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Animal immune adjuvant as well as preparation method and application method thereof

A technology of animal immunity and immune enhancer, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., to achieve the effect of enhancing reaction sensitivity, improving reaction sensitivity, and enhancing the probability of recognition

Inactive Publication Date: 2015-06-03
SUQIAN HENGRUI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the current adjuvants mainly improve the utilization rate of antigens through physical adsorption, separation and slow release, or stimulate the immune system with drugs and biological agents, but there are few adjuvants that directly modify the antigen to enhance the immune effect.

Method used

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  • Animal immune adjuvant as well as preparation method and application method thereof
  • Animal immune adjuvant as well as preparation method and application method thereof
  • Animal immune adjuvant as well as preparation method and application method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] In this embodiment, an animal immune adjuvant is prepared according to the following steps:

[0025] 1. Weigh raw materials: Weigh 70g liquid paraffin, 31g lanolin, 0.1g Span-80, 0.3g BCG, 0.3g muramyl dipeptide, 4g levamisole and 3g nano-sized hydroxyapatite;

[0026] 2. Add liquid paraffin, lanolin, Span-80, nano-sized hydroxyapatite, levamisole, and muramyl dipeptide while mixing in order, and then stir at 2000-4000r / min for 20-30min;

[0027] 3. Heat the stirred material with steam to 120-130°C and then sterilize it for 20-40 minutes;

[0028] 4. After cooling the sterilized adjuvant, add BCG and mix well to obtain the animal immune adjuvant.

Embodiment 2

[0030] In this embodiment, an animal immune adjuvant is prepared according to the following steps:

[0031] 1. Weigh raw materials: Weigh 68g liquid paraffin, 20g lanolin, 2g Span-80, 0.05g BCG, 0.7g muramyl dipeptide, 5g levamisole and 1.2g nano-sized hydroxyapatite;

[0032] 2. Add liquid paraffin, lanolin, Span-80, nano-sized hydroxyapatite, levamisole, and muramyl dipeptide while mixing in order, and then stir at 2000-4000r / min for 20-30min;

[0033] 3. Heat the stirred material with steam to 120-130°C and then sterilize it for 20-40 minutes;

[0034] 4. After cooling the sterilized adjuvant, add BCG and mix well to obtain the animal immune adjuvant.

Embodiment 3

[0036] In this embodiment, an animal immune adjuvant is prepared according to the following steps:

[0037] 1. Weigh raw materials: Weigh 60g liquid paraffin, 35g lanolin, 0.6g Span-80, 0.24g BCG, 0.1g muramyl dipeptide, 2g levamisole and 2.5g nano-sized hydroxyapatite;

[0038] 2. Add liquid paraffin, lanolin, Span-80, nano-sized hydroxyapatite, levamisole, and muramyl dipeptide while mixing in order, and then stir at 2000-4000r / min for 20-30min;

[0039] 3. Heat the stirred material with steam to 120-130°C and then sterilize it for 20-40 minutes;

[0040] 4. After cooling the sterilized adjuvant, add BCG and mix well to obtain the animal immune adjuvant.

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PUM

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Abstract

The invention discloses an animal immune adjuvant as well as a preparation method and an application method thereof, relates to a medical preparation characterized in an immunostimulation additive, in particular to an immunostimulation additive for animals, and aims at providing an animal immune adjuvant which is free of a toxic or side effect and is used for directly modifying the antigen-reinforced immune effect, and a preparation method and an application method of the animal immune adjuvant. The animal immune adjuvant comprises an oil agent and an immunoenhancer; the oil agent comprises liquid paraffin and a surfactant; the surfactant comprises lanolin and span-80; and the immunoenhancer comprises a bacillus calmette guerin vaccine, muramyl dipeptide, levomisole and nanoscale hydroxyapatite. The animal immune adjuvant prepared by the method is capable of effectively inducing cellular immunity and humoral immune response of antigenic specificity; and the antibody with high valence and high sensitivity is obtained by kinds of modifications. The animal immune adjuvant is applied to the fields of immunology and in vitro diagnosis.

Description

technical field [0001] The invention relates to a medical preparation characterized by an immune stimulating additive, in particular to an immune stimulating additive for animals. Background technique [0002] Immunological adjuvants, also known as adjuvants or antigenic adjuvants, are generally non-immunogenic when used alone, but can enhance the immunogenicity of antigenic substances when used in combination with antigenic substances (injected together with antigens or pre-injected into the body). The body's immune response, or a substance that changes the type of the body's immune response. [0003] Commonly used adjuvants can be divided into 4 categories: inorganic adjuvants, such as aluminum hydroxide, alum, etc.; organic adjuvants, microorganisms and their products such as mycobacteria (Mycobacterium tuberculosis, BCG), Brevibacterium, pertussis bacillus, endotoxin, Bacterial extracts (muramoyl dipeptide), etc.; synthetic adjuvants, such as artificially synthesized do...

Claims

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Application Information

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IPC IPC(8): A61K39/39A61K39/04A61P37/04A61P31/06
Inventor 吴凡
Owner SUQIAN HENGRUI BIOTECH
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