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A kind of hyaluronic acid composite cross-linked hydrogel and preparation method thereof

A technology of hyaluronic acid and compound cross is applied in the field of preparation of biomedical materials, which can solve the problems of poor stability, excessive hydrophilicity and easy degradation, and achieve good stability, high dynamic viscosity and good biocompatibility. sexual effect

Inactive Publication Date: 2017-06-06
TIANJIN UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, natural hyaluronic acid has shortcomings such as short half-life, poor stability, excessive hydrophilicity and easy degradation, which limit the wide application of HA.

Method used

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  • A kind of hyaluronic acid composite cross-linked hydrogel and preparation method thereof
  • A kind of hyaluronic acid composite cross-linked hydrogel and preparation method thereof
  • A kind of hyaluronic acid composite cross-linked hydrogel and preparation method thereof

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Embodiment Construction

[0032] specific implementation

[0033] In order to understand the present invention, the present invention will be further described below in conjunction with embodiment: following embodiment is illustrative, not limiting, can not limit protection scope of the present invention with following embodiment.

[0034] The specific components of the composite cross-linked hyaluronic acid hydrogel provided by the invention are:

[0035] (1) Hyaluronic acid 2-6g / 100mL;

[0036] (2) 1,4-Butanediol diglycidyl ether (BDDE) 40~200μL / 100mL;

[0037] (3) PEG6000 0.02~0.6g / 100mL;

[0038] (4) Sodium alginate 0.002~0.2g / 100mL;

[0039] ⑸Gelatin 0.002~0.2g / 100mL.

[0040] The hyaluronic acid composite cross-linked hydrogel provided by the present invention is prepared according to the following steps:

[0041] (1) Accurately weigh hyaluronic acid, PEG6000 and sodium alginate powder into a clean beaker;

[0042] (2) dissolving gelatin in water to obtain gelatin solution;

[0043] (3) Me...

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Abstract

The invention relates to hyaluronic acid composite cross-linked hydrogel and a preparation method thereof. By combining the characteristic that an active group of hyaluronic acid can be used as a chemical modification site with the characteristic of polyanion electrolyte of hyaluronic acid, different groups and different spatial conformations of the substances such as 1,4-butanediol diglycidyl ether, polyethylene glycol, sodium alginate and gelatin are utilized to perform composite crosslinking and modifying with hyaluronic acid, and the proportion of each component is analyzed to determine the optimum formula of each component in the crosslinking reaction; the molecular weight of the prepared hyaluronic acid composite hydrogel is obviously increased, especially, the dynamic viscosity of the prepared hyaluronic acid composite hydrogel is remarkably increased. The hyaluronic acid composite cross-linked hydrogel prepared by the preparation method disclosed by the invention is great in molecular weight and great in dynamic viscosity, has the advantages of relatively strong space blocking effect and lubricating effect, good biocompatibility, good stability, and the like, and can be used for a tissue filling material, a lubricant in an articular cavity and a tissue adhesion preventing material of operation.

Description

technical field [0001] The invention belongs to the field of preparation of biomedical materials, and relates to a hyaluronic acid composite crosslinked hydrogel and a preparation method thereof. [0002] technical background [0003] Hyaluronic acid (HA for short), also known as hyaluronic acid, is a macromolecular viscous polysaccharide composed of D-glucuronic acid and β-N-acetylglucosamine as structural units, through β-1,3 glycosidic bonds and β-1,4 glycosidic bonds are connected alternately, with an average relative molecular weight of 10 5 ~10 7 Da. Hyaluronic acid is an important component of skin, joint lubricants, cartilage and vitreous. Due to its unique rheological properties, lubricity, moisturizing function and biocompatibility, hyaluronic acid can be used in ophthalmic surgery, orthopedic surgery, treatment of osteoarthritis diseases and prevention of postoperative adhesions, etc. However, natural hyaluronic acid has shortcomings such as short half-life, po...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L5/08C08L71/08C08L5/04C08L89/00C08K5/1515C08J3/24C08J3/075A61L31/06A61L31/04A61L31/14
Inventor 杨洪江李梦菲孙庆惠
Owner TIANJIN UNIV OF SCI & TECH
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