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Natural medicine composition used for treating cardiovascular diseases

A technology of natural medicine and composition, which is applied in the field of natural medicine composition composition ratio and natural medicine composition, which has the effect of treating cardiovascular diseases, can solve the problems of strong toxicity and easy arrhythmia, and achieve good and strong side effects Cardiac effect, synergistic effect

Active Publication Date: 2015-09-02
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Aconitine is one of the active ingredients in aconite, which has positive inotropic effect, but its toxicity is very strong, it is easy to cause arrhythmia, and it is difficult to be used alone in clinical practice
[0004] At present, there is no literature report on a pharmaceutical composition that can fully exert the efficacy of the classic famous prescription "Sini Decoction" and reduce its toxic and side effects

Method used

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  • Natural medicine composition used for treating cardiovascular diseases
  • Natural medicine composition used for treating cardiovascular diseases
  • Natural medicine composition used for treating cardiovascular diseases

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of natural medicinal composition

[0017] Dissolve 1 mg of aconitine, 10 mg of 6-gingerol and 100 mg of liquiritin in an appropriate amount of water, and obtain the natural medicine composition of the present invention after completely dissolving.

Embodiment 2

[0018] Embodiment 2: the preparation of natural medicinal composition

[0019] Take 2 mg of aconitine, 5 mg of 6-gingerol, and 150 mg of liquiritin and dissolve them in an appropriate amount of water, and after completely dissolving, the natural medicine composition of the present invention is obtained.

Embodiment 3

[0020] Embodiment 3: Effect test of natural medicine composition on heart failure model rats

[0021] 1. Experimental method

[0022] 1.1 Animals

[0023] 50 SD rats (purchased from the Animal Center of the Second Military Medical University of the Chinese People's Liberation Army), male, weighing 180-200 g.

[0024] 1.2 Animal modeling

[0025] The rats were weighed, anesthetized with ether, and the surgical area was disinfected with iodine after skin preparation, and a towel was spread. The skin and pectoralis major muscle were incised sequentially along the third and fourth intercostal spaces to expose the ribs. The pleura was opened to expose the heart, and the left anterior descending coronary artery (LAD) was ligated 1 mm below the edge of the left atrial appendage and the conus pulmonary artery. The 3rd and 4th ribs, muscle layer and skin were sutured sequentially. In the sham operation group, the thread was not ligated. Intraperitoneal injection of penicillin 8 m...

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Abstract

The invention relates to a natural medicine composition used for treating cardiovascular diseases. The natural medicine composition comprises aconitine, liquiritin and 6-gingerol and is prepared into oral preparations, such as hard capsules, soft capsules, tablets, granules, powder, pills, tea bags and medicinal liquor by utilizing synergistic effects of the components. The composition can achieve the effects of treating rats with heart failures caused by myocardial infarction, increasing the ejection fractions and fractional shortening of the rats, obviously improving cardiomyocyte morphologies, reducing the degree of cardiac collagen fibrosis and reducing the contents of aldosterone and atrial natriuretic peptide in serums, and has the function of treating cardiovascular diseases. The composition has definite pharmacodynamic effects, is rigorous in quality control and small in taking dosage and is convenient to take.

Description

Technical field: [0001] The invention relates to a natural medicinal composition for treating cardiovascular diseases, in particular to a composition ratio of natural medicinal compositions capable of treating cardiovascular diseases, and belongs to the field of medicine and pharmacy. Background technique: [0002] Cardiovascular disease is increasing day by day, and its condition is serious, ranking first in the cause of death of patients due to disease in the world. For the tens of millions of cardiovascular disease patients worldwide, especially those at high risk of cardiovascular disease, how to reduce the morbidity and mortality of cardiovascular disease through effective intervention has become an increasingly urgent major public health problem . With the economic development of our country in recent years, the average life expectancy has been extended, cardiovascular diseases have increased, and the demand for cardiovascular drugs is increasing. Therefore, the devel...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/00A61P9/04A61K31/439A61K31/12
Inventor 张国庆张海李盛建张雯柴逸峰
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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