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Topiroxostat tablet and preparation method thereof

A technology of topicastat and tablet is applied in the field of tablets for treating migraine, topicastat tablet and preparation thereof, can solve problems such as failure to provide preparations and the like, and achieves simple and feasible process route, stable quality, Method to choose reasonable effect

Active Publication Date: 2015-07-08
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In summary, the existing methods have certain limitations and fail to provide a preparation with good effect

Method used

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  • Topiroxostat tablet and preparation method thereof
  • Topiroxostat tablet and preparation method thereof
  • Topiroxostat tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023]

[0024] The preparation process is as follows:

[0025] a. Pulverizing the raw material drug topicastat, passing the topicastat, pregelatinized starch, microcrystalline cellulose, hydroxypropyl cellulose, and cross-linked carboxymethyl cellulose sodium through a 30-mesh sieve respectively, for subsequent use;

[0026] B, take by weighing the prescription amount of topinostat, pregelatinized starch, microcrystalline cellulose, hydroxypropyl cellulose, croscarmellose sodium, mix uniformly;

[0027] c. Use purified water as a wetting agent to make soft materials, granulate with a 24-mesh sieve, dry at 60°C±5°C until the moisture content is not more than 3.5%, and granulate with a 18-mesh sieve; add the prescribed amount of magnesium stearate, and mix well; Tablet;

[0028] d. Finished product inspection and packaging.

Embodiment 2

[0030]

[0031] The preparation method is as in Example 1.

Embodiment 3

[0033]

[0034] The preparation method is as in Example 1.

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PUM

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Abstract

The invention provides a topiroxostat tablet and a preparation method thereof, and belongs to the technical field of medicines. The topiroxostat tablet is mainly prepared from a main drug, filler, a disintegrating agent, an adhesive and a lubricant. Topiroxostat is a non-purine selective xanthine oxidase inhibitor, and is used for treating gout and hyperuricemia. The topiroxostat tablet is safe and effective, has the advantages of quick disintegration, good solubility, stable quality, high bioavailability and low cost, is convenient to take, and can be used for improving the compliance of patients.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a topicastat tablet and a preparation method thereof. The invention provides a topicastat tablet which is safe and effective, has the advantages of fast disintegration, good dissolution, stable quality, high bioavailability, low cost and convenient administration. , a patient-compliant, migraine-treating tablet. Background technique [0002] Topinostat, Chinese chemical name: 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile, the structural formula is as follows: [0003] [0004] Molecular formula: C 13 h 8 N 6 [0005] Molecular weight: 248.24. [0006] Topinostat tablets are imitation tablets of Fuji Pharmaceutical Co., Ltd., Japan. Its trade name: TOPILORIC Tablets, Japanese name: トピロリツワ, general name: Topiroxostat, ロキソスタット; specifications: 20mg, 40mg and 60mg, released in June 2013 Approved for marketing, this product is a non-purine selective xanthin...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/444A61K47/38A61P25/06A61P19/06
Inventor 王明刚陈阳生任莉孙桂玉刘晓霞翟翠云臧云龙
Owner CP PHARMA QINGDAO CO LTD
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