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Application of rhodiola rosea extract in preparation of medicine resistant to adverse effects during radiotherapy and chemotherapy

A technology of adverse reactions and extracts, applied in drug combinations, pharmaceutical formulations, plant raw materials, etc.

Inactive Publication Date: 2015-04-08
XINJIANG HUASHIDAN PHARMA RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report about the use of Rhodiola rosea extract as a drug for preparing anti-radiotherapy and chemotherapy-induced adverse reactions.

Method used

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  • Application of rhodiola rosea extract in preparation of medicine resistant to adverse effects during radiotherapy and chemotherapy
  • Application of rhodiola rosea extract in preparation of medicine resistant to adverse effects during radiotherapy and chemotherapy
  • Application of rhodiola rosea extract in preparation of medicine resistant to adverse effects during radiotherapy and chemotherapy

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Embodiment

[0016] The use of the Rhodiola rosea extract of the present invention in the preparation of medicines against adverse reactions caused by radiotherapy and chemotherapy can obtain the Rhodiola rosea extract by adopting the method of refining the macroporous adsorption resin after alcohol extraction, and the extract mainly includes Glycosides and flavonoids, mainly including salidroside, p-tyrosol, rosavin, rosarin and total flavonoids, The extracting and refining method of this Rhodiola rosea extract is carried out according to the following steps:

[0017]Extraction and refinement of Rhodiola rosea extract: take the dried Rhodiola rosea medicinal material and pulverize it, and pass through a No. 2 sieve; weigh 500g of medicinal material powder, add concentration and be 5%-95% ethanol for reflux extraction 1-3 times, and the amount of solvent added is 8-20 times, extract for 1-3 hours, filter the extract, combine and concentrate to a relative density of 0.8-1.2;

[0018] The r...

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Abstract

The invention relates to application of a rhodiola rosea extract in preparation of a medicine resistant to adverse effects during radiotherapy and chemotherapy. Rhodiola rosea is extracted by adopting alcohol and then is refined by virtue of macroporous adsorption resin, so that the rhodiola rosea extract is obtained; the rhodiola rosea extract mainly comprises glycoside and flavonoid ingredients, namely the following five ingredients: salidroside, p-tyrosol, rosavin, rosarin and total flavonoids; and a large number of tests show that the rhodiola rosea extract has an obvious therapeutic effect on a bone marrow suppression model and an immune inhibition model which are caused by radiotherapy and chemotherapy.

Description

technical field [0001] The invention relates to the use of Rhodiola rosea extract in preparing medicines for resisting adverse reactions of radiotherapy and chemotherapy, especially the application of resisting adverse reactions of myelosuppression or immune function suppression caused by radiotherapy and chemotherapy. Background technique [0002] Malignant tumor is one of the major diseases that seriously endanger people's health. According to a data released by the World Health Organization in July 2008, the number of people who died of cancer in 2007 reached 7.9 million, accounting for about 13% of the total number of deaths. The main types of cancer that caused death were: lung cancer (1.4 million people); stomach cancer (866,000 people); liver cancer (653,000 people); colon cancer (677,000 people) and breast cancer (548,000 people). About 80% of deaths from cancer occur in low- and middle-income countries. The number of deaths from cancer worldwide is projected to co...

Claims

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Application Information

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IPC IPC(8): A61K36/41A61P7/00A61P37/04
CPCA61K36/41
Inventor 马芹周凡范文玺陈伟马小琴郭亮
Owner XINJIANG HUASHIDAN PHARMA RES
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