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Application of flavonoids compound baicalein in skin cicatrisation inhibition

A technology of baicalein and skin, applied in the application field of flavonoid baicalein in inhibiting skin scar formation, achieving the effect of good transdermal absorption capacity, high fat solubility and small molecular weight

Inactive Publication Date: 2015-09-23
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the role of baicalein in inhibiting skin scarring

Method used

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  • Application of flavonoids compound baicalein in skin cicatrisation inhibition
  • Application of flavonoids compound baicalein in skin cicatrisation inhibition
  • Application of flavonoids compound baicalein in skin cicatrisation inhibition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. Experimental materials and methods

[0039] 1. Physicochemical properties of baicalein molecules

[0040] The baicalein (CAS 491-67-8) molecule used in the experiment was purchased from Selleck (cat.no.S2268).

[0041] Drug penetration through the stratum corneum and epidermis into the dermis is the main route for drug absorption through the skin. To achieve transdermal absorption of drugs, the following requirements need to be met: the dosage is small and the effect is strong; substances with a molecular weight greater than 600 are difficult to pass through the stratum corneum; organic weak acids or organic weak bases exist in molecular form and have greater transdermal penetration. Fat-soluble drugs have an ideal transdermal absorption effect, while ionic drugs are generally difficult to penetrate the stratum corneum. The molecular weight of baicalein is 270.24, and the molecular formula is as follows figure 1 , belongs to organic weakly acidic drugs, and has good...

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Abstract

The invention relates to the application of flavonoids compound baicalein in skin cicatrisation inhibition. The invention verifies the fact that baicalein can be combined with TGFbetaRI(ALK5) to inhibit a TGFbeta1 signal channel in a cell, and accordingly abnormal proliferation, activation, shrinking and migration ability of human cicatrisation fibroblast are inhibited. An animal in-vivo experiment verifies the fact that after baicalein has an effect on mouse skin, mouse skin cicatrisation induced by tension can be inhibited. Baicalein is small in molecular weight and high in fat solubility, transdermal absorption capacity is good, accordingly, the molecules can be used for preparing medicine for skin cicatrisation inhibition, and the baicalein has wide application prospect in the field of medical treatment, plastic surgery and cosmetics.

Description

technical field [0001] The invention relates to a new medical application of the flavonoid compound baicalein, in particular to the application of the flavonoid compound baicalein in inhibiting skin scar formation. Background technique [0002] Scarring is one of the most common complications after wound healing. Scar formation affects the appearance of the patient, accompanied by itching and pain, and the resulting contracture can lead to different degrees of dysfunction, such as tendon contracture, joint dislocation, motor dysfunction, occupational psychological disorder, etc., which reduces the quality of life of the patient. Later treatment brings heavy economic and psychological burden. According to statistics, the incidence of hypertrophic scars after burns among Chinese people is 91.4%. If the burn wound healing time exceeds 2 weeks, the incidence of hypertrophic scars is as high as 74.67%, which is much higher than the 38.00% reported abroad. The prevention and tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P17/02
Inventor 张艺凡李青峰汪景单圣周
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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