Application of morroniside to preparation of osteoarthritis treating drugs

Abstract

The invention discloses application of morroniside to preparation of osteoarthritis treating drugs and relates to application of the morroniside. The morroniside can be used for promoting the in-vitro cultured human osteoarthritis chondrocytes to survive, weakening the chondrocyte index of the chondrocytes, improving the expression levels of II type collagen and proteoglycan Aggrecan in extracellular matrixes of the in-vitro cultured human osteoarthritis chondrocytes, improving the phosphorylation levels of intracellular protein kinase B (PKB / Akt) and extracellular regulated protein kinase of the human osteoarthritis chondrocytes, effectively promoting the survival of the human osteoarthritis chondrocytes and weakening the apoptosis activity of the human osteoarthritis chondrocytes. According to the application, the injury of the osseous tissues in osteoarthritis models of experimental rats is effectively reduced, the cartilage layer thickness is increased and the extracellular polysaccharides content of the cartilage is improved.

Description

technical field [0001] The present invention relates to the application of morroniside, in particular to the application of morroniside in the preparation of medicines for treating osteoarthritis. Background technique [0002] Morroniside is an iridoid glycoside compound extracted from the pulp of Cornus officinalis Sieb.et Zucc at the earliest. Its molecular formula is C17H26O11. For the structural formula, see figure 1 , is one of the active ingredients of the traditional Chinese medicine Liuwei Dihuang Pills. Recently, scholars have found that it can also be extracted from many medicinal plants such as the stem and leaf of Lonicera macranthoides and the flower bud of Lonicera japonica. [0003] The current research results show that the main pharmacological effects of morroniside include: [0004] 1. Nerve cell protection: protect nerve cells under toxic conditions, or resist the effect of hydrogen peroxide-induced nerve cell apoptosis, so it is mostly used as a neuropr...

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Problems solved by technology

[0018] ①Cartilage component supplements: such as glucosamine, hyaluronic acid, etc., due to the decrease in the number of chondrocytes and the weakened synthesis function in osteoarthritis, these cartilage components cannot be effectively used and cannot achieve effective therapeutic effects

[0020] ③ Steroidal anti-inflammatory drugs mainly refer to corticosteroid drugs, because they have a common structural feature, that is, they are all steroids. Although steroidal drugs have excellent anti-inflammatory and analgesic effects, long-term use can cause watery symptoms. Severe disturbance of salt metabolism and sugar, fat, and protein metabolism

However, since it is a joint replacement therapy, the artificial joint metal prosthesis has a certain working life, which is not suitable for young and middle-aged patients and early and middle-term patients.

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