A kind of medicine for treating Parkinson's disease, preparation method and preparation

A Parkinson's disease and drug technology, applied in the field of traditional Chinese medicine, can solve the problems of dyskinesia and mental symptoms, end-of-dose phenomenon, switching phenomenon, etc., and achieve the effects of small side effects, fast onset and easy operation.

Inactive Publication Date: 2018-06-01
贵州中医药大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, levodopa and its compound preparations are mostly used clinically for treatment, but after long-term use, adverse reactions such as diminished curative effect, on-off phenomenon, end-of-dose phenomenon, dyskinesia and psychiatric symptoms may occur

Method used

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  • A kind of medicine for treating Parkinson's disease, preparation method and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Table 1 The amount of each component in Example 1 / g

[0038] Eleuthero

rhodiola

Knotweed

Vinegar tortoise shell

antler glue

cistanche

Antelope horn

ice flakes

9

10

12

8

1

8

0.1

0.001

[0039] The preparation method comprises the following steps:

[0040] Add vinegar and tortoise shells to boil with high heat and keep boiling for 1 hour, then add Polygonum cuspidatum, Acanthopanax, Rhodiola rosea, and Cistanche and continue to cook for 2 hours. After decocting, filter, collect the filtrate and medicinal residues; take the medicinal residues and add water to decoct for 1.5 hours before filtering, and combine the collected filtrate with the filtrate collected by the first filtration. Heat the above combined filtrate to 60°C, put in ground antler gum, stir continuously for melting, and after all dissolve, a thick paste is obtained; then add crushed antelope horn and borneol powder and mix well to ...

Embodiment 2

[0042] Table 2 The amount of each component in Example 2 / g

[0043] Eleuthero

rhodiola

Knotweed

Vinegar tortoise shell

antler glue

cistanche

Antelope horn

ice flakes

15

12

15

10

3

10

0.4

0.0013

[0044] The preparation method comprises the following steps:

[0045] Add vinegar and tortoise shells to boil with high heat and keep boiling for 1 hour, then add Polygonum cuspidatum, Acanthopanax, Rhodiola rosea, and Cistanche and continue to cook for 2 hours. After decocting, filter, collect the filtrate and medicinal residues; take the medicinal residues and add water to decoct for 1.5 hours before filtering, and combine the collected filtrate with the filtrate collected by the first filtration. Heat the above combined filtrate to 65°C, put in the chopped antler gum, stir continuously for melting, and then make a thick paste after all of it dissolves; then add crushed antelope horn and borneol powder and...

Embodiment 3

[0047] Table 3 The amount of each component in Example 3 / g

[0048] Eleuthero

rhodiola

Knotweed

Vinegar tortoise shell

antler glue

cistanche

Antelope horn

ice flakes

27

15

12

13

5

12

1

0.002

[0049] The preparation method comprises the following steps:

[0050]Add vinegar and tortoise shells to boil with high heat and keep boiling for 1.5 hours, then add Polygonum cuspidatum, Acanthopanax, Rhodiola rosea, and Cistanche and continue to cook for 2.5 hours. . Filter after decocting, collect the filtrate and medicinal residues; take the medicinal residues and add water to decoct for 2 hours before filtering, and combine the collected filtrate with the filtrate collected by the first filtration. Heat the above combined filtrate to 70°C, put in chopped antler gum, stir continuously for melting, and then make a thick paste after all of it dissolves; then add crushed antelope horn and borneol powder and mi...

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Abstract

The invention provides a drug for preventing Parkinson's disease, which is characterized in that, in parts by weight, it comprises the following components: 9-27 parts of Acanthopanax, 10-15 parts of Rhodiola, 12-18 parts of Polygonum cuspidatum, vinegar 8-13 parts of tortoise shell, 1-5 parts of antler gum, 8-12 parts of cistanche, 0.1-1 part of antelope horn and 0.001-0.002 part of borneol. The formula is scientific and exquisite. According to the theory of monarch, subject and assistant in traditional Chinese medicine, each component is scientifically compatible, and can play a multi-target role in the pretreatment of Parkinson's disease. B-type monoamine oxidase (MAO‑B), increase the content of DA in the striatum, etc., so as to achieve the effect of preventing Parkinson's disease.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a medicine for preventing Parkinson's disease, a preparation method and a preparation. Background technique [0002] Parkinson's disease (PD) is a common neurodegenerative disease among middle-aged and elderly people, and it is also the most common extrapyramidal system disease among middle-aged and elderly people. The prevalence rate of people over 65 years old is 1000 / 100,000. With increasing age, the incidence rate of men is slightly higher than that of women. The main clinical features of the disease: resting tremor, slowness and decrease in movement, increased muscle tone, and unstable posture are the main features. [0003] At present, there is no clear and curable method or drug for the treatment of Parkinson's disease. At present, levodopa and its compound preparations are mostly used clinically for treatment, but after long-term use, adverse reactions such ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/704A61P25/16A61K35/586A61K35/32A61K31/045
Inventor 吴远华
Owner 贵州中医药大学
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