Medicine for preventing and treating cachexia and application of medicine

Abstract

The invention provides a medicine which comprises an active components, namely, 3,5,6,7,3',4'-substituted flavone, for preventing and treating cachexia, and application of flavone in preparing a medicine for treating cancer cachexia. The in vivo experiment of mouse shows that after certain positions of a substituted flavone compound are chemically modified, weight loss and anorexia caused by malignant tumor induced cachexia are effectively inhibited, the body quality and muscle treatment are improved, the anorexia is alleviated, and the research result provides support for developing the flavone compound into a medicine for treating cachexia.

Description

technical field [0001] The invention relates to a flavonoid compound, in particular to a 3,5,6,7,3',4'-substituted flavone used for preparing a medicine for treating cancer cachexia and its application. Background technique [0002] Cancer cachexia is a multifactorial syndrome of progressive skeletal muscle loss with or without fat loss that cannot be reversed by conventional nutritional support. Cachexia patients have abnormal energy metabolism due to abnormal metabolism of sugar, protein and lipid in the body. Abnormal glucose metabolism is mainly manifested in enhanced insulin resistance, resulting in increased glucose synthesis, gluconeogenesis, and glucose-lactate cycle activity, and decreased glucose tolerance and turnover. Protein abnormalities include increased protein turnover, muscle catabolism, liver and tumor protein synthesis, and decreased muscle protein synthesis. Abnormal lipid metabolism is manifested by increased lipid mobilization, decreased lipogenesis ...

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Problems solved by technology

However, the above-mentioned drugs may be widely used because of their low efficacy and relatively large side effects.

Only progesterone preparations and glucocorticoid preparations are recommended by the Nursing Branch of the American Society of Oncology, and these two types of drugs, such as medroxyprogesterone and dexamethasone, only improve appetite and do not increase body weight or inhibit skeletal muscle. However, others, such as proteolytic agents, thalidomide, and betciferin, are not yet recommended for clinical application, and there are no examples of natural medicines being used in clinical treatment of cachexia.

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