Application of ebony plum and its extract in the preparation of medicines or health care products for preventing and treating intestinal cancer

A technology of extract and ebony, which is applied in the field of medicine to achieve the effects of convenient administration, reliable curative effect and safe use

Active Publication Date: 2018-01-05
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the drugs used for the treatment of CRC mainly include oxaliplatin, fluorouracil, irinotecan, folic acid and bevacizumab, etc. However, the five-year survival rate after radical resection of CRC is still hovering around 50%, and it is even less than 30% in the advanced stage. %
However, there is no relevant report on the use of ebony extract in the preparation of drugs for the prevention and treatment of intestinal disease carcinogenesis.

Method used

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  • Application of ebony plum and its extract in the preparation of medicines or health care products for preventing and treating intestinal cancer
  • Application of ebony plum and its extract in the preparation of medicines or health care products for preventing and treating intestinal cancer
  • Application of ebony plum and its extract in the preparation of medicines or health care products for preventing and treating intestinal cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation method of the ebony extract: take the dried ebony medicinal material, add water and steam for 2-3 times, each time for 1-3 hours. Add 5-15 times the amount of water for the first time, filter, add 5-15 times the amount of water for the second time, filter, add 5-10 times the amount of water for the third time, and filter. The three filtrates were combined, centrifuged (3000rpm) for 15 minutes, and the supernatant was separated, and the concentration was adjusted to 1 g medicinal material / ml in a water bath at 60 ° C, or dried under reduced pressure to form a dry extract.

Embodiment 2

[0024] Example 2 Study on the preventive and therapeutic effects of ebony extract on AOM-DSS-induced mouse colon tumors.

[0025] 1. Experimental materials

[0026] 1.1 Experimental drugs and reagents

[0027] Black plum extract: the black plum extract prepared in Example 1 of the present invention; azoxymethane (AOM) was purchased from sigma company, batch number: SLBD6763V; dextran sodium sulfate (dextran sodium sulfate, DSS) was purchased from Mpbio company , batch number: M8667.

[0028] 1.2 Experimental animals and breeding

[0029] C57 mice, 18-22g, male, provided by the Comparative Medicine Center of Yangzhou University, certificate number: SCXK (Su) 2012-0004. Full-price nutritional pellet feed: provided by Jiangsu Synergy Pharmaceutical Biotechnology Co., Ltd. Breeding conditions: room temperature 20±2°C, humidity 55–65%, alternating light and dark, moderate light, good ventilation and cleanliness.

[0030] 2. Method

[0031] 2.1 AOM-DSS-induced inflammatory bow...

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Abstract

The invention discloses the new application of ebony and its extracts in the prevention and treatment of intestinal cancer. Based on the existing efficacy of ebony, the present invention conducts in-depth research through a large number of experiments, and adopts a mouse model of enteropathy induced by AOM-DSS to study The results show that ebony and its extracts can significantly improve the weight loss of model mice in the process of enteropathy carcinogenesis, significantly improve the progressive weight loss, loose stools and bloody stools and other symptoms of enteropathy carcinogenesis mice; The incidence of colon tumors in mice has a good effect on preventing and controlling colon cancer.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to the new application of ebony plum and its extract in the preparation of medicines for preventing and treating intestinal cancer, and belongs to the technical field of medicine. Background technique [0002] Colorectal cancer (CRC), also known as colorectal cancer, is one of the most common malignant tumors. More than one million people worldwide suffer from colorectal cancer every year and cause about 50 million deaths, accounting for the largest proportion of malignant tumors in the world. Death ranks fourth. At present, the incidence of colorectal cancer in my country is on the rise, and the domestic incidence rate is about 4.8%, far exceeding the international level of 2%. [0003] At present, the drugs used for the treatment of CRC mainly include oxaliplatin, fluorouracil, irinotecan, folic acid and bevacizumab, etc. However, the five-year survival rate after radical resection...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A23L33/105A61P35/00A23L33/00
Inventor 陈玉根王琼杨柏霖曹园朱敏周锦勇朱萱萱
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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