A kind of production technology of film coating agent

A technology of film coating agent and production process, which is applied in the field of preparation of drug coating materials, can solve the problems of high heavy metal content and uneven particle size, and achieve the effect of uniform particle size, small particle size and good plasticizing effect

Active Publication Date: 2017-12-01
TIANJIN BOKELIN MEDICINE PACKAGING TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The invention provides a film coating agent production process, which solves the problems of high heavy metal content and uneven particle size in the film coating agent in the prior art

Method used

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  • A kind of production technology of film coating agent
  • A kind of production technology of film coating agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] 1. Add 850g of hydroxypropyl methylcellulose into the mixer, control the blade speed of the mixing equipment to 200 rpm, slowly add 60g of glycerin, and run the equipment for 6 minutes to achieve plasticization of the material.

[0059] 2. Put 90g of titanium dioxide into the mixer, control the blade rotation speed of the mixing equipment to 200 rpm, and mix the coated colorant for 10 minutes to form a mixture.

[0060] 3. The mixed material is put into the airflow mill, the compressed air pressure is 0.7MPa, the material is crushed by the airflow in the crushing chamber, and then discharged to obtain the finished coating agent with uniform color and particle size meeting the requirements.

Embodiment 2

[0062] 1. Add 610g of methylcellulose into the mixer, control the blade speed of the mixing equipment to 600 rpm, slowly add 160g castor oil, and run the equipment for 10.5 minutes to achieve plasticization of the material.

[0063] 2. Put 190g of titanium dioxide and 40g of sunset yellow lake into the mixer, control the blade rotation speed of the mixing equipment to 600 rpm, and mix the coated colorant for 15 minutes to form a mixture.

[0064] 3. The mixed material is put into the airflow mill, the compressed air pressure is 0.85MPa, the material is crushed by the airflow in the crushing chamber, and then discharged to obtain the finished coating agent with uniform color and particle size meeting the requirements.

Embodiment 3

[0066] 1. Add 300g of hydroxypropyl cellulose into the mixer, control the blade speed of the mixing equipment to 1000 rpm, slowly add 200g of triethyl citrate, and run the equipment for 15 minutes to achieve plasticization of the material.

[0067] 2. Put 150g of titanium dioxide and 350g of medicinal iron oxide into the mixer, control the rotation speed of the blades of the mixing equipment to 1000 rpm, and mix the coated colorant for 20 minutes to form a mixture.

[0068] 3. The mixed material is put into the airflow mill, the compressed air pressure is 1.0MPa, the material is crushed by the airflow in the crushing chamber, and then discharged to obtain the finished coating agent with uniform color and particle size meeting the requirements.

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Abstract

The invention relates to a production process of a film coating agent. The production method mainly uses high-pressure airflow to pulverize materials. In the prior art, there are problems of heavy metals and particle size of raw materials in the production process of film coating agents. The method of the invention has good crushing effect, and the particle size of the product is fine and uniform; the high-speed air flow can avoid thermal denaturation of the material; the detection of heavy metals in the finished coating agent meets the control requirements of the food and health product industries; and the production efficiency is higher.

Description

Technical field: [0001] The invention relates to a preparation method of a drug coating material, in particular to a production process of a film coating agent Background technique: [0002] Film coating is a new type of coating process, which is to spray polymer solution or suspension onto the surface of the tablet core to form a relatively stable plastic film layer with a thickness of several microns, so as to achieve a certain expected effect. The process is called film coating. When the tablet is running in the coating machine, very small droplets of the coating solution or suspension are sprayed onto the surface of the tablet core. After drying, a coating film is formed on the surface of the tablet core. [0003] According to different solvents, the film coating process can be divided into aqueous coating process and organic solvent coating process. The main purpose of film coating is to improve appearance and easy identification, mask bad smell, facilitate patients ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K47/32
Inventor 赵永建邵广川
Owner TIANJIN BOKELIN MEDICINE PACKAGING TECH
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