickens, effectively preventing abnormal feces, intestinal bleeding, and intestinal ulcers caused by coccidiosis, and rapidly restoring the production performance of chicken flocks, thus improving breeding profits.

The invention discloses a compound traditional Chinese medicine and application thereof in preparing a medicine for resisting eimeria tenella or treating coccidiosis, and relates to the technical field of livestock breeding. The compound traditional Chinese medicine comprises the following raw materials in parts by mass: 5-20 parts of hesperidin and 1-10 parts of citric acid. According to the invention, chicks are taken as experimental subjects, a chick coccidiosis model is established, and the effect of the compound traditional Chinese medicine on the chick coccidiosis is researched from the aspects of general conditions of the chicks, bloody stool conditions, coccidiocyst discharge conditions, cecum tissue lesion conditions, pathological detection, serum biochemistry, oxidation resistance detection and the like. The compound traditional Chinese medicine achieves a good anti-coccidiosis drug level, the required raw materials are low in cost, convenient to use and free of hormones and antibiotics, no toxic or side effect is caused to chickens, drug resistance cannot be caused, a new choice is provided for replacing chemical drugs for preventing and treating coccidiosis, and addition of anti-coccidiosis drugs in chicken feed is expected to be reduced or replaced.

The present application relates to a kind of recombinant plant lactobacillus expressing anchor Eimeria tenella RON2 antigen and application.The recombinant plant lactobacillus provided in the present application contains RON2-dendritic cell targeting peptide (DCpep) fusion protein transcription gene, which is composed of RON2 gene fragment and 3 DCpep gene fragments in series.The fusion protein has good immunogenicity, can be expressed on the surface of plant lactobacillus by pgsA' vector anchoring, and can be used to prepare oral vaccine.Compared with commercially available vaccine, the weight gain rate and anticoccidial index of the recombinant plant lactobacillus immune group of chicken are significantly increased, and the oocyst excretion and cecal lesion are significantly reduced.The above results confirm that the recombinant plant lactobacillus constructed in the present application, which targets dendritic cells and anchors Eimeria tenella RON2 antigen on the surface for oral administration, has good immunoprotective effect, and provides a new direction for the prevention and control of chicken Eimeria tenella disease in poultry breeding process.

The present invention relates to a composition for use in the treatment and / or prevention of coccidiosis-induced symptoms in poultry, comprising guanidinoacetic acid, a salt of guanidinoacetic acid, or a mixture thereof.

The invention discloses a toltrazuril nano suspension and a preparation method thereof, and belongs to the technical field of veterinary drug preparations. The suspension contains toltrazuril, an iron compound, a bacteriostatic agent, a suspending aid, a stabilizer and the balance of water. According to the invention, an ultrahigh-pressure nano homogenizer technology is adopted, the medicine is prepared into a nano-scale particle size, and the medicine is uniformly dispersed in the preparation, so that the medicine has good stability and dispersibility. The preparation not only can be used for effectively preventing and treating animal coccidiosis, but also can improve animal anemia, and has a wide clinical application prospect.

The present application relates to an anticoccidial composition comprising Garcinia mangostana and uses thereof. According to embodiments, the composition comprising Garcinia mangostana has an excellent effect of directly killing protozoa that can induce coccidiosis, has an effect of inhibiting penetration of cells by the protozoa, and / or has an effect of inhibiting proliferation of the protozoa in cells, and has an excellent effect on prevention, alleviation, and treatment of coccidiosis in vivo.

The present application relates to an anticoccidial composition comprising ginkgo leaves and use thereof. The composition comprising ginkgo leaves, according to an embodiment, has excellent effects of directly killing sporozoites that can induce coccidiosis, inhibiting the penetration of the sporozoites into cells, and / or inhibiting the proliferation of the sporozoites in cells, and has excellent effects of preventing, ameliorating and treating coccidiosis in vivo.

The present application relates to an anticoccidial composition comprising coumaric acid and use thereof. A composition comprising coumaric acid and / or a salt thereof, according to an embodiment, has excellent effects of inhibiting the cell penetration of protozoa that can induce coccidiosis and / or inhibiting the proliferation of the protozoa in cells, has excellent effects of preventing, ameliorating and treating coccidiosis in vivo, and remarkably reduces oocyst excretion in feces, thus being able to reduce secondary coccidiosis infection.

The application relates to preparation and application of a nano-subunit vaccine for preventing chicken coccidiosis. The nano-subunit vaccine PLGA-rEmTregIM-1 is prepared by coating a giant Eimeria maxima Treg inducing molecule EmTregIM-1 recombinant protein (rEmTregIM-1) with PLGA nanoparticles. The immunoprotective effects of the subunit vaccine rEmTregIM-1 and the nano-subunit vaccine PLGA-rEmTregIM-1 are evaluated through animal immunoprotection tests, and the results show that both the vaccines can produce partial immunoprotections for the giant Eimeria maxima infection. After the recombinant protein subunit vaccine rEmTregIM-1 is coated with the PLGA nanoparticles, the nano-subunit vaccine PLGA-rEmTregIM-1 has an improved immunoprotection effect on animals compared with the subunit vaccine rEmTregIM-1.

The present application relates to an anticoccidial composition comprising a stilbene-based compound, and a use thereof. A composition comprising a compound or a salt thereof, according to one embodiment, has excellent effects of direct killing of protozoa that can induce coccidiosis, inhibiting the cell penetration of the protozoa and / or inhibiting the intracellular proliferation of the protozoa, and preventing, alleviating, and treating in vivo coccidiosis.

The application discloses a plant source composition which is composed of eucalyptus leaf essential oil, eugenol essential oil and apigenin, and discloses a preparation method of the composition and application of the composition in resisting chicken coccidiosis, and belongs to the field of disease prevention and treatment of poultry and livestock and feed additive. The composition can resist Eimeria tenella, and has a promoting effect on the growth performance of chickens, is a new type of feed additive with small toxic and side effects and good insecticidal effect, has low production cost and good stability, and has great application prospect in the aspect of coccidiosis resistance of poultry.

The present invention relates to a composition comprising a C. suis hapless protein 2 (HAP2), a C. suis oocyst wall protein 1 (OWP1) and a C. suis tyrosine-rich protein (TyRP), which can be administered to a pregnant sow ante partum, to protect its piglets against suckling piglet coccidiosis. The invention also relates to the use of said composition, the method of preparing said composition and a kit of parts comprising the composition.