Application of trehalose in preparation of skin-care product for preventing or treating ultraviolet injury

A technology of trehalose and ultraviolet rays, applied in the field of marine biology

Inactive Publication Date: 2015-01-28
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no literature report that trehalose has the effect of preventing or treating ultraviolet damage, especially the effect of anti-UVB

Method used

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  • Application of trehalose in preparation of skin-care product for preventing or treating ultraviolet injury
  • Application of trehalose in preparation of skin-care product for preventing or treating ultraviolet injury
  • Application of trehalose in preparation of skin-care product for preventing or treating ultraviolet injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1: A kind of trehalose ultraviolet ointment

[0054] 1. The formula of trehalose ultraviolet ointment

[0055] Water phase: 100g of ointment base contains 15g of liquid paraffin, 0.1g of ethyl Nepalese ester, 0.2g of triethanolamine, 0.2g of sodium lauryl sulfate, and 10g of glycerin; 1g of trehalose (high-dose trehalose group) or 0.5g Trehalose (low dose group), make up 80g with distilled water.

[0056] Oil phase: 5 g of glyceryl monostearate, 10 g of monostearic acid, and 5 g of petrolatum.

[0057] Two, the preparation method of trehalose ultraviolet ointment

[0058] The trehalose ultraviolet ointment is prepared by the oil-in-water emulsion preparation method. The specific method is: the water phase and the oil phase in the ointment components are respectively heated in a boiling water bath, so that the respective components are fully dissolved to form a uniform liquid. When the temperature of both the water phase and the oil phase reaches about 65°C, ...

Embodiment 2

[0059] Embodiment 2: the protective effect of the trehalose ultraviolet ointment prepared in embodiment 1 on the Kunming mice irradiated by UVB

[0060] 1. Grouping of experimental animals

[0061] Before the start of the experiment, 30 white male Kunming mice were adaptively fed for 2 days in a normal-grade animal breeding room in the same environment, with free access to food and water during the period. After the experiment started, 30 mice were digitally coded and randomly divided into 6 groups, with 5 mice in each group, marked as:

[0062] Modeling group: no trehalose ointment or ointment matrix was applied, and UVB irradiation was given;

[0063] Matrix group: apply ointment matrix and give UVB irradiation;

[0064] Trehalose low-dose group: apply 0.5% trehalose ultraviolet ointment and give UVB irradiation;

[0065] Trehalose high-dose group: apply ultraviolet ointment containing 1% trehalose, and give UVB irradiation;

[0066] Positive control group; apply commerc...

Embodiment 3

[0076] Embodiment 3: the protective effect of the trehalose ultraviolet ointment prepared in embodiment 1 on SD rats irradiated by UVB

[0077] 1. Grouping of experimental animals

[0078] Before the start of the experiment, 30 white male SD rats were adaptively raised in the animal breeding room with the same clean environment for 2 days, and they had free access to food and water during this period. After the start of the experiment, 30 rats were coded with numbers and randomly divided into 6 groups with 5 rats in each group. The grouping method was the same as that in the first part of Example 2.

[0079] 2. UVB irradiation method for experimental animals

[0080] Use electric pushing to remove the back hair of about 3cm×5cm area on the back of rats in all groups. The remaining fine hairs that are not easy to remove are smeared with depilatory cream and wiped off. UVB irradiation should not be given on the day of hair removal. After the experiment starts, every 3 days Rat...

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Abstract

The invention relates to the technical field of marine organisms. Trehalose is disaccharide formed by condensing two glucose molecules by 1,1-hemiacetal hydroxy, has excellent water solubility, belongs to non-reducing disaccharide, and has stable property. The invention provides a trehalose anti-ultraviolet ointment. According to the optimal formula, the ointment is oil-in-water ointment prepared from 1 percent of trehalose, 20 percent of oil-soluble base, 25.5 percent of water-soluble base and the balance of distilled water. The invention further provides application of the trehalose anti-ultraviolet ointment in preparation of a medicine or skin-care product for preventing or treating ultraviolet injury. Animal experiments prove that the trehalose ointment has a good effect of protecting mouse and rat skin injuries caused by ultraviolet ray, in particularly UVB.

Description

technical field [0001] The invention relates to the technical field of marine organisms, in particular to the application of trehalose in the preparation of skin care products for preventing or treating ultraviolet damage. Background technique [0002] Trehalose, chemical name α-D-glucopyranosyl-α-D-glucopyranoside, is a disaccharide formed by condensation of two glucose molecules through 1,1-hemiacetal hydroxyl. According to the configuration of the hemiacetal hydroxyl group, trehalose can be divided into three types, namely αα type, αβ type and ββ type, and their chemical structural formulas are shown in formulas (I), (II) and (III) respectively. [0003] [0004] Trehalose has good water solubility and non-reducing properties, and can act as an osmotic agent and anti-stress agent; at the same time, trehalose has biological stress resistance. Studies have found that under dry and slow freezing conditions, trehalose can prevent the phase transition of biofilms and avoid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7016A61K8/92A61K8/60A61P17/16A61Q17/04
CPCA61K31/7016A61K8/60A61K9/0014A61K9/06A61Q17/04A61Q19/004
Inventor 刘小宇奚悦张建鹏高云卢小玲焦炳华
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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