Hemostasis dressing and preparation method thereof

A technology of hemostatic dressing and pharmaceutical excipients, which is applied in the field of medicine, can solve the problems of injury bleeding, inconvenient use of zeolite drugs, etc., and achieve the effect of increasing the concentration, accelerating the blood coagulation reaction speed, and accelerating the blood coagulation process

Inactive Publication Date: 2015-07-22
ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the inconvenient use of powdered zeolite drugs in the prior art outdoors, the present invention provides a hemostatic dressing and a preparation method thereof. The hemostatic dressing can quickly absorb moisture in the blood, promote blood coagulation, and have superior hemostatic effects. The most important thing is its It can solve the problem of inconvenient use of powdered zeolite drugs outdoors. It can not only be used for superficial tissue injury and bleeding, but also can be applied to the situation of heavy bleeding caused by severe trauma.

Method used

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  • Hemostasis dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Zeolite: particle size 0.1mm~0.2mm, 0.95g

[0036] Pharmaceutical excipients: Povidone (PVP) K30, 0.05g

[0037] (1) Pulverizing the zeolite, passing through a 100-mesh sieve, and passing through a 100-mesh sieve for pharmaceutical excipients;

[0038] (2) Drying the sieved zeolite and pharmaceutical excipients at 150° C. for 2 hours, respectively, to dry and sterilize;

[0039] (3) Mix the sterilized zeolite and pharmaceutical excipients uniformly, and seal and store.

[0040] Take 1g of the hemostatic dressing and add water to observe the water absorption. When the saturated water absorption is reached, the total water absorption is 0.45ml, and the zeolite and PVP K30 can be well mixed and formed.

[0041] Subsequent coagulation time measurement was carried out on the hemostatic dressing, and the coagulation time was 136s.

Embodiment 2

[0043] Zeolite: particle size 0.1mm~0.2mm, 0.9g

[0044] Pharmaceutical excipients: PVP K30, 0.1g

[0045] (1) Pulverizing the zeolite, passing through a 100-mesh sieve, and passing through a 100-mesh sieve for pharmaceutical excipients;

[0046] (2) Drying the sieved zeolite and pharmaceutical excipients at 150° C. for 2 hours, respectively, to dry and sterilize;

[0047] (3) Mix the sterilized zeolite and pharmaceutical excipients uniformly, and seal and store.

[0048] Take 1g of the hemostatic dressing and add water to observe the water absorption. When the saturated water absorption is reached, the total water absorption is 0.45ml, and the zeolite and PVP K30 can be well mixed and formed.

[0049] The coagulation time of the hemostatic dressing was subsequently measured, and the coagulation time was 109s.

Embodiment 3

[0051] Zeolite: particle size 0.1mm~0.2mm, 0.8g

[0052] Pharmaceutical excipients: PVP K30, 0.2 g

[0053] (1) Pulverizing the zeolite, passing through a 100-mesh sieve, and passing through a 100-mesh sieve for pharmaceutical excipients;

[0054] (2) Drying the sieved zeolite and pharmaceutical excipients at 150° C. for 2 hours, respectively, to dry and sterilize;

[0055] (3) Mix the sterilized zeolite and pharmaceutical excipients uniformly, and seal and store.

[0056] Take 1g of the hemostatic dressing and add water to observe the water absorption. When the saturated water absorption is reached, the total water absorption is 0.35ml, and the zeolite and PVP K30 can be well mixed and formed.

[0057] The coagulation time of the hemostatic dressing was subsequently measured, and the coagulation time was 87s.

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Abstract

The invention discloses a hemostasis dressing which comprises zeolite and a medicinal auxiliary material, wherein the ratio of zeolite to the medicinal auxiliary material is (1-20):1; the particle size of zeolite is 0.1-0.6 mm; the medicinal auxiliary material is at least one of povidone K30, povidone K90, starch, dextrin, polyethylene glycol, pregelatinized starch, arabic gum, carbomer 974P and sodium alginate. The medicinal auxiliary material used in the hemostasis dressing is relatively good in water absorbing function and can cooperate with zeolite for stop bleeding, and gel can be generated after the auxiliary material absorbs water and can be adhered to zeolite powder, so that a protecting layer can be formed on a wound surface; the auxiliary material can be absorbed by a user, and healing of wound can be promoted.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a hemostatic dressing and a preparation method thereof. Background technique [0002] From the era of cold weapons to the present, the hemorrhage that cannot be effectively controlled is the main cause of death of the wounded and patients. Usually, the general principles for the treatment of bleeding wounded are simple first aid, rapid evacuation, and surgical treatment. With the development and progress of medicine, the relative backwardness of pre-hospital first aid has become a bottleneck in the treatment of bleeding wounded in today's highly mature surgical technology. [0003] Traditional hemostatic measures not only have uncertain hemostatic effect, but also have the risk of serious complications. After the end of the Cold War, great changes have taken place in the scale of war. The level of scientific and technological achievements in the battlefield is getting higher a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/44
Inventor 高建青李平阮桂鑫王霞蓉
Owner ZHEJIANG UNIV
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