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Beautyberry leaf injection with astringency and hemostasis effects and preparation method thereof

A technology of astringent hemostasis and Zizhucao, applied in the field of Zizhucao injection and its preparation, can solve the problems of easy to cause further infection, insignificant hemostatic effect, inconvenient use, etc., and achieve low cost of medicinal materials and easy availability of medicine sources , the effect of reducing the burden

Inactive Publication Date: 2014-10-29
付丽娜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are still some deficiencies in the existing technology including the above patent documents. Some existing hemostatic materials and tampons are more suitable for local small amount of bleeding, and generally have poor permeability, which is easy to cause further infection
The hemostatic effect is not significant, and it is inconvenient to use

Method used

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  • Beautyberry leaf injection with astringency and hemostasis effects and preparation method thereof
  • Beautyberry leaf injection with astringency and hemostasis effects and preparation method thereof
  • Beautyberry leaf injection with astringency and hemostasis effects and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 The preparation steps of Zizhucao injection with astringent and hemostatic effects are as follows:

[0035] (1) Take the coarse powder of Zizhucao, extract it twice with water, boil for 1 hour each time, combine the two filtrates, concentrate to a thick paste, add ethanol, stir well, wash, separate on the distribution funnel, discard the ethanol Mother liquor, precipitation, and drying below 60°C to obtain dry powder of crude water extract;

[0036] (2) Take the crude dry powder obtained in step (1), dissolve it with a small amount of water for injection, add lead acetate, stir well, put it in the refrigerator overnight, separate and precipitate to obtain a light yellow solution, add 50% sulfuric acid dropwise to adjust pH 1 to remove lead, filter To obtain a light yellow solution, add 2N sodium carbonate dropwise to bring the pH to 6.5, add 5 times the amount of 65% ethanol to precipitate out, discard the mother liquor, and dry below 60°C to obtain a white ...

Embodiment 2

[0040] Example 2 The preparation steps of Zizhucao injection with astringent and hemostatic effects are as follows:

[0041] (1) Take the coarse powder of Zizhucao, extract it twice with water, boil for 2 hours each time, combine the two filtrates, concentrate to a thick paste, add ethanol, stir well, wash, separate on the distribution funnel, and discard the ethanol Mother liquor, precipitation, and drying below 60°C to obtain dry powder of crude water extract;

[0042] (2) Take the crude dry powder obtained in step (1), dissolve it with a small amount of water for injection, add lead acetate, stir well, put it in the refrigerator overnight, separate and precipitate to obtain a light yellow solution, add 50% sulfuric acid dropwise to adjust pH 2 to remove lead, filter To obtain a light yellow solution, add 2N sodium carbonate dropwise to bring the pH to 6.5, add 5 times the amount of 65% ethanol to precipitate out, discard the mother liquor, and dry below 60°C to obtain a w...

Embodiment 3

[0048] Example 3 The preparation steps of Zizhucao injection with astringent and hemostatic effects are as follows:

[0049] (1) Take the coarse powder of Zizhucao, extract it twice with water, boil for 1.2 hours each time, combine the two filtrates, concentrate to a thick paste, add ethanol, stir well, wash, separate on the distribution funnel, discard the ethanol Mother liquor, precipitation, and drying below 60°C to obtain dry powder of crude water extract;

[0050] (2) Take the crude dry powder obtained in step (1), dissolve it with a small amount of water for injection, add lead acetate, stir well, put it in the refrigerator overnight, separate and precipitate to obtain a light yellow solution, add 50% sulfuric acid dropwise to adjust pH 1 to remove lead, filter To obtain a light yellow solution, add 2N sodium carbonate dropwise to bring the pH to 6.5, add 5 times the amount of 65% ethanol to precipitate out, discard the mother liquor, and dry below 60°C to obtain a whi...

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Abstract

The invention discloses a beautyberry leaf injection with astringency and hemostasis effects. Each 100ml of beautyberry leaf injection comprises the following main ingredients: 6-10g of beautyberry leaf aqueous extract and 3-12g of pseudo-ginseng aqueous extract. The beautyberry leaf injection has the functions of removing blood stasis and hemostasis, diminishing swelling for analgesic therapy, diminishing swelling to astringe dampness and diminishing inflammation for sterilization, and is capable of stopping bleeding in short time so as to effectively protect the wounds from secondary infection.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a Zizhucao injection with astringent and hemostatic effects and a preparation method thereof. Background technique [0002] In medicine, blood goes out from the heart and blood vessel cavity, which is called bleeding. Outflow of blood into body cavities or tissues is called internal bleeding, and blood out of the body is called external bleeding. Internal bleeding is generally not easy to find. It is manifested by vomiting blood and blood in the stool. Once found, seek medical attention immediately. Internal bleeding can occur in any part of the body. Those who accumulate blood in the body cavity are called hemocoelom, such as hemoperitoneum and hemopericardium; blood or clots can be seen in the body cavity. The hemorrhage that occurs in the tissue, when the amount is large, forms a hematoma, such as cerebral hematoma, subcutaneous hematoma, etc.; when the amount is ...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61K9/08A61P7/04
Inventor 付丽娜
Owner 付丽娜
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