Chitosan gynecological gel and preparation method thereof

A technology of chitosan and gynecology, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, diseases, etc., can solve problems affecting the lives of patients, body injuries, etc., achieve good therapeutic effects, high activity, and simplify process steps Effect

Inactive Publication Date: 2015-02-11
JIANGSU MASLECH MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Although physical therapy used in the treatment of gynecological diseases can achieve certain curative effects, it will cause varying degrees of damage to the body and affect the normal life of patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A chitosan gynecological gel, the percentage content of each component is chitosan hydrochloride 1%, polyhexamethylene guanidine 0.02%, propylene glycol 3%, hydroxyethyl cellulose 2%, and the balance is Purified water, the preparation process is as follows:

[0021] (1) Weigh a certain amount of hydroxyethyl cellulose and prepare it into a gel;

[0022] (2) Weigh quantitative chitosan hydrochloride, polyhexamethylene guanidine, and propylene glycol, and prepare them into a mixed solution;

[0023] (3) Mix and stir the solutions prepared in steps (1) and (2), and add the remaining amount of purified water.

[0024] (4) Take a sample to measure the pH value and the content of each component, fill, sterilize, and package after passing the test to obtain the chitosan gynecological gel.

Embodiment 2

[0026] A chitosan gynecological gel, the percentage content of each component is chitosan acetate 3%, polyhexamethylene biguanide hydrochloride 0.1%, polyethylene glycol-2005%, carbomer 3 %, the balance is purified water, and the preparation process is as follows:

[0027] (1) Weigh the quantitative carbomer and prepare it into a gel;

[0028] (2) Weigh quantitative amounts of chitosan acetate, polyhexamethylene biguanide hydrochloride, and polyethylene glycol-200, and prepare them into a mixed solution;

[0029] (3) Mix and stir the solutions prepared in steps (1) and (2), and add the remaining amount of purified water.

[0030] (4) Take a sample to measure the pH value and the content of each component, fill, sterilize, and package after passing the test to obtain the chitosan gynecological gel.

Embodiment 3

[0032] A chitosan gynecological gel, the percentage content of each component is chitosan hydrochloride 1%, polyhexamethylene guanidine 0.02%, propylene glycol 3%, hydroxyethyl cellulose 2%, and the balance is Purified water, the preparation process is as follows:

[0033] (1) Weigh a certain amount of hydroxyethyl cellulose and prepare it into a gel;

[0034] (2) Weigh quantitative chitosan hydrochloride, polyhexamethylene guanidine, and propylene glycol, and prepare them into a mixed solution;

[0035] (3) Mix and stir the solutions prepared in steps (1) and (2), and add the remaining amount of purified water.

[0036] (4) Take a sample to measure the pH value and the content of each component, fill, sterilize, and package after passing the test to obtain the chitosan gynecological gel.

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PUM

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Abstract

The present invention discloses a chitosan gynecological gel, which comprises, by weight, 0.5-10% of a water-soluble chitin derivative, 0.01-0.5% of a guanidine antibacterial agent, 0.5-10% of a lubricating agent, 0.05-5% of a thickening agent, and the balance of purified water. According to the present invention, the chitosan gynecological gel does not require addition of the acidifying agent so as to simplify the process step, the guanidine antibacterial agent is added and the synergetic effect of the guanidine antibacterial agent and the water-soluble chitin derivative is adopted so as to achieve the long acting antibacterial effect, the treatment effect is good, no harm is produced on the body, and the body can not produce drug resistance during the use process.

Description

technical field [0001] The invention belongs to the technical field of medicinal chemistry, and in particular relates to a chitosan gynecological gel and a preparation method thereof. Background technique [0002] Although physical therapy adopted in the treatment of gynecological diseases can achieve certain curative effects, it will cause varying degrees of damage to the body and affect the normal life of the patient. Chitosan has antibacterial, anti-tumor, immune-enhancing and other functions, has good biocompatibility, and is non-irritating, non-toxic and side effects. Trichomonas vaginal disease, cervical erosion and other gynecological diseases have a good therapeutic effect. At present, during the preparation of most chitosan gels, acidifiers need to be added to form chitosan gels and adjust the pH of the gels. Contents of the invention [0003] Purpose of the invention: the purpose of the present invention is to provide a new chitosan gel, which can be prepared w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/722A61K47/34A61K47/38A61K47/32A61P15/02A61P31/02A61P33/02A61P31/10A61P15/00
Inventor 蔡信东
Owner JIANGSU MASLECH MEDICAL TECH
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