A kind of topicastat tablet and preparation method thereof
A technology of topicastat and tablets, applied in the field of topicastat tablets and their preparation, and tablets for treating migraine, can solve problems such as failure to provide preparations and the like, and achieve a simple and easy process route, stable quality, Method to choose reasonable effect
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Embodiment 1
[0023]
[0024] The preparation process is as follows:
[0025] a. Pulverizing the raw material drug topicastat, passing the topicastat, pregelatinized starch, microcrystalline cellulose, hydroxypropyl cellulose, and cross-linked carboxymethyl cellulose sodium through a 30-mesh sieve respectively, for subsequent use;
[0026] B, take by weighing the prescription amount of topinostat, pregelatinized starch, microcrystalline cellulose, hydroxypropyl cellulose, croscarmellose sodium, mix uniformly;
[0027] c. Use purified water as a wetting agent to make soft materials, granulate with a 24-mesh sieve, dry at 60°C±5°C until the moisture content is not more than 3.5%, and granulate with a 18-mesh sieve; add the prescribed amount of magnesium stearate, and mix well; Tablet;
[0028] d. Finished product inspection and packaging.
Embodiment 2
[0030]
[0031] The preparation method is as in Example 1.
Embodiment 3
[0033]
[0034] The preparation method is as in Example 1.
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