37 results about "Refractory Disease" patented technology

The neutralizing antibody against HGF binding to the inventive neutralizable epitope of HGF is capable of neutralizing HGF as a single agent, and can be effectively used for preventing and treating intractable diseases and cancers that are caused by binding of HGF to its receptor Met.

The invention discloses a compound combined medicine for treating ulcerative colitis. The compound combined medicine is prepared from the following components in parts by weight: 2-9 parts of coptis chinensis, 6-15 parts of scutellaria baicalensis, 10-30 parts of patrinia, 6-20 parts of fried angelica sinensis, 5-20 parts of parched white peony roots, 5-15 parts of raw garden burnets, 5-20 parts of lithospermum, 5-15 parts of madders, 6-15 parts of radix angelicae, 3-12 parts of simmered elecampane and 2-6 parts of raw liquorice. The invention further discloses a preparation method and application of the ompound combined medicine. The invention provides an effective therapeutic medicine for treating the refractory diseases ulcerative colitis and is economical and practical and broad in clinical application prospect. The compound combined medicine is simple in preparation method, simple, fast, efficient and easy to operate, and prepared granules are convenient to carry and take.

The invention relates to a method for constructing a cell transplantation slice by using human umbilical cord mesenchymal stem cells (hUC-MSCs) and anthropogenic amniotic membrane. The method comprises the following steps: taking the freshly collected anthropogenic amniotic membrane and umbilical cord, separating chorion from the amniotic membrane, treating the separated amniotic membrane by normal saline, and then cryopreserving for later use; cutting the umbilical cord into small pieces, and tearing Wharton's jelly off; cutting the Wharton's jelly into pieces, putting the cut Wharton's jelly onto a sterile culture vessel, adding a culture solution into the sterile culture vessel, and putting the sterile culture vessel into an incubator for culturing to obtain primary generation hUC-MSCs; adding pancreatin into a culture medium of the primary generation hUC-MSCs, digesting, and continuously culturing in the incubator to obtain the hUC-MSCs; carrying out sterile hydration on the cryopreserved standby amniotic membrane, then flatly laying the amniotic membrane on an amniotic membrane carrier thimble, and then moving into the sterile culture vessel; inoculating the hUC-MSCs in the culture vessel, and then culturing in the incubator to obtain the cell transplantation slice with cell confluence reaching up to 80-90%. The cell transplantation slice prepared by the method is capable of carrying out damage repair at specific parts, so that the defects of using the hUC-MSCs or amniotic membrane alone for treatment are overcome; therefore, a new treatment strategy is provided for refractory diseases, and a new therapy approach is opened up for the clinical application of stem cells.

The invention discloses a drug for treating vitiligo, and the drug takes lithargite, sulfur, blister beetle, calomel, mercury, borneol, costustoot, cassia bark, dried alum, and the like as the raw materials and uses tea seed oil, white flour and edible white vinegar for matching to produce an ointment. The drug uses the traditional Chinese medicine with toxicity as an antidote for toxin for treating the vitiligo, and the cure rate is more than 95 percent, thereby creating a new miracle and a breakthrough in medical treatment for the vitiligo which is a stubborn skin refractory disease.

The invention relates to a Chinese herbal medicinal wine for treating difficult and complicated miscellaneous diseases, belonging to Chinese herbal medicine field, which comprises Wooly Datchmanspipe Herb, Common Clubmoss Herb, Garden Balsam Stem, Rhizoma Ligustici, lithospermum, Lucid Ganodenma powder, Obscured Homalomena Rhizome, crab bone, Rubus phoenicolosius M-axim, plaster, actinolite, Fortune's Drynaria Rhizome and Beautiful Sweetgum Fruit. The thirteen Chinese herbal medicine are together put into 50 degrees liquor; each 650 g Chinese herbal medicine is put into 4kg of 50 degrees liquor, which is soaked for 7-15 days; and the medicine wine is obtained. The Chinese herbal medicinal wine has the advantages of pure Chinese herbal medicinal wine, no poison and side effect, significant therapeutic effect, which comprises various drug to treat femoral head necrosis, whole body muscle and bone pain caused by rheumatoid, arteriosclerosis, muscle pulse varices, innominate inflammatory, sore ganglion pain, external wound infection, red swelling, mosquitoe bite, nerve ending inflammation, beriberi, hemorrhoids, dermatosis and other various refractory diseases.

