Preparation method of medicine for treating gastroesophageal reflux disease in gastroenterology department

A gastroesophageal reflux and drug technology, applied in the field of medicine, can solve the problems of high disease recurrence rate and large side effects, and achieve the effect of significant effect, improving rhythm disorder and regulating overall function.

Inactive Publication Date: 2015-05-27
蒋晓云
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine treatment of gastroesophageal reflux disease includes changing lifestyle, suppressing gastric acid, gastric motility drugs, etc. The curative effect is positive, but the side effects are large, and the recurrence rate of the disease is high after stopping the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0017] Diagnostic criteria

[0018] The diagnostic criteria for gastroesophageal reflux disease: adopt the RE endoscopy classification standard formulated by the Digestive Endoscopy Branch of the Chinese Medical Association in Jinan in 2003 (The Digestive Endoscopy Society of the Chinese Medical Association. Guidelines for the diagnosis and treatment of reflux esophagitis[J]. Chinese Journal of Digestive Endoscopy, 2004,21(4):221-222.) to formulate.

[0019] Inclusion criteria

[0020] (1) With clinical symptoms such as obvious acid reflux, heartburn and retrosternal pain or discomfort. (2) Esophageal mucosal damage seen under endoscopy. (3) Those who signed the informed consent form.

[0021] exclusion criteria

[0022] Patients with peptic ulcer, malignant lesions of upper gastrointestinal tract, scleroderma, diabetes, coronary heart disease and history of upper gastrointestinal surgery, lactating or pregnant women, poor compliance, and adverse events related to the expe...

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PUM

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Abstract

The invention relates to a preparation method of a pharmaceutical composition for treating gastroesophageal reflux disease in the gastroenterology department. The method comprises the following steps: weighing 120g of full-grass Desmodium caudatum, 120g of microlepia strigosa, 200g of clinopodium herb, 100g of balanophora mutinoides hayata, 250g of disinfectant, 120g of nothopanax delavayi, 100g of Japanese mazus herb, 100g of basella alba, 100g of swamp cudweed herb and 120g of hedyotis caudatifolia; adding 25,000ml of water; performing heating refluxfor 5 hours in a flask with a condensation pipe; filtering; cooling the filtrate to room temperature; adding absolute ethyl alcohol until the alcohol content is 85vol%; sealing and placing for 24 hours at room temperature; and filtering and completely recycling ethanol from the filtrate, thus obtaining the aqueous solution which is the target medicine.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation method of a pharmaceutical composition for treating gastroesophageal reflux disease in a gastroenterology department. Background technique [0002] The pathogenesis of gastroesophageal reflux disease is very complex, which may be related to the combination of defensive factors (anti-reflux barrier, esophageal acid clearance and mucosal resistance) and aggressive factors (acid pH value, acid secretion volume and duodenal content reflux). related to imbalance. The current Western medicine treatment of gastroesophageal reflux disease includes changing lifestyle, suppressing gastric acid, gastric motility drugs, etc., which have positive curative effect, but side effects are large, and the disease recurrence rate is high after drug withdrawal. Contents of the invention [0003] The purpose of the present invention is to provide a preparation method of the pharmaceutical compo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/86A61P1/04
Inventor 朱宁生
Owner 蒋晓云
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