Preparation method of hyoscyamine in Flos Daturae Innoxiae

A technology of scopolamine and Beiyang, which is applied in the field of natural product preparation, can solve the problems of high toxicity and few clinical applications, and achieve the effects of low production cost, stable product quality and simple process

Inactive Publication Date: 2015-03-04
JIANGSU HANBON SCI & TECH CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hyoscyamine is a parasympathetic nerve inhibitor, and its pharmacological action is similar to that of atropine, but it is more toxic and has less clinical application

Method used

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  • Preparation method of hyoscyamine in Flos Daturae Innoxiae

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Experimental program
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Effect test

Embodiment 1

[0010] Alkalize 50 g of the concentrated extract of Beiyang Jinhua's ethanol impregnation solution to a pH of 9-10, and extract with 300 ml of chloroform. Adjust the pH of the alkaline water layer to 10 with ammonia water, extract three times with 300 ml of chloroform, combine the chloroform layers, and recover the chloroform. About 15 g of the chloroform extract was chromatographed on an alumina column, eluting with about 3 L of benzene-chloroform-isopropylamine as the mobile phase, separated and purified to obtain pure hyoscyamine with a purity of about 87%.

Embodiment 2

[0012] Alkalize 100 g of concentrated extract of Beiyang Jinhua's ethanol impregnation solution to a pH of 9-10, and extract with 600 ml of chloroform. The alkaline water layer was adjusted to pH 10 with ammonia water, extracted three times with 600 ml of chloroform, the chloroform layers were combined, and the chloroform was recovered. About 28 g of the chloroform extract was subjected to alumina column chromatography, and about 5 L of benzene-chloroform-isopropylamine was used as the mobile phase to elute, and the pure product of scopolamine was obtained by separation and purification, with a purity of about 88.6%.

Embodiment 3

[0014] Alkalize 200g of concentrated extract of Beiyang Jinhua's ethanol impregnation solution to a pH of 9-10, and extract with 1000ml of chloroform. Adjust the pH of the alkaline water layer to 10 with ammonia water, extract three times with 1000 ml of chloroform, combine the chloroform layers, and recover the chloroform. Pass about 50 g of the chloroform extract through alumina column chromatography, and use benzene-chloroform-isopropylamine as the mobile phase to elute about 12 L, separate and purify to obtain pure hyoscyamine with a purity of about 87.3%.

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Abstract

The invention discloses a preparation method of hyoscyamine in Flos Daturae Innoxiae. The preparation method is characterized by comprising the following steps: a crude product of hyoscyamine is extracted from Flos Daturae Innoxiae by a chemical method; by alumina column chromatography, benzene-chloroform-isopropylamine is used as a mobile phase to carry out elution; and separation purification is carried out to obtain a pure product of hyoscyamine. The method has advantages of simple technology and stable product quality.

Description

technical field [0001] The invention relates to the field of preparation of natural products, in particular to a method for preparing hyoscyamine from the golden flower of Beiyang. Background technique [0002] Hyoscyamine in Beiyangjinhua is a scopolane alkaloid. Molecular formula C17H23NO3. Also known as hyspinine. It is present in many important Chinese herbal medicines, such as belladonna, beiyangjinhua and datura. Colorless needle-like crystals. Hyoscyamine is a parasympathetic inhibitor, and its pharmacological action is similar to that of atropine, but it is more toxic and has less clinical application. Hyoscyamine has the function of relieving pain and spasm, and has a good effect on sciatica. Sometimes it is also used to treat epilepsy and seasickness. The structure of scopolamine is as follows: [0003] Contents of the invention [0004] The technical scheme adopted by the present invention for the purpose of the above invention is as follows: extract th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D451/10
CPCC07D451/10
Inventor 刘大伟张大兵王亚辉李胜迎金新亮周利娟
Owner JIANGSU HANBON SCI & TECH CO
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