Method for preparing electrochemical sensor based on synthetic zinc oxide nano-rod

A zinc oxide nanorod, electrochemical technology, applied in the direction of electrochemical variables of materials, etc., can solve the problems of complex sample preparation procedures, long analysis time, similar hydrazine structure, etc., and achieves good repeatability, simple operation, and low detection limit. Effect

Inactive Publication Date: 2014-10-15
WUXI BAILING SENSING TECH
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Problems solved by technology

[0004] Levodopa and methyldopa hydrazine are similar in structure and difficult to separate, so there are few methods for simultaneous detection of both. At present, the detection of levodopa and methyldopa hydrazine in biological samples and drugs includes: spectrophotometry , high performance liquid chromatography, and chemiluminescence, etc., but each method encounters limitations from cost, selectivity, use of organic solvents, complex sample preparation procedures, and long analysis times

Method used

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Embodiment Construction

[0012] In order to deepen the understanding of the present invention, the present invention will be further described below in conjunction with implementation.

[0013] An electrochemical sensor preparation method for the detection of levodopa in the presence of methyldopa hydrazine based on the synthesis of zinc oxide nanorods, the steps are as follows:

[0014] (1) Synthesis of ZnO nanorods: first prepare 300mL of 0.015mol / L Zn(NO 3 ) 2 ·6H 2 O solution, and hexamethylenetetramine (HMT) were put into a pressure bottle at the same time, the fiber was immersed in the pressure bottle solution, heated at 60°C for 12h, and the precipitate was centrifuged at 30000rpm.

[0015] (2) Synthesis of 5-(4'-amino-3'-hydroxyl-diphenyl-4-alcohol)-acrylic acid: 1.09g (10mmol) 2-aminophenol, 2.27g (10mmol) 4-bromostyrene Acid and 5g tetrakis (triphenylphosphine) palladium (Pd (PPh 3 ) 4 ) into a 200mL conical flask, then add 20mL dimethylacetamide (DMA), heat to 80°C for 24h, cool for 20...

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Abstract

The invention relates to a method for preparing an electrochemical sensor based on both a synthetic zinc oxide nano-rod and a novel 5-(4'-amino-3'-hydroxyl-diphenyl-4-alcohol)-acrylic acid modified carbon paste electrode. The electrochemical sensor is used for detecting levodopa with existence of carbidopa, is simple to operate, high in response speed, good in repeatability and low in price and has a lower detection limit; during detection, the time-consuming extraction step is not needed, influence from pH is avoided, reaction with oxygen does not happen and innocuity is ensured; therefore, the electrochemical sensor is simple, accurate, precise, low-price and quick in detection, and has a relatively good application prospect in clinical practice that carbidopa and levodopa are detected at the same time.

Description

technical field [0001] The invention relates to a method for preparing an electrochemical sensor, in particular to a method for preparing an electrochemical sensor based on synthetic zinc oxide nanorods for detecting levodopa in the presence of methyldopa hydrazine. Background technique [0002] The main cause of Parkinson's disease patients is the severe degeneration of dopamine neurons contained in the brain, and dopamine cannot be used directly for treatment because it cannot cross the blood-brain barrier. Levodopa, the precursor of dopamine, can cross the blood-brain barrier and be converted into dopamine by dopamine decarboxylase in the brain. Therefore, levodopa is widely used in the clinical treatment of Parkinson's disease. [0003] If the content of levodopa is too high, it will be metabolized into excessive dopamine, which will cause side effects, such as nausea, vomiting, postural hypotension, etc., and more seriously, it may cause mental disorders. Levodopa is u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30
Inventor 孙京华潘正海
Owner WUXI BAILING SENSING TECH
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