Traditional Chinese medicine combination for treating bone injury and fracture and preparation method of traditional Chinese medicine combination
A composition and traditional Chinese medicine technology, applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc., can solve the problems of prolonged disease course and painful period of patients, slow effect of controlling symptoms, great pain in surgery, etc., and achieve early physiological healing period, callus Forms a rapid, high cure rate effect
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preparation example Construction
[0080] The preparation method of the external ointment of the present invention includes:
[0081] First, 1500g of Panax notoginseng, 1500g of Dragon's blood, 1500g of frankincense, 1500g of myrrh, 1500g of cinnamon and 1500g of Qianghuo are vaporized into crystals by distillation, crushed for later use, and then 1500g of the above ground maple peel, 1500g of safflower, 1500g of safflower, and horse money Seed 1500g, catechu 1500g, Chuanwu 1500g, cinnamon 1500g, Tougucao 1500g, Angelica 1500g, Tripterygium 1500g, Weilingxian 1500g, Earthworm 1500g, Scorpion 1500g, add 10 times the weight of the raw materials Soak in sesame oil for 7-10 days, heat to extract the active ingredients, boil on high fire, and reduce the fire power after the sesame oil boils, until the medicine is dark brown on the outside and burnt yellow inside, remove the medicine residue, continue to smelt the medicine, and stir constantly , The smoke turns from white to green, refining to dripping into beads; fry t...
experiment example 2
[0094] Experimental example 2: Cumulative toxicity test:
[0095] The traditional Chinese medicine preparation of the present invention was taken orally to the mice at 7.69, 19.18 and 43.21g crude drugs / kg for 15 weeks (1.0ml / 100g body weight, twice a day) for 15 weeks and 3 weeks after drug withdrawal, the results showed that: the traditional Chinese medicine of the present invention The preparation had no significant effect on the hair, behavior, urine and feces, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of rats. No abnormal changes were found in the organs by naked eyes. The results of histological examination showed that the medication 15 There were no obvious changes in the organs of the rats after weeks and 3 weeks after drug withdrawal. It shows that the oral capsule of the traditional Chinese medicine preparation of the present invention is less toxic to rats after long-term medication, and there is ...
experiment example 3
[0096] Experimental example 3: Acute transdermal toxicity test results
[0097] The externally used compound preparation of the medicine of the present invention has the effects of dispelling wind and dampness, promoting blood circulation and dredging collaterals, and is used for treating rheumatism, rheumatoid arthritis and other diseases. Based on this, an acute dermal toxicity test was first performed to observe whether the acute dermal toxicity of the drug to rats is actually non-toxic.
[0098] Test substance: the preparation ointment for external use of the present invention. Weigh 50g of the test substance and add distilled water to make a 50% paste for later use.
[0099] Experimental animals: 20 SD rats were provided by the Experimental Animal Center of Shandong Academy of Traditional Chinese Medicine, each half male and half male, weighing 180-220g, first-class animals (Yidong Zi No. 08-25), the source of feed is the same as above. Animal room environment: temperature: 22...
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