Traditional Chinese medicine composition capable of resisting thyroid cancer activity and preparation method and application thereof

A thyroid cancer and composition technology, which is applied in the field of traditional Chinese medicine composition with anti-thyroid cancer activity and its preparation, can solve the problems of large dosage, many impurity components, and slow onset of action, and achieve less dosage and scientific proportioning Reasonable and fast absorption effect

Active Publication Date: 2015-08-19
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

However, the current reported antithyroid cancer drugs have

Method used

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  • Traditional Chinese medicine composition capable of resisting thyroid cancer activity and preparation method and application thereof
  • Traditional Chinese medicine composition capable of resisting thyroid cancer activity and preparation method and application thereof
  • Traditional Chinese medicine composition capable of resisting thyroid cancer activity and preparation method and application thereof

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preparation example Construction

[0036] The preparation method of the Chinese medicine composition with antithyroid cancer activity of the present invention, it comprises the following steps:

[0037] (1) Take 12 grams of North Radix Ginseng, 10 grams of Ophiopogon japonicus, 15 grams of Prunella vulgaris Prunella, 15 grams of Shanzi mushroom, and 10 grams of August Zha in parts by weight, add 15 times the volume of water of the total medicinal material weight, and soak 48 hours, then decocted and extracted 3 times, 2 hours each time, combined the extracts, concentrated, the concentrate was sequentially extracted with petroleum ether, chloroform, ethyl acetate, n-butanol, and the ethyl acetate and n-butanol extracts, the concentration dried extract;

[0038] (2) Take black nightshade in parts by weight, add acid water to soak for 24 hours, then decoct and extract 3 times, each time for 3 hours, then add alkaline water to adjust the pH value to 12, extract with chloroform to obtain chloroform extract, concentr...

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Abstract

The invention discloses a traditional Chinese medicine composition capable of resisting thyroid cancer activity and a preparation method and an application thereof. The traditional Chinese medicine composition is prepared by 20 to 60 parts of black nightshade herb, 12 to 36 parts of radix glehniae, 10 to 30 parts of radix ophiopogonis, 15 to 45 parts of ajuga decumbens thunb, 15 to 45 parts of edible tulip, and 10 to 30 parts of fiveleaf akebia fruit. After proofing by pharmacological experiments, the traditional Chinese medicine composition capable of resisting the thyroid cancer activity has the advantages that the proportion is scientific and reasonable, the usage of the medicine is strict, and the effects of resisting cancers and detoxifying, dissipating phlegm and removing blood stasis, benefiting qi and nourishing yin and the like are realized; the strong killing function on the cells of thyroid cancer inside and outside the human body is realized, the generation of tumor necrosis factors is promoted, and the immunity of a tumor patient is improved; the safety is high, and the toxic and side effect is low. The preparation method has the advantages that the quality is stable, the content of extracted effective ingredients is high, the operability is high, and the preparation method is suitable for industrial and large-batch production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine composition with antithyroid cancer activity and its preparation method and application. Background technique [0002] Thyroid carcinoma (thyroid carcinoma) is the most common malignant tumor of the thyroid gland. It is a malignant tumor derived from thyroid epithelial cells. Follicular adenocarcinoma (20%), but the prognosis is better, the tumor of follicular adenocarcinoma grows faster, is moderately malignant, easy to transfer through blood supply, undifferentiated carcinoma has a poor prognosis, and the average survival time is 3 to 6 months moon. Among thyroid cancers, papillary carcinoma is more common clinically. Clinically, the current drugs for the treatment of thyroid cancer are mainly chemical drugs. However, due to the high toxicity of chemotherapy drugs, they can not only kill tumor cells, but also non-selectively kill the body's own ...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P35/00
Inventor 程海波周仲瑛沈卫星李柳孙东东徐长亮谭佳妮沈政洁吴东东
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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