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Application of myricetrin for preventing and treating osteoporosis

A technology for osteoporosis and bone marrow mesenchymal, which is used in medical preparations containing active ingredients, bone diseases, organic active ingredients, etc. It can solve problems such as damage to cell structure and function, improve oxidative stress state, inhibit Expression and improvement of cancellous bone microstructure

Inactive Publication Date: 2014-08-20
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, high concentrations of ROS can lead to oxidation reactions of nucleic acids, proteins, and lipids, damage the structure and function of cells, and cause diseases

Method used

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  • Application of myricetrin for preventing and treating osteoporosis
  • Application of myricetrin for preventing and treating osteoporosis
  • Application of myricetrin for preventing and treating osteoporosis

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Embodiment Construction

[0034] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments, which are explanations rather than limitations of the present invention.

[0035] hBMSC is a human bone marrow mesenchymal stem cell with multidirectional differentiation potential, such as differentiation into osteoblasts, adipocytes, fibroblasts, etc. It is a more commonly used cell model for studying the growth and differentiation of bone marrow mesenchymal stem cells. Hydrogen peroxide (H 2 o 2 ) treatment is also a commonly used in vitro oxidative stress model. In order to observe the effect of myricetin on the apoptosis and differentiation of human bone marrow mesenchymal stem cells, and its anti-oxidative damage, hBMSC was selected as the cell model. H 2 o 2 Treated as an in vitro model of oxidative stress. As an animal model, the ovariectomized (castrated) mouse model is a commonly used model for simulating postmenopausal osteoporosis in wome...

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Abstract

The invention discloses an application of myricetrin for preventing and treating osteoporosis. Myricetrin is free from toxic effect on human mesenchymal stem cells, does not affect cell proliferation, has a protective effect on apoptosis of the human mesenchymal stem cells caused by H2O2, improves the oxidative stress state induced by H2O2 in the differentiation process, has a protective effect on ossifying differential inhibition of human bone mesenchymal stem cells caused by H2O2, has an inhibiting effect on enhancement of adipogenic differentiation of human bone mesenchymal stem cells caused by H2O2, and can inhibit expression of bone absorption factors so as to improve apoptosis and differential inhibition of the human mesenchymal stem cells and indirectly inhibit osteoclast activation to protect osteoporosis. In an osteoporotic model of a castrated mouse, the myricetrin can improve the oxidative stress state in serum and improve the bone micro-structures of the cancellous bone at the distal femur and the fourth lumbar vertebra, so that the myricetrin can improve the bone micro-structure by inhibiting oxidative stress and exerting the effect of preventing and treating osteoporosis.

Description

technical field [0001] The invention belongs to the technical field of prevention and treatment of osteoporosis, and relates to the application of myricetin in the prevention and treatment of osteoporosis. Background technique [0002] Osteoporosis (OP) is a systemic, degenerative, metabolic skeletal disease characterized by loss of bone mass, deterioration of bone microarchitecture, and decline in biomechanical properties caused by various etiologies, resulting in increased bone fragility and prone to Fractures seriously threaten the physical and mental health of middle-aged and elderly people. [0003] Oxidative stress is a state in which highly active substances such as ROS (Reactive oxygen species) are produced excessively in the body, which exceeds the body's ability to remove them, resulting in an imbalance between oxidation and anti-oxidation. ROS in the physiological range play an important role in regulating normal functions of the human body, such as cell apoptosi...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P19/10
Inventor 刘建黄强高博杨柳罗卓荆
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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