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Application of traditional Chinese medicine composition to preparation of anti-helicobacter pylori medicines

An anti-Helicobacter pylori technology and a composition are applied in the application field of traditional Chinese medicine compositions in the preparation of anti-Helicobacter pylori drugs, and can solve problems such as indigestion, destruction of flora in the digestive tract and the like

Inactive Publication Date: 2015-07-22
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most important factor affecting triple therapy is considered to be the resistance of Hp to antibacterial agents; another serious problem is that proton pump inhibitors can induce indigestion, and a large amount of antibacterial agents can lead to serious destruction of the intestinal flora

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Take 18g of Ginger Grass, 20g of Yijianqiu, 15g of Alihong, 12g of Umbrella Maple, 18g of Wild Palm, and 20g of Bitter Bark, add water to decoct 2 times, and the amount of water added for the first time is 10 times the weight of the medicinal material amount, decocted for 2 hours, the amount of water added for the second time was 8 times the weight of the medicinal materials, decocted for 1 hour, combined the decoction, concentrated, dried, and pulverized to obtain Chinese medicine composition granules. The concentration conditions were: 0.07MPa, 60-70 The relative density is 1.30 when it is concentrated under reduced pressure at 65°C. The spray-drying conditions are: the inlet air temperature is 120°C, the outlet air temperature is 80°C, the material temperature is 90°C, the atomization pressure is 0.4 MPa, and the spray speed is 10ml / s.

Embodiment 2

[0016] Embodiment 2: the pharmacological experiment of Chinese medicine composition

[0017] 1) Tested strains

[0018] The Helicobacter pylori (Hp) standard strain ATCC 43504 was purchased from the American Type Culture Collection (ATCC). 15 clinical strains of Hp were collected from patients who received gastroscopic examination in Department of Gastroenterology, Jiangsu Provincial People's Hospital, Laboratory Department of Jiangsu Provincial Hospital of Traditional Chinese Medicine, and Gastroscopy Department of Nanjing Children's Hospital; For patients with verrucous gastritis, firstly, the Hp-positive patients were confirmed by the rapid urease test, and then 1-2 pieces of gastric antrum mucosa were taken, minced, and inoculated in a mixture containing 8% horse serum, trimethoprim (trimethropin, TMP) 1.25 g / L, polymyxin (polymyxin) B2500U / L, vancomycin (vancomycin) 10mg / L Columbia selective agar medium, under micro-aerobic environment (5% O2, 10% CO2 and 85% N2) for 72...

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PUM

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Abstract

The invention provides a traditional Chinese medicine composition. An in-vitro activity experiment shows that the traditional Chinese medicine composition has very strong helicobacter pylori (HP) resisting activity; and the traditional Chinese medicine composition is prepared from 18 parts of twoflower micromeria, 20 parts of all grass of unispike kyllinga, 15 parts of chalky guinine fungus, 12 parts of roots or barks of shortpedicel heteropanax, 18 parts of roots of caudate two-seeded palm and 20 parts of barks of Indian quassiawood. The traditional Chinese medicine composition can be used for treating diseases including acute and chronic gastritis, gastric ulcer and duodenal ulcer and the like, can be applied to medicines for treating the acute and chronic gastritis, the gastric ulcer and the duodenal ulcer, and has remarkable advancement.

Description

technical field [0001] The invention relates to a new application of the traditional Chinese medicine composition, in particular to the application of the traditional Chinese medicine composition in the preparation of anti-helicobacter pylori medicine. Background technique [0002] Helicobacter pylori (Hp) is a Gram-negative spiral bacterium. Studies have shown that Helicobacter pylori is the main cause of acute and chronic gastritis and gastric and duodenal ulcers, and may be related to gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) malignant lymphoma. Recently, the World Health Organization classified Hp as a class I carcinogen, which plays a leading role in the development of gastric cancer. The current popular treatment for Hp infection is the triple therapy of taking proton pump inhibitor (PPI) plus two kinds of antibiotics (clarithromycin, amoxicillin, tetracycline, metronidazole, etc.) at the same time. The most important factor affecting triple...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/89A61P31/04
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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