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Application of recombinant ganoderma lucidum immunoregulatory protein in preparation of medicine for treating androgenetic alopecia

An immunomodulatory protein and androgenic technology, applied in drug combinations, peptide/protein components, pharmaceutical formulations, etc., can solve the problems of no AGA drugs and high recurrence of AGA, and achieve good therapeutic effect, high safety, The effect of improving the symptoms of androgenetic alopecia

Inactive Publication Date: 2014-08-27
张喜田 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The various existing treatment methods for AGA have their limitations. In addition, AGA itself is a stubborn and recurrent disease. So far, no drug that can fundamentally treat AGA has been found.

Method used

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  • Application of recombinant ganoderma lucidum immunoregulatory protein in preparation of medicine for treating androgenetic alopecia
  • Application of recombinant ganoderma lucidum immunoregulatory protein in preparation of medicine for treating androgenetic alopecia
  • Application of recombinant ganoderma lucidum immunoregulatory protein in preparation of medicine for treating androgenetic alopecia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 rLZ-8 can improve the hair loss in mice induced by testosterone propionate.

[0021] 1 Experimental materials

[0022] rLZ-8 (provided by the Institute of Genetic Engineering Drugs of Jilin University), testosterone propionate injection (Shanghai General Pharmaceutical Co., Ltd.).

[0023] 2 Instruments and equipment

[0024] Grate, tweezers, ziplock bag, Canon camera.

[0025] 3 Experimental animals

[0026] Healthy and flexible ICR mice, half male and half female, weighing 20±2g, SPF grade. Purchased from the Basic Animal Center of Jilin University, animal license number: SCXK Beijing 2009-0004. Raised under SPF grade conditions of Jilin University. During the experiment, the room temperature was controlled at 20°C ± 2°C, the lighting was alternated for 12 hours, and the mice were given free access to water and food.

[0027] Animals were inspected for hair before administration, and 60 qualified mice were selected and randomly divided into 6 groups, 1...

Embodiment 2

[0038] Example 2 rLZ-8 can improve the secretion balance of sex hormones in mice and its influence on major organ indexes

[0039] 1 Experimental materials

[0040] rLZ-8 (provided by the Institute of Genetic Engineering Drugs of Jilin University), testosterone propionate injection (Shanghai General Pharmaceutical Co., Ltd.).

[0041] 2 Instruments and equipment

[0042] Low temperature centrifuge (eppendorf centrifuge 5810R), digital display constant temperature circulating water tank (Guohua HH-42 type), 752 type ultraviolet grating spectrophotometer (Shandong Gaomi Analytical Instrument Factory).

[0043] 3 Experimental animals

[0044] Healthy and flexible ICR mice, half male and half female, weighing 20±2g, SPF grade. Purchased from the Basic Animal Center of Jilin University, animal license number: SCXK Beijing 2009-0004. Raised under SPF grade conditions of Jilin University. During the experiment, the room temperature was controlled at 20°C ± 2°C, the lighting was ...

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Abstract

The invention discloses application of recombinant ganoderma lucidum immunoregulatory protein (rLZ-8) in androgenetic alopecia. In-vivo animal model experiments show that the recombinant ganoderma lucidum immunoregulatory protein is capable of improving depilation of an androgenetic alopecia anomal model and can be used for preventing and treating androgenetic alopecia. The recombinant ganoderma lucidum immunoregulatory protein disclosed by the invention is a high-purity protein substance prepared through a recombination technology and a yeast cell eukaryotic expression system.

Description

technical field [0001] The present invention relates to a new application of recombinant Ganoderma lucidum immunoregulatory protein expressed by Pichia pastoris in the treatment of androgenetic alopecia, in particular to the use of recombinant Ganoderma lucidum immunomodulatory protein in preventing, alleviating and / or treating androgenetic alopecia. The use in hormone-induced alopecia belongs to the field of biomedical engineering (biomedical field). Background technique [0002] Androgenetic Alopecia (AGA), also known as Seborrheic Alopecia (SA), Male Pattern Alopecia (MPA), is a common, frequently-occurring, and refractory disease in dermatology. One, the course of the disease is long and stubborn. The clinical symptoms often manifest as greasy hair, dandruff, obvious itching, progressive hair loss in the frontotemporal area and the top, and then form a "high forehead". Temporal hair is basically normal. Male pattern hair loss is a worldwide dermatological problem. Fro...

Claims

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Application Information

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IPC IPC(8): A61K38/16A61P17/14A61P17/08
CPCA61K38/16
Inventor 孙非梁重阳张喜田
Owner 张喜田
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