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Controlled release medicinal insect bite and sting patch

A technology for controlled release of drugs and mosquitoes, applied in the field of external medicine, can solve the problems of poor and short efficacy, easy to pollute clothes, etc., and achieve the effects of long-lasting drug efficacy, long-lasting effect, and improvement of pigmentation degree and scar formation rate.

Inactive Publication Date: 2014-12-10
韩晓明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a controlled-release drug mosquito bite patch, which fundamentally solves the problems of easy contamination of clothes, drug action time, and short efficacy of existing anti-mosquito bite drugs.

Method used

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  • Controlled release medicinal insect bite and sting patch
  • Controlled release medicinal insect bite and sting patch
  • Controlled release medicinal insect bite and sting patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] like figure 1 , figure 2 As shown, the controlled-release drug mosquito bite patch includes a base layer 4, an adhesive layer 1 disposed on the base layer 4, and a drug layer disposed on the base layer. The drug layer includes a controlled-release drug layer arranged in the middle of the upper surface of the base layer 4, and an antipruritic layer 2 arranged on the outer edge of the controlled-release drug layer. The controlled-release drug layer includes a sustained-release layer 3 disposed near the base layer 4 and an immediate-release layer 5 disposed on the sustained-release layer 3 .

[0017] Taking the circular base layer as an example, the diameter of the base layer is preferably set to 1.5 cm, the diameter of the controlled-release drug layer is 0.5 cm, and the outer edge of the antipruritic layer is 0.5 cm from the outer edge of the base layer. The particle size of the drug particles in the sustained-release layer is preferably 200-300 nm, and the particle s...

Embodiment 2

[0030] The difference between this embodiment and embodiment 1 is only the content of each component.

[0031] The immediate-release layer includes the following medicines in proportion by weight: 10 parts of sodium bicarbonate, 5 parts of antibiotics and 4 parts of transdermal agent.

[0032] The antibiotic is selected from one or a mixture of levofloxacin, mupirocin, clindamycin, furazolidone and polymyxin.

[0033] The transdermal agent consists of menthol, propylene glycol and azone in a weight ratio of 1:1:1.

[0034] The release layer includes the following medicines in proportion by weight: 20 parts of sodium bicarbonate, 6 parts of antibiotics, 3 parts of plasticizer, and 5 parts of transdermal agent.

[0035] The antibiotic is selected from one or a mixture of levofloxacin, mupirocin, clindamycin, furazolidone and polymyxin.

[0036] The plasticizer is selected from diethyl phthalate or / and dibutyl phthalate.

[0037] The transdermal agent consists of menthol, prop...

Embodiment 3

[0043] like image 3 As shown, the controlled-release drug mosquito bite patch includes a base layer 4 , an adhesive layer 1 disposed on the base layer, and a drug layer disposed on the base layer 4 . The drug layer includes an anti-itch layer 2 arranged in the middle of the upper surface of the base layer 4, and a controlled-release drug layer arranged on the outer edge of the anti-itch layer 2. The controlled-release drug layer includes a sustained-release layer 3 disposed near the base layer 4 and an immediate-release layer 5 disposed on the sustained-release layer 3 .

[0044] The immediate-release layer includes the following medicines in proportion by weight: 8 parts of sodium bicarbonate, 4 parts of antibiotics, and 3 parts of transdermal agents.

[0045] The antibiotic is selected from one or a mixture of levofloxacin, mupirocin, clindamycin, furazolidone and polymyxin.

[0046] The transdermal agent consists of menthol, propylene glycol and azone in a weight ratio o...

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Abstract

The invention relates to a controlled release medicinal insect bite and sting patch. The controlled release medicinal insect bite and sting patch comprises a substrate, an adhesive layer arranged on the substrate and a medicine layer arranged on the substrate. The controlled release medicinal insect bite and sting patch has the technical key points that the medicine layer comprises a controlled release medicine layer arranged at the middle part of the upper surface of the substrate and an itching relieving layer which is arranged at the periphery of the controlled release medicine layer or surrounded by the controlled release medicine layer; and the controlled release medicine layer comprises a controlled release layer arranged at one side close to the substrate and a quick release layer arranged on the controlled release layer. The controlled release medicinal insect bite and sting patch can be used for fundamentally solving the problems that the existing insect bite and sting resistant medicine can pollute clothes easily, action time is short and pharmacological effect is poor, is simple in structure and has the advantages of long action time, controllable medicine release time, full play of pharmacological effect, convenience in application and no pollution produced to the clothes.

Description

technical field [0001] The invention relates to the field of external medicine, in particular to a mosquito bite patch for controlled release medicine. Background technique [0002] The physiological and pathological reaction process after mosquito bites is as follows: mosquito bite→inject acidic substances, anticoagulant substances and bacteria into the human body→acidic substances stimulate the body to release histamine→inflammation-mediated white blood cells release kinin to produce inflammation or allergy sexual response. After the mosquito bites, it injects acidic and anticoagulant substances into the skin through its mouthparts, and brings bacteria into the human body while causing skin pain. ~3h) can also cause allergic reactions or induce inflammation, and even induce infection. Due to inflammation and allergic reactions, 30-40% of the population will develop pigmentation and scars at the bite site, seriously affecting the appearance of the skin. In order to solve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K45/00A61P17/02
Inventor 韩晓明
Owner 韩晓明