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A traditional Chinese medicine composition preventing and treating colorectal precancerