11 results about "Thiazide derivatives" patented technology

The invention provides a diaphragm and a secondary battery, and belongs to the technical field of secondary batteries, and the diaphragm comprises a base membrane and a coating. Wherein the coating is arranged on one surface, facing the positive pole piece, of the base film, and the coating comprises an electroactive material and a binder; the electroactive material comprises at least one of a quinone derivative, a phenazine derivative, an imide derivative and a phenothiazine derivative. The electroactive material in the diaphragm coating can be dissolved in the electrolyte after the environment temperature reaches the thermal safety critical temperature, and reacts with the positive and negative active materials, so that the charge state of the battery is quickly reduced, and the thermal runaway of the battery is inhibited or even avoided.

The invention belongs to the technical field of pesticides and plant disease control, and provides an antifungal phenothiazine derivative which can inhibit various fungal diseases on rice and tobacco. The derivative can also be compounded with triazole or fluazinam to prevent and treat fungal diseases of rice and tobacco, and has a good development prospect.

The present invention relates to a polysubstituted imidazolo[4,5-c][1,2]thiazine derivative and a use of an agent comprising same as an active agent, which is useful for infectious diseases associated with vascular inflammation caused by HMGB1 protein activity. It has been found that the polysubstituted imidazolo[4,5-c][1,2]thiazine derivative of the present invention increases the sepsis survival rate as a result of searching for antiseptic effects through CLP-induced sepsis animal experiments. Accordingly, the agent comprising the polysubstituted imidazolo[4,5-c][1,2]thiazine derivative or a pharmaceutically acceptable salt thereof as an active agent may be advantageously used as a therapeutic agent for infectious diseases and vascular inflammatory diseases including sepsis caused by HMGB1 protein activity.

The invention belongs to the technical field of medicines, and particularly relates to an alpha-lipoic acid phenothiazine derivative as well as a preparation method and application thereof. The structural formula of the alpha-lipoic acid phenothiazine derivative is as shown in formula 1. The invention provides an alpha-lipoic acid phenothiazine derivative, and research finds that the alpha-lipoic acid phenothiazine derivative shows good anti-inflammatory activity which is slightly superior to that of alpha-lipoic acid. Moreover, the effect of the pharmaceutical composition is better than that of a positive drug edaravone clinically used in cerebral arterial thrombosis at present, and the pharmaceutical composition can be further developed into a treatment drug applied to ferroptosis related diseases. .

The present invention provides a phenothiazine derivative, a synthesis method thereof, and its application in food freshness detection. The present invention designs and synthesizes a fluorescent molecule based on a phenothiazine derivative with protonation / deprotonation behavior. Using the protonated phenothiazine derivative as the detection target, and 1,4-butanediamine and 1,5-pentanediamine produced during food spoilage as the target, the fluorescent on-state behavior enables accurate and rapid detection of these targets. The target is then loaded onto a test strip to prepare a fluorescent label, enabling freshness detection of actual food samples at room temperature using the solution / test strip. Furthermore, for further convenience and practicality, an intelligent detection method has been constructed.

The invention provides a phenothiazine derivative as well as a synthesis method and application thereof in food freshness detection. The invention designs and synthesizes a fluorescent molecule based on a phenothiazine derivative with proton / deprotonation behavior, the protonated phenothiazine derivative is taken as a detection object, 1, 4-butanediamine and 1, 5-pentamethylene diamine generated in a food spoilage process are taken as detected objects, accurate and rapid detection is realized through a fluorescence opening behavior, and the detection sensitivity is high. And then the fluorescent label is prepared by loading the fluorescent label on a test strip, so that the freshness of an actual food sample is detected by the solution / test paper at normal temperature. In addition, in order to be convenient and practical, an intelligent detection method is constructed.

Provided is a method for using a phenothiazine derivative compound, in which, in a synthetic polymer material produced by addition polymerization of a polymerizable unsaturated monomer, the polymerizable unsaturated monomer constituting the material is copolymerized with a phenothiazine derivative compound represented by general formula [I] in order to prevent oxidative degradation of the synthetic polymer material. The compound can be copolymerized with various polymerizable unsaturated monomers because the specific polymerization inhibition effect of the phenothiazine compound is reduced. In the general formula [I], R1 is a monovalent aliphatic hydrocarbon group having 1-10 carbon atoms, and R2 is a hydrogen atom or a methyl group.

The invention provides a charging self-balancing battery without a protection plate and a preparation method thereof, and belongs to the technical field of batteries, the charging self-balancing battery comprises the following components: lithium iron phosphate positive electrode slurry, graphite negative electrode slurry and a lithium ion battery electrolyte; the lithium ion battery electrolyte comprises the following raw materials in percentage by mass: 76-88% of an organic solvent, 10-16% of lithium salt, 1.5-5% of a film-forming additive and 0.5-3% of a redox shuttle agent, the redox shuttle agent comprises one or a combination of more than two of a phenanthroline complex of Fe, Ru, Ir and Ce and a derivative thereof, a bipyridine complex of Fe, Ru, Ir and Ce and a derivative thereof, thianthrene and a derivative thereof, a methoxybenzene compound, a dimethoxybenzene compound and a phenothiazine derivative. According to the technical scheme provided by the invention, the series battery pack is endowed with a charging self-balancing function without a protection plate, the mass energy density and the volume energy density of the battery pack are improved, and the cost and potential safety hazards are reduced.

The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.

The disclosures herein relate to novel compounds of the formula (1) such as e.g. 1H-pyridazino[4,3-e][1,3,4]thiadiazine and spiro[cyclopropane-1,5'-pyridazino[4,3-e][1,3]thiazine] derivatives, as GPR65 agonists for the treatment of inflammatory diseases including inflammatory bowel disease (IBD), atopic dermatitis (AD) and asthma; treatment of bone resorption diseases, including osteoporosis; neuroinflammatory disorders, including multiple sclerosis (MS).