A kind of method of cleaning ultrafiltration membrane package

Abstract

The present invention provides a method for cleaning an ultrafiltration membrane bag, and belongs to the field of filter membrane cleaning methods. Hot alkali salt mixed solution is use d for cycling washing of the ultrafiltration membrane bag; PBS buffer is used for washing balance; by controlling the pressure in the operation, the integrity of membrane bag is ensured in the operation, so as to achieve the purpose of impurity removal from the membrane bag. The method of the invention is simple and easy to control; the used solutions are commonly used in vaccine production process, do not increase the risk of product quality and safety; the method can effectively remove impurities in ultrafiltration membrane bag, increase the average water flow, reduce the risks of membrane penetration and membrane leakage in the dialysis and concentration processes, and effectively prevent product loss, environmental pollution and operator hazardous incidents due to leakage; and the method can be widely used in the field of preparation of vaccines, improves production efficiency, reduce production costs, and achieve good economic value.

Description

technical field [0001] The invention relates to a method for cleaning an ultrafiltration membrane bag. Background technique [0002] Ultrafiltration is a kind of membrane separation technology. It is a process driven by pressure difference. Its separation mechanism is to rely on stable pressure and flow rate to achieve sieving through the membrane aperture, and to separate at the molecular level, forcing small molecular components to are filtered out and macromolecules are retained. Since ultrafiltration can be completed at room temperature without adding other substances, the membrane separation system is composed of membrane modules with different retention characteristics to separate, concentrate, and purify the active ingredients, so ultrafiltration membranes are widely used in environmental protection, food, and medicine. and other fields. [0003] At present, in the production of biological products, ultrafiltration has shown significant technical advantages. The ul...

AI Technical Summary

Problems solved by technology

The filter membrane is a special polymer structure. Due to the high frequency of cleaning, regeneration, and repeated use during use, membrane pore blockage, membrane penetration, membrane leakage, and membrane bag pollution will occur, which may easily lead to bacterial toxicity or biological activity. Leakage of ingredients, resulting in loss of antigens or environmental contamination

At present, the integrity detection of filter membrane fibers mostly depends on the detection method of the ultrafiltration membrane bag manufacturer. The ultrafiltration membrane bag is cleaned and regenerated after repeated use. The manufacturer recommends that the membrane bag can still be used after the membrane integrity tester is used to detect the integrity of the membrane bag. , and in actual application, the ultrafiltration membrane bag is cleaned and regenerated after repeated use, and then treated with the cleaning method and testing procedure given by the manufacturer, and the qualified membrane bag is tested again. In addition, it is cumbersome to use instruments to detect the integrity of the membrane package, and the membrane package needs to be disassembled repeatedly. This method is not suitable for the field of biological product preparation that requires continuous production.

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