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Pharmaceutical composition for elimination of cancer stem cells

A pharmaceutical composition, cancer stem cell technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2014-10-22
黄奇英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, once EGFR-TKI resistance and transfer occur, there is no effective means to prevent it

Method used

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  • Pharmaceutical composition for elimination of cancer stem cells
  • Pharmaceutical composition for elimination of cancer stem cells
  • Pharmaceutical composition for elimination of cancer stem cells

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[0049] 1. Materials and methods

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Abstract

The preset invention relates to use of antipsychotic phenothiazine derivative for eliminating cancer stem cells (CSCs) and / or preventing a cancer. The invention also provides a pharmaceutical composition for treating a cancer, and / or preventing or delaying cancer recurrence comprising trifluoperazine and an anti-cancer drug, such as gefitinib or cisplatin.

Description

technical field [0001] The invention relates to a pharmaceutical composition for eliminating cancer stem cells. Background technique [0002] Recently, the cancer stem cell (CSC) hypothesis has attracted much attention. CSCs possess stem cell properties, including self-renewal, stress / drug resistance, and enhanced mobility, which lead to tumor recurrence, metastasis, and chemotherapy resistance. Putative CSCs were first identified as CD133 + / Oct4 + / Nanog + cells (Eramo A et al. Cell Death Differ2008; 15:504-514), and isolated from established non-small cell lung cancer (NSCLC) cell lines (Pirozzi G et al. PloS one2011; 6:e21548; and Leung EL et al. PloS one 2010;5:e14062). Lung CSCs may have the same functional properties as lung precursor cells, including the ability to actively exclude the Hoechst stain (Hoechst) 33342, which identified these cells as side population cells in flow cytometry ( Storms RW et al. Blood2000; 96:2125-2133), and expressed high aldehyde de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5415A61P35/00A61P35/04A61K33/243
CPCA61K31/5415A61N5/10A61K31/5377A61K33/24A61K31/4706A61K45/06A61P11/00A61P35/00A61P35/04A61P43/00A61K33/243A61K2300/00
Inventor 黄奇英
Owner 黄奇英
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