Disclosed is a therapeutic agent for neuropathic pain having an excellent therapeutic effect on neuropathic pain which is a intractable disease. More specifically, disclosed are a therapeutic agent for neuropathic pain which comprises a peripheral benzodiazepine receptor antagonist (particularly PK 11195) as the active ingredient; a pharmaceutical composition for the treatment of neuropathic pain which comprises a peripheral benzodiazepine receptor antagonist as the active ingredient; a method for the treatment of neuropathic pain using a peripheral benzodiazepine receptor antagonist; and others.

The invention discloses a compound combination medicine for treating ulcerative colitis, which comprises the following components in parts by weight: 2-9 parts of Coptis rhizome, 6-15 parts of Scutellaria baicalensis, 10-30 parts of Patrinia, 6-30 parts of fried angelica 20 parts, 5-20 parts of fried white peony, 5-15 parts of raw Burnet, 5-20 parts of comfrey, 5-15 parts of madder, 6-15 parts of Angelica dahurica, 3-12 parts of simmering wood fragrance, 2-6 parts of raw licorice share. The invention also discloses the preparation method and application of the compound medicine. The present invention provides an effective therapeutic drug for the clinical treatment of ulcerative colitis, an intractable disease, and is economical and practical, and has broad clinical application prospects; its preparation method is simple, fast, efficient, easy to operate, and the prepared granules are portable and convenient. take.

The invention discloses a formula for preventing and treating digestive system diseases. The formula comprises the following 13 raw materials: specially-made processed semen crotonis, specially-made rhizoma paridis powder, radix aristolochiae yunnanensis, fructus amomi, radix et caulis opuntiae dillenii, radix clematidis, resina ferulae, rhizoma atractylodis macrocephalae, rhizoma coptidis, radix notoginseng, fructus amomi rotundus and poria cocos. By the formula, toxins in human bodies can be eliminated, bacterial infection is controlled, normal physiological functions of digestive systems, such as gastrointestinal functions, liver functions, endocrine functions and the like, can be maintained, nutrient balance can be regulated, common diseases of the digestive systems can be timely cured, and conversion from common diseases to refractory diseases is effectively controlled; and the formula can be prepared into different types of liquid medicines according to requirements, and is convenient to popularize, sources of used traditional Chinese medicinal materials are sufficient, the used traditional Chinese medicinal materials are easy to purchase, utilization rate of medicinal raw materials is high, and thus, the formula is favorable for popularization.

The present invention provides a therapeutic agent for a lower urinary tract disease such as cystitis, interstitial cystitis, prostatitis, benign prostatic hyperplasia etc., which are considered as refractory disease, and an agent for improving a lower urinary tract symptom associated with the lower urinary tract disease.

The present invention provides a therapeutic agent for neuropathic pain having an excellent treating effect on neuropathic pain, which is an intractable disorder. More specifically, the present invention provides a therapeutic agent for neuropathic pain and a pharmaceutical composition for treating neuropathic pain, comprising (1) a compound having an anti-progesterone activity (for example, fulvestrant (ICI182.780), fluocinolone acetonide, triamcinolone acetonide, etc.), (2) a compound having an estrogen activity (for example, 17β-estradiol), or (3) a mixture of a compound having an anti-progesterone activity and a compound having an estrogen activity (for example, 17β-estradiol and fulvestrant), as an active ingredient; a method for treating neuropathic pain using such a compound, and the like.

The invention provides a composition (H1 / rAdv) gene drug delivery system formed by encapsulating recombinant Adenovirus (rAdv) with a polycationic carrier (H1). The composition (H1 / rAdv) of the present invention can efficiently and targetedly deliver the gene medicine mediated by adenovirus, and is useful for the development of therapeutic, control or preventive genes for genetic diseases, tumors and various refractory diseases. Drug delivery carrier system.