Preparation method of calcitriol
A technology for calcitriol and compounds, which is applied in the field of preparation of calcitriol as a raw material for compounds, can solve the problems that calcitriol is not suitable for separation, stereoisomers cannot be completely separated, and the separated product has many impurities, and achieves Separation and preparation save time, shorten the production cycle, and the effect of simple split method
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[0024] The main process involved in this embodiment is the same as in the summary of the invention, wherein the three specific processes of the separation and preparation of compound 3a, the separation and preparation of compound 4a and the separation and preparation of compound 5a are as follows:
[0025]
[0026] Add compound 2a and sodium bicarbonate to methanol in turn, stir and maintain the temperature at 30°C, and use thin-layer chromatography (thin-layer chromatography conditions: silica gel is GF254; developing solvent: ethyl acetate-cyclohexane 3:1; The color agent is 5% phosphomolybdic acid or ethanol) to detect the degree of progress of the reaction; after the reaction is substantially complete, the methanol is recovered under reduced pressure and extracted with ethyl acetate, after drying and concentrating, the medium-pressure liquid chromatography column is used, and the mobile phase is ethyl acetate : Cyclohexane 1: 20, the flow rate is 10ml / min for elution, th...
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