Compound combined medicine for treating ulcerative colitis and preparation method and application thereof

Abstract

The invention discloses a compound combined medicine for treating ulcerative colitis. The compound combined medicine is prepared from the following components in parts by weight: 2-9 parts of coptis chinensis, 6-15 parts of scutellaria baicalensis, 10-30 parts of patrinia, 6-20 parts of fried angelica sinensis, 5-20 parts of parched white peony roots, 5-15 parts of raw garden burnets, 5-20 parts of lithospermum, 5-15 parts of madders, 6-15 parts of radix angelicae, 3-12 parts of simmered elecampane and 2-6 parts of raw liquorice. The invention further discloses a preparation method and application of the ompound combined medicine. The invention provides an effective therapeutic medicine for treating the refractory diseases ulcerative colitis and is economical and practical and broad in clinical application prospect. The compound combined medicine is simple in preparation method, simple, fast, efficient and easy to operate, and prepared granules are convenient to carry and take.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a compound medicine for treating ulcerative colitis and its preparation method and application Background technique [0002] Ulcerative colitis (UC) is a chronic non-specific inflammation that mainly involves rectal and colonic mucosa, and belongs to the category of inflammatory bowel disease. Its course of disease is characterized by chronicity, delay, recurrent attacks, and the possibility of canceration. Because of its unknown etiology, difficult to cure, and easy to relapse, it is listed as a difficult disease by the World Health Organization. [0003] At present, Western medicine treatment drugs for UC include: ①Aminosalicylic acid preparation, which is the current first-line drug, but sulfasalazine has obvious toxic and side effects; Taking for a long time, the curative effect of controlling recurrence is not ideal yet. ②Glucocorticoids: ...

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Problems solved by technology

[0003] At present, Western medicine treatment drugs for UC include: ①Aminosalicylic acid preparation, which is the current first-line drug, but sulfasalazine has obvious toxic and side effects; Long-term use, the curative effect of controlling recurrence is not satisfactory

②Glucocorticoids: mainly hydrocortisone succinate, prednisolone, methylprednisolone, etc., which are prone to drug dependence, have obvious side effects, and are difficult to use for a long time

③ Immunosuppressants: mainly cyclosporine, azathioprine, and 6-mercaptopurine, which have obvious toxic and side effects, and are only used in cases where the above-mentioned treatments are ineffective, and the curative effect is uncertain

[0004] The pathogenesis of the disease is emphasized in the active stage and the remission stage. In the active stage of the disease, there are mostly pathological changes in the intestines with damp heat, qi stagnation and blood stasis, and meat rot and blood stasis. Addition and subtraction of Shaoyao Decoction or Pulsatilla Decoction, commonly used Coptidis, Scutellaria, Phellodendron Phellodendron, Pulsatilla, Qinpi and other bitter and cold products, it is worth noting that excessive use of bitter cold not only hinders the health of the spleen and stomach, but also has the disadvantages of cooling and heat poison and reducing dryness and impairing yin

At the same time, the active stage of ulcerative colitis is mainly characterized by damp heat and blood stasis, and attention should be paid to the treatment of clearing the intestines to remove dampness, cooling blood and stopping bleeding. Currently, there is no compound drug with the best drug ratio in clinical practice, and it cannot be popularized and used.

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