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Treatment of thalamocortical dysrhythmia

An abnormal rhythm, thalamocortical technology, applied in diseases related to thalamocortical abnormal rhythm, to treat patients with abnormal thalamocortical rhythm disorders, can solve the problem that ketamine does not provide sustained relief such as suicide or depression

Inactive Publication Date: 2015-10-14
斯蒂文·理查德·德沃尔·贝斯特
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, ketamine does not appear to provide sustained relief from suicide or depression

Method used

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  • Treatment of thalamocortical dysrhythmia
  • Treatment of thalamocortical dysrhythmia
  • Treatment of thalamocortical dysrhythmia

Examples

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Effect test

example 1

[0048] Example 1: TMS / Ketamine Therapy

[0049] Thirty-five patients were treated with ketamine combined with TMS. All 28 patients who completed the treatment shown in Table 1 had a positive effect after completing the treatment regimen shown in Table 2 (Table 1 and Table 2 are located at the end of the description before the claims). To simplify the presentation in Table 2, patients who received more than one treatment per week were indicated as having received one treatment in that week. Likewise, intervals are rounded to the nearest week.

[0050] Some patients received a pretreatment (PT) of 3 days to two weeks (usually 6 or 7 days) with daily TMS treatment (generally indicated as "PT days" or "PT weeks" in Figure 2). Others received pre-TMS therapy before combination therapy. Although most patients received pretreatment or pretreatment, some patients received neither pretreatment nor pretreatment. Since pretreatment was more lenient than pretreatment of several days, ...

example 2

[0052] Example 2: TLVES / Ketamine Therapy

[0053] Three patients were initially treated with TMS / ketamine as described above and improved significantly. However, these patients are more vulnerable and less robust than other members of the group.

[0054] Patients were treated with tACS or tRNS by defining the anode at F3 and cathode at F8 relative to the net current. Electrical stimulation of the electrodes was applied for about 20 minutes. Ketamine was started after 5 minutes and a total of 0.5 mg / kg to 5.0 mg / kg was continuously infused for 15-50 minutes. For tACS, the parameter is 1200 uA (no offset) or 1200 uA (1000 uA offset). For tRNS, the parameter is 1300 microampere or 2000 microampere (offset of 1000 microampere). Thanks to the use of TLVES / ketamine, all three patients have been able to achieve the same therapeutic effect as TMS / ketamine with less post-treatment fatigue.

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Abstract

A method for treating conditions associated with thalamocortical dysrhythmia. The method includes applying transcranial low voltage electrical stimulation (TLVES) therapy or transcranial magnetic stimulation (TMS) therapy to a patient in need thereof, and administering to the patient a dissociative anesthetic during the TLVES therapy or the TMS therapy. A number of conditions including tinnitus, depression and pain can be treated with TLVES or TMS in combination with the dissociative anesthetic, such as an NMADR inhibitor, including ketamine.

Description

[0001] Cross references to related patent applications [0002] This patent application claims the benefit of U.S. Patent Application Serial No. 13 / 826,250, filed March 14, 2013, and U.S. Provisional Patent Application Serial No. 61 / 729,625, filed November 25, 2012, both of which are incorporated by reference The method is incorporated in this article in its entirety. Background technique [0003] Millions of people worldwide suffer from neurological disorders. Many of these different psychiatric disorders are associated with abnormal thalamocortical rhythms, which are generally identified by a spectrum of neurological and psychiatric disorders arising from abnormal oscillatory activity of the major neural circuits connecting the thalamus and cortex of the brain. Symptoms vary depending on where in the brain the rhythm disruption occurs, but the neuronal mechanism is the same. Abnormal rhythms interfere with normal communication in and between different areas of the brain, t...

Claims

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Application Information

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IPC IPC(8): A61M19/00A61N2/00A61N1/36
CPCA61N2/002A61M15/00A61M19/00A61M21/00A61M2021/0055A61M2202/048A61N1/36021A61N1/36025A61N2/006A61N2/008A61N2/02A61K45/06A61K31/135F04C2270/0421A61P25/00A61P25/02A61P25/04A61P25/16A61P25/18A61P25/24A61P25/30A61P27/16A61P43/00A61K31/42A61K31/485A61K2300/00A61P29/00
Inventor 斯蒂文·理查德·德沃尔·贝斯特
Owner 斯蒂文·理查德·德沃尔·贝斯特
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