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Method for testing quality of medicine for treating alzheimer's disease

A quality detection method, Alzheimer's disease technology, applied in the field of medicine, can solve the problem that there is no specific and effective therapy

Inactive Publication Date: 2014-08-06
SICHUAN SHUYUAN BOYE MEDICINE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there is no specific effective therapy for AD so far that can stop and reverse the progression of the disease.

Method used

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  • Method for testing quality of medicine for treating alzheimer's disease
  • Method for testing quality of medicine for treating alzheimer's disease
  • Method for testing quality of medicine for treating alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 medicament oral liquid of the present invention

[0029] Weigh raw materials: Yizhi 50g, Cuscuta (boiled in wine) 100g, Polygala 100g, Rehmannia glutinosa 100g, Schisandra 30g, Chuanxiong 100g, Gardenia 100g; make 1000ml

[0030] For the above seven flavors, take Yizhi and add 30 times the amount of water to soak for 1 hour, then add Ligusticum chuanxiong, extract the volatile oil by steam distillation for 4 hours, collect the volatile oil and extract separately, and set aside; combine the dregs with other medicinal materials, add 10 times Measure water, extract twice, each extraction time is 2h, combine all extracts, concentrate under reduced pressure (temperature not exceeding 80°C, vacuum degree -0.04-0.08MPa) to a specific gravity of 1.15-1.20, add ethanol to make it contain The alcohol content is 85%, let stand for 24 hours, filter, take the filtrate, concentrate under reduced pressure (the temperature does not exceed 80°C, the vacuu...

Embodiment 2

[0033] The preparation of embodiment 2 medicines of the present invention

[0034] Weigh raw materials: Yizhi 25g, Cuscuta (boiled in wine) 50g, Polygala 50g, Rehmannia glutinosa 50g, Schisandra chinensis 15g, Chuanxiong 50g, Gardenia 50g, add water to decoct, concentrate, add flavoring agents, etc. to prepare oral liquid.

Embodiment 3

[0035] Embodiment 3 preparation of medicine of the present invention

[0036] Weigh raw materials: Yizhi 75g, Cuscuta 150g, Polygala 150g, Rehmannia glutinosa 150g, Schisandra 45g, Chuanxiong 150g, Gardenia 150g, powdered directly, compressed into tablets to obtain tablets.

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Abstract

The invention provides a method for testing quality of medicine for treating alzheimer's disease. The medicine is prepared from the following raw material medicines in parts by weight: 25-75 parts of alpinia oxyphylla miq, 50-150 parts of dodder, 50-150 parts of milkwort, 50-150 parts of dried rehmannia root, 15-45 parts of schisandra, 50-150 parts of ligusticum wallichii, and 50-150 parts of cape jasmine fruit. The quality control method of the medicine comprises a film discrimination method and a quantitative detection method. The detection method provided by the invention is not limited by evaporability and thermal stability of a sample, and is wide in application range; the mobile phases are various, and can be optimized to achieve a high separating efficiency; generally, analysis is carried out at the room temperature; high column temperature is not required; a high-performance liquid chromatography is an accurate fast quantitative detection method for gardenoside, and can make a quality standard for gardenoside.

Description

technical field [0001] The invention relates to a quality detection method of medicine for treating Alzheimer's disease, which belongs to the field of medicine. Background technique [0002] Since the 1990s, published dementia clinicopathological studies have confirmed that 5-10% of the elderly over the age of 65 suffer from some kind of cognitive decline or dementia, of which more than 50% of the cases are caused by Alzheimer's disease (Alzheimer's disease, AD), and more women than men. Alzheimer's disease, also known as Alzheimer's disease, is a degenerative disease of the central nervous system that occurs in old age and is characterized by progressive dementia. It was first described in 1907 by German physician Alois Alzheimer. Its main clinical manifestations are progressive cognitive dysfunction and memory decline, personality and behavior changes, confusion, loss of thinking and judgment, loss of self-care ability, and eventually death. This devastating degenerativ...

Claims

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Application Information

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IPC IPC(8): G01N30/90
Inventor 王智英强六平
Owner SICHUAN SHUYUAN BOYE MEDICINE SCI & TECH
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