CdSe/ZnS quantum dot-modified quercetinantibacterial agent and preparation method thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
An antibacterial drug, quercetin technology, applied in the field of medicine, can solve problems such as defects, unsatisfactory clinical effects, and obstacles to the development of quercetin, and achieve low surface tension, low toxicity, and good invasiveness
Inactive Publication Date: 2015-05-20
ANHUI AGRICULTURAL UNIVERSITY
View PDF1 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, due to the defects of quercetin's physical and chemical properties, especially the solubility and targeting of quercetin, its clinical effect is not particularly ideal, which seriously hinders the development of quercetin as a drug
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0029] The particle size, fluorescence intensity and distribution of the present invention and the in vitro antibacterial effect of the medicament of the present invention are further described below through the test examples.
[0030] A quercetin antibacterial drug modified by CdSe / ZnS quantum dots, the drug is composed of the following raw materials in weight percentage:
[0031] Quercetin 30%-40%
[0032] CdSe / ZnS core-shell quantum dots 60%-70%
[0033] As mentioned above, the preparation method of quercetin antibacterial drug is as follows:
[0034] A, the preparation of precursor NaHSe
[0035] Add 1 mL of ddH to the container with the magnetic rotor 2 O, respectively, 0.0399g NaBH 4 Add it to the container, close the bottle cap tightly to make it completely dissolved; then weigh 0.0395g of Se powder and add it to the container; when the reactant in the container changes from black to colorless, seal the container and place it under magnetic stirring On the reactor,...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses a CdSe / ZnS quantum dot-modified quercetinantibacterial agent and a preparation method thereof. The antibacterial agent comprises the following active ingredients in percentage by weight: 30%-40% of quercetin, and 60%-70% of CdSe / ZnS core-shell quantum dots; the preparation method comprises the following steps: firstly, preparing a precursor NaHSe from NaBH4 and Se powder, then adding quercetin and CdCl3.<2.5>H2O-containing mixed solution into the precursor NaHSe, and reacting to obtain quercetin-modified CdSe mononuclear quantum dots, finally, adding the quercetin-modified CdSe mononuclear quantum dots into the mixed solution dissolved with quercetin and ZnSO4.7H2O, then adding a solution prepared from Na2S.9H2O, refluxing for 1.5 hours at 100DEG C, to obtain the CdSe / ZnS quantum dot-modified quercetinantibacterial agent. According to the method, the CdSe / ZnS quantum dots are modified on the quercetin, and the agent has fluorescence, so that the agent can be intuitively observed on the aspect of clinical therapy.
Description
Technical field: [0001] The invention belongs to the field of medicine, and belongs to a new dosage form of antibacterial drugs, in particular to a quercetin antibacterial drug modified by CdSe / ZnS quantum dots and a preparation method thereof. Background technique: [0002] Quercetin belongs to flavonoids. Scholars at home and abroad have done a lot of research work on the extraction, purification, structure determination, physical and chemical properties, synthetic derivatives, pharmacology and clinical practice of quercetin. According to reports, quercetin has expectorant, cough, asthma, anti-inflammatory, anti-allergic, antispasmodic, cardiotonic, blood pressure lowering, dilating coronary artery, lowering blood fat, antiarrhythmia, antiplatelet aggregation, antioxidation, antitumor and other broad pharmacological effects. [0003] At present, with more and more types of diseases, the pharmacological effects of quercetin have been discovered by a large number of researc...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more