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Leakage current sensing circuit for error detection in an improved capillary electrophoresis-electrospray ionization-mass spectrometry system

A technology of capillary electrophoresis and electrospray ionization, applied in the direction of spectrometer circuit layout, circuit, discharge tube, etc., can solve the problems of user safety hazards, reduced separation degree, and reduced effect of electrophoresis use classification

Active Publication Date: 2017-07-18
BECKMAN COULTER INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This heat and the resulting diffusion reduces the degree of separation and subsequent sorting for electrophoretic purposes
[0009] An additional complication is that the capillary electrophoresis system and the ESI-MS system are constructed as two separate systems that must be configured together to perform CE ESI-MS measurements
Different interfaces and different standards of connections between different types and brands of instruments lead to some interconnection problems, and if the connections are not set up properly, especially considering the high voltages involved in both systems, said interconnection problems can also pose a safety hazard to users

Method used

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  • Leakage current sensing circuit for error detection in an improved capillary electrophoresis-electrospray ionization-mass spectrometry system
  • Leakage current sensing circuit for error detection in an improved capillary electrophoresis-electrospray ionization-mass spectrometry system
  • Leakage current sensing circuit for error detection in an improved capillary electrophoresis-electrospray ionization-mass spectrometry system

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Embodiment Construction

[0025] The present invention relates to improved systems and methods for the integration of capillary electrophoresis (CE) and mass spectrometry (MS). In some embodiments, such a system provides an integrated structure for separating samples comprising, for example, protein complexes, proteins, peptides, polysaccharides or drugs / metabolites generally by CE and characterizing / identifying the separated molecules by MS . The invention herein is applicable in some embodiments to any capillary electrophoresis (CE) system coupled to a mass spectrometer (MS) system via electrospray ionization (ESI), and in other embodiments is configured with multiple MS Improved CE system for interfaces used with the system.

[0026] In particular, certain embodiments show improved systems that include current sensing circuitry that interfaces with the high voltage output of a MS ESI power supply to provide fault detection in a previously unknown manner.

[0027]The CE ESI-MS configuration circuit...

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Abstract

Aspects of the present invention relate to improved systems that can perform capillary electrophoresis (CE) combined with electrospray ionization (ESI) as input to a mass spectrometry system (MS). Embodiments may use a current sensing circuit at the high voltage output from the MS-ESI power supply in combination with some additional components to identify fault conditions related to leakage currents, identify CE connection continuity, and provide improved system protection.

Description

[0001] Cross references to related patent applications [0002] This patent application requires that the title submitted on June 4, 2012 be "LEAKAGE CURRENT SENSECIRCUIT FOR ERROR DETECTION IN AN IMPROVED CAPILLARY ELECTROPHORESIS-ELECTROSPRAY IONIZATION-MASS SPECTROMETRY SYSTEM (for improved capillary electrophoresis-electrospray ionization-mass spectrometry system Misdetected Leakage Current Sensing Circuit)" is the priority of U.S. Provisional Patent Application No. 61 / 655,433, which is hereby incorporated by reference in its entirety for all purposes. Background technique [0003] The present invention relates to electrophoresis, but also to capillary electrophoresis used in conjunction with electrospray ionization mass spectrometry. [0004] Electrophoresis is essentially the movement of charged particles within an applied electric field. Capillary electrophoresis (CE) is a known process. In capillary electrophoresis, a sample is injected at one end of a capillary. A ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/02H01J49/16G01N27/447G01R31/02G01R31/50
CPCG01N27/44713H01J49/022H01J49/165G01R31/50G01R31/52G01N27/44704
Inventor 彼得·S·高图斯基苏尼尔·S·黛利瓦拉斯蒂芬·A·弗赖伊
Owner BECKMAN COULTER INC