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Compounds, extracts and uses isolated from Antrodia camphorata

A compound and extract technology, applied in the field of inhibiting tumor growth, can solve the problem that the compound has not been found.

Active Publication Date: 2016-10-19
曾卉菱
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although many current experiments show that the extract of Antrodia Cinnamomea has the aforementioned effects, and its components have been analyzed one after another, but whether there are still other compounds with anticancer activity or other medical uses in the extract of Antrodia Cinnamomea has not been found out , still needs further experimental research to clarify

Method used

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  • Compounds, extracts and uses isolated from Antrodia camphorata
  • Compounds, extracts and uses isolated from Antrodia camphorata
  • Compounds, extracts and uses isolated from Antrodia camphorata

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Experimental program
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Embodiment Construction

[0018] Take Antrodia camphorata (Antrodia camphorata) mycelia, fruiting bodies or a mixture of the two (1.0kg) and extract twice with 10 times the amount of alcohol, combine and concentrate to obtain about 230g of crude extract (LT-E), crude extract Dichloromethane / water (1:1) was used for partition extraction three times, divided into about 102.6g of dichloromethane layer (LT-E-D) and about 127.4g of water layer (LT-E-W), and 6.0 g of dichloromethane layer was taken g is separated into ANCA-E-D-1, ANCA-E-D-1, ANCA-E-D- 2. Four floors including ANCA-E-D-3 and ANCA-E-D-4.

[0019] Anticancer Activity of Antrodia Antrodia Extract

[0020] A549 cell line (lung adenocarcinoma), CT26 cell line (colon cancer), DU145 cell line (prostate cancer), HepG2 cell line (liver cancer), MDCK cell line (kidney cancer), PC3 cell line (prostate cancer) For the cell viability assay (MTT cell viability assay), see the results in Tables 1-6 below.

[0021] The above cell lines were respectively c...

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Abstract

The invention discloses a compound isolated from Antrodia camphorate and shown as formula I. Specifically, R1 is hydrogen or acetyl. The invention further discloses application of the compound to preparation of drugs for inhibiting tumor growth, wherein the tumor can be one of lung adenocarcinoma, colon cancer, prostate cancer and liver cancer.

Description

technical field [0001] The present invention relates to a compound isolated from Antrodia camphorata, its extract and its use, especially the use of the compound and its extract to inhibit tumor growth. Background technique [0002] Antrodia camphorata (Antrodia camphorata), also known as Antrodia camphorata, Antrodia camphorata or Red Antrodia, belongs to the perennial fungi of the order Aphyllophorales and the family Polyporaceae. On the inner wall of the hollow decaying heartwood of Taiwan's conservation tree species - Cinnamoum kanehirai Hay. Due to the extremely rare distribution of Cinnamomum camphora and human-made poaching, the number of wild Antrodia camphorata parasitic in it is even rarer, and because its fruiting body grows very slowly, the growth period is only between June and October. , and therefore very expensive. [0003] The fruiting body of Antrodia cinnamomea is perennial, sessile, corky to woody, with a strong camphor tree aroma, and its shape is vari...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C49/753C07C69/18A61K31/122A61K31/22A61K36/06A61P35/00
CPCA61K36/06C07C49/753C07C69/18C07C2601/16
Inventor 曾卉菱张温良姚振文严逸钊曾宛平曾泰霖郭盈妤
Owner 曾卉菱