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Use of botrychium ternatum extract in preparation of drugs for treatment of pulmonary heart disease

A technology of extracts of young spring flowers, applied in the field of small spring flower extracts, to achieve the effect of enriching the research base

Inactive Publication Date: 2014-10-15
黄萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prevention and treatment of cor pulmonale has always been a major problem in medicine. At present, there are no mature therapeutic drugs and measures that can effectively reduce pulmonary hypertension, relieve and improve right ventricular remodeling, and have no obvious adverse reactions.

Method used

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  • Use of botrychium ternatum extract in preparation of drugs for treatment of pulmonary heart disease
  • Use of botrychium ternatum extract in preparation of drugs for treatment of pulmonary heart disease
  • Use of botrychium ternatum extract in preparation of drugs for treatment of pulmonary heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: Preparation of Xiaochun flower extract

[0019] The whole herb of the wild collected spring flowers is dried and pulverized. Weigh 80.0 g of small spring flower powder, heat and reflux extraction with 10 times the volume of 70% ethanol solution for 3 times, each time for 2 hours, filter, combine the filtrates, and concentrate under reduced pressure until there is no alcohol smell. The Artemisia argyi extract prepared in the above examples can be further prepared into pharmaceutical preparations of the Artemisia argyi extract, such as tablets, capsules, granules and other pharmaceutically acceptable pharmaceutical dosage forms.

Embodiment 2

[0020] Embodiment 2: Preparation of the effective part extract of Xiaochun flower

[0021] Take the whole herb of Xiaochunhua, dry it, crush it, and set it aside; add 8 times the amount of 70% alcohol solution for reflux extraction, heat and reflux extraction twice, each time for 2 hours, and combine the extracts. Add the extract to the adsorption resin column until light yellow with water, wash with 10% to 90% alcohol, recover the alcohol, and dry to obtain a brown powder containing the total flavonoids

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Abstract

The invention relates to the use of botrychium ternatum extract in drugs for treatment of pulmonary heart disease and a preparation method of the botrychium ternatum extract. The invention discloses the use of the botrychium ternatum extract in preparation of the drugs for treatment of pulmonary heart disease. The pulmonary heart disease has the characteristics of high prevalence, high morbidity, high mortality and high expense, investigations reveal that prevalence rate of northern rural residential population in China is 0.44 %, so that development of a traditional Chinese medicine having the advantages of therapeutic confirmatory, reasonable cost and adequate supply for treatment of the pulmonary heart disease is important in meaning. At the same time, the traditional Chinese medicine artemsia argyi is further developed and researched, and final market promotion of the artemsia argyi is an important path for the modernization of traditional Chinese medicines.

Description

technical field [0001] The present invention relates to the use of the extract of the young spring flower, in particular to the use of the small spring flower extract in the preparation of medicines for treating cor pulmonale. Background technique [0002] Cor pulmonale (pulmonary heart disease) is a change in the structure and (or) function of the lung tissue caused by chronic disease of the lung tissue, pulmonary vessels, or thorax, resulting in increased pulmonary vascular resistance, increased pulmonary artery pressure, and dilated or (hypertrophic) right ventricle ), with or without right heart failure. The main pathological changes of cor pulmonale include pulmonary arterial hypertension (PAH) and heart disease, among which PAH is the central link and prerequisite in the pathogenesis of cor pulmonale, and the final destination and concentrated manifestation of cor pulmonale in heart disease. The main treatment measures include improvement of respiratory function, corr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61P11/00A61P9/12A61P9/00
Inventor 黄萍叶佐武杨秀丽戴纯辉应茵羊波袁雍
Owner 黄萍
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