Kit for detecting treponema pallidum antibody as well as detection method and application thereof
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A Treponema pallidum and kit technology, which is applied in biological tests, measuring devices, material testing products, etc., can solve problems such as low sensitivity and poor specificity, and achieve the effect of improving detection sensitivity
Active Publication Date: 2015-06-10
SHENZHEN NEW INDS BIOMEDICAL ENG
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[0011] However, TP detection in conventional techniques often has the problems of low sensitivity and poor specificity
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Embodiment 1
[0061] The source of the Syphilis recombinant antigen CMIA-TP-Ag8 in Example 1: Fapon Company.
[0062] The source of the Syphilis recombinant antigen CMIA-TP-Ag2 in Example 1: Fapon Company.
Embodiment 4
[0063] The source of the Syphilis recombinant antigen Tpp15 in Example 4: Fapon Company.
[0064] The source of the Syphilis recombinant antigen Tpp17 in Example 4: Fapon Company.
[0065] The source of the Syphilis recombinant antigen Tpp47 in Example 4: Fapon Company.
[0066] Staphylococcus aureus protein A (SPA) in Example 4, source: Yawei Company.
[0113] A test kit for detecting Treponema pallidum antibody, which is basically the same as the test kit in Example 1, except that:
[0114] 4) The specific additive only contains buffer components, without binding agents and auxiliary components.
[0115] A method for detecting Treponema pallidum antibody is basically the same as the detection method in Example 1, except that the detection kit of this embodiment is used for detection.
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Abstract
The invention discloses a kit for detecting a treponema pallidum antibody as well as a detection method and an application thereof, and belongs to the technical field of in vitro diagnosis and detection. The kit consists of the following components: (1) a marker system: including a treponema pallidum recombinant antigen 1 in direct or indirect connection to a marking tracer, or staphylococcus aureus A protein in direct or indirect connection to the marking tracker; (2) a bridged compound system: including a treponema pallidum recombinant antigen 2 in direct or indirect connection to a first bridged compound; and (3) a magnetic microsphere system: comprising a magnetic microsphere in direct or indirect connection to a second bridged compound, wherein the first bridged compound is combined with the second bridged compound. The kit and the detection method disclosed by the invention can promote the full implementation of conjugation reaction between antigen and antibody; and detection sensitivity can be improved.
Description
technical field [0001] The invention relates to the technical field of in vitro diagnosis and detection, in particular to a kit for detecting Treponema pallidum antibody, a detection method and application thereof. Background technique [0002] Syphilis is a chronic, systemic sexually transmitted disease caused by Treponema pallidum. Also known as Treponemia pallidum (TP), it was discovered and reported by French scientists Schaudinn and Hoffmanu in 1905. In taxonomy, it belongs to Spirochaetales, Treponemataceae, and Genus Treponema. The bacteria are slender, with 6 to 12 helices evenly arranged, 5 to 20 μm long, with an average length of 6 to 10 μm, and a transverse diameter of 0.15 μm or so. The movement is slow and regular. The dyes commonly used in the laboratory are not easy to color, and dark field microscopy can be used Or observe the bacteria with a phase contrast microscope. It is mainly transmitted through sexual channels, and clinically it can be manifested as...
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