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Preparation method of traditional Chinese medicine extract tablet

A technology of extracts and traditional Chinese medicines, applied in the field of Chinese medicine extract tablets and their preparation, to achieve the effects of shortened disintegration time, uniform appearance and appropriate size

Inactive Publication Date: 2014-08-13
NANCHANG JISHUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem solved by the present invention is that the Chinese medicine extract tablet cannot have a good disintegration effect while having a moderate volume.

Method used

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  • Preparation method of traditional Chinese medicine extract tablet

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preparation example Construction

[0024] The preparation method of the present invention includes: extracting traditional Chinese medicine, drying the extract into extract, selecting excipients, mixing extract and excipients, spray granulation, and compressing tablets. Among them, the temperature of the material after the step of mixing the extract and the excipient is 60-80°C; in the spray granulation step, the atomization pressure I is 0.05-0.1MPa, the atomization pressure II is 0.05-1Mpa, and the spray speed It is 10-20r / min.

[0025] The reason for choosing the above material temperature: when the material temperature is lower than 60℃, the extract is sprayed with excipients to form particles and the drying is not timely enough to cause material adhesion and wall hanging, and the atomization pressure and spray speed cannot be adjusted greatly. , Which directly affects the granulation of the particles, and the particle diameters obtained are smaller. When the temperature of the material is about 60-80℃, the m...

Embodiment 1

[0036] Example 1 Hedan preparation extract tablet

[0037] (1) Extract Chinese medicine:

[0038] Hedan extract was prepared and extracted according to the method of loading Dan tablets in the pharmacopoeia. The Chinese medicine prescription is a prescription for Hedan tablets, including lotus leaf, hawthorn, salvia, senna, and psoralen.

[0039] (2) Dry extract into extract:

[0040] The extract is concentrated to an extract with a relative density of 1.22-1.26 (measured at 80°C), and the water content of the extract is 42.3%.

[0041] (3) Select excipients:

[0042] The dextrin, starch, and disintegrant are taken to form excipients in a mass ratio of 2.5:5:1.5, and the disintegrant is preferably sodium carboxymethyl starch.

[0043] (4) Mixed extract and excipients:

[0044] Use 75% ethanol to disinfect and dry the inner wall of the equipment mainframe. After the equipment is dry, add 0.9 kg of excipients into the multifunctional granulator, push into the host, and pour 2.25 kg of extr...

Embodiment 2

[0049] Example 2 Preparation of Jiangzhiling Tablets

[0050] (1) Extract Chinese medicine:

[0051] Take 2.22 kg of Polygonum multiflorum, 2.22 kg of wolfberry, 2.96 kg of Polygonatum, 1.48 kg of hawthorn, and 0.44 kg of cassia seed, and extract the extract according to the preparation method of Jiangzhiling tablets recorded in the 2010 Chinese Pharmacopoeia.

[0052] (2) Dry extract into extract:

[0053] The extract is concentrated to the extract for later use, and the water content of the extract is 45%.

[0054] (3) Select excipients:

[0055] Dextrin, starch, and disintegrant are taken to form excipients in a mass ratio of 2:10:1, wherein the disintegrant is preferably low-substituted hydroxypropyl cellulose.

[0056] (4) Mixed extract and excipients:

[0057] Use 75% ethanol to disinfect and dry the inner wall of the equipment mainframe. After the equipment is dry, add 1.77kg of excipients into the multifunctional granulator, push it into the host, and pour 2.66kg of extract into t...

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Abstract

A traditional Chinese medicine extract tablet comprises an extract of traditional Chinese medicine extract and an excipient; wherein the weight ratio of the extract to the excipient is (1.5-4):1, and the excipient is composed of dextrin, starch, and a disintegrating agent. The preparation method of the traditional Chinese medicine extract table comprises the following steps: extracting traditional Chinese herbals, drying the extract to obtain a dried extract, selecting an excipient comprising dextrin, starch, and a disintegrating agent, mixing the extract and the excipient according to a weight ratio of (1.5-4):1, carrying out spray-granulating, and finally pressing the granules into tablets, wherein the water in the extract accounts for 30 to 60% of the total weight of the extract, the material temperature is 60 to 80 DEG C after the extract and excipient mixing process, in the spray-granulating process, the atomizing pressure I is 0.05 to 0.1 MPa, the atomizing pressure II is 0.05 to 1 MPa, and the spraying speed is 10 to 20 r / min. The traditional Chinese medicine extract tablet has the advantages of proper size, uniform appearance, and prominently-reduced disintegration time.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to a traditional Chinese medicine extract tablet and a preparation method thereof. Background technique [0002] Chinese medicinal extract tablets usually refer to Chinese medicinal material extracts or Chinese medicinal material extracts plus fine Chinese medicinal material powder and suitable excipients, mixed and compressed or made into tablet form by other suitable methods, with accurate dosage, stable quality and taking Convenience, easy identification, low cost and other advantages. Due to the complex components in traditional Chinese medicine extracts, there are components such as protein, polysaccharides, starch, tannins, etc. In addition, a large number of polar groups such as hydroxyl and amino groups in traditional Chinese medicine extracts are easily combined with polar hydroxyl groups in water molecules. , Usually high hygroscopicity and viscosity, leading to cracks...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/40A61K47/36
Inventor 何凯南曾英姿周万辉安少凯张丹赵磊陈武
Owner NANCHANG JISHUN PHARMA CO LTD
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