Method for prediction of cancer patient prognosis state by detection of three-stage colon and rectum cancer patient serum

A technology for colorectal tumors and patients, applied in anti-tumor drugs, biological testing, measuring devices, etc., can solve problems such as no one doing research

Active Publication Date: 2015-11-04
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although some people have used this method to test in patient serum, and some cytokines related to prognosis have been obtained, but no one has conducted research on patients with stage III colorectal cancer. We are the first

Method used

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  • Method for prediction of cancer patient prognosis state by detection of three-stage colon and rectum cancer patient serum
  • Method for prediction of cancer patient prognosis state by detection of three-stage colon and rectum cancer patient serum
  • Method for prediction of cancer patient prognosis state by detection of three-stage colon and rectum cancer patient serum

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] experiment method

[0025] patient:

[0026] From 2010 to 2012, the serum of 357 patients with stage III colorectal cancer undergoing surgical treatment in the Department of Colorectal and Anal Diseases Surgery of Xinhua Hospital was continuously collected. Among these 357 patients, 323 patients had complete 2-year DFS follow-up data.

[0027] method

[0028] The 45-factor Luminex200 kit from Ebioscience was used to detect the concentration of 45 cytokines in the patient's blood, and the cutoff value of each cytokine was determined according to the ROC curve, and then the patients were divided into high-expression group and low-expression group according to the cutoff value. Then, the graphpad software was used to analyze the survival difference between the two groups, so as to judge the influence of different cytokines on the prognosis of patients.

[0029] result:

[0030] Using single factor cox regression analysis, it was found that IFN-r, IL-8, IL-10, VEGFA, MIP...

Embodiment 2

[0037] A reagent, kit or detection method, etc. for detecting the levels of RNATES, MIP-1b or IFN-g in the patient's serum to predict the prognosis of patients with stage III colorectal cancer.

[0038] In particular, the reagent, kit or detection method simultaneously detects the levels of RNATES, MIP-1b and IFN-g.

Embodiment 3

[0040] Drugs that can increase the serum levels of RNATES and MIP-1b in patients with colorectal tumors or reduce the levels of IFN-g in the serum of patients with colorectal tumors may be able to improve the survival rate of patients with stage III colorectal tumors, and even treat colorectal tumors.

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Abstract

The invention relates to a novel purpose of RNATES, MIP-1b and IFN-g and discloses a method for prediction of a cancer patient prognosis state by detection of RNATES, MIP-1b and IFN-g levels of three-stage colon and rectum cancer patient serum. The method creatively proves that through detection of RNATES, MIP-1b and IFN-g levels of patient serum, a prognosis state of a three-stage colon and rectum cancer patient can be predicted.

Description

technical field [0001] The invention relates to the technical field of colorectal cancer, specifically, predicting the prognosis of tumor patients by detecting the levels of RNATES, MIP-1b and IFN-g in the serum of patients with three-stage colorectal tumors. Background technique [0002] Colorectal tumor is one of the common malignant tumors, with a high incidence rate in both men and women, and it ranks fourth in the global cancer death cases. At present, patients with stage III bowel cancer refer to patients with lymph node metastasis when they are first diagnosed. For patients with stage III bowel cancer, surgical resection and adjuvant radiotherapy and chemotherapy are the standard treatment options. However, there are still a quarter of patients with stage III bowel cancer After the patient received standard treatment, recurrence and distant metastasis still occurred. [0003] There are many factors that affect the prognosis of bowel cancer patients, and many studies ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68A61K45/00A61P35/00
CPCA61K45/00G01N33/6863G01N33/6866G01N2333/523G01N2333/555G01N2800/52
Inventor 崔龙王光辉傅佶泓刘辰莹刘云
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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