69 results about "Colorectal Tumors" patented technology

The present invention relates to methods and kits for the detection of predetermined biomarkers for early diagnosis and management of cancer, and in particular, colorectal tumors.

The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals having a colorectal neoplasm by detecting the presence of exfoliated epithelial markers (e.g., human DNA, tumor assoicated gene alterations, tumor associated proteins) and blood markers (e.g., homoglobin, serum proteins) in a stool sample obtained from the mammal.

The invention provides convenient food for conditioning colorectal neoplasms. L-glutamine acts as the main material of the convenient food, and according to the constitutive characters of patients suffering from colorectal neoplasms, the convenient food is prepared by the steps of reasonably and specifically blending food and drug herbal extracts, such as dendrobe, semen coicis, jerusalem artichoke, Chinese yam, dandelion, hawthorn, ficus carica L, honeysuckle, endothelium corneum gigeriae galli, hericium erinaceus, sea-buckthorn, fingered citron, medlar, semen raphani, pawpaw, apricot kernels, raspberry, portulaca oleracea and fructus amomi by utilizing the essence of the theory of traditional Chinese medicine, extracting the herbal extracts by a biological enzymolysis or prehydrolysis SBE technique, and then adding prebiotics, ammonia acids, oligopeptide, vitamins and minerals and mixing so as to prepare the convenient food. The convenient food prepared according to the formula provided by the invention is easy to dissolve, can be absorbed and utilized rapidly, can improve the nutritional condition of the patients suffering from colorectal neoplasms, can be used for assisting in improving the organism immunity by the effect of the bioactive components in the food and drug herbal extracts, plays roles of inhibiting and resisting cancers, and is suitable for patients suffering from colorectal neoplasms or patients which suffering from cancers and receiving radiotherapy or chemotherapy to eat, and therefore, the convenient food has the unique advantage of integrating the three efficacies of dietary therapy, prevention and conditioning.

Disclosed is a method for detecting colorectal tumor, particularly advanced adenoma and early cancer, in which a component contained in feces is employed as a measure. Specifically disclosed is a colorectal tumor detection method using a marker gene, which comprises the steps of (A) extracting RNA from feces collected from a subject, (B) measuring the amount of RNA derived from the marker gene contained in the RNA that has been obtained in step (A), and (C) comparing the amount of the RNA derived from the marker gene which has been measured in step (B) with a threshold value that has been determined previously depending on the type of the marker gene, and which is characterized in that the marker gene is CKB (creatine kinase B) gene.

Immune context scores are calculated for stage IV colorectal tumor tissue samples using non-continuous scoring functions. Feature metrics for at least one immune cell marker are calculated for a region or regions of interest, the feature metrics including at least a density of human CD8+ cells in a region of interest including a tumor core to generate an immune context score. The immune context score can then be used as a predictive metric (e.g. likelihood of response to a particular treatment course). The immune context score may then be incorporated into diagnostic and / or treatment decisions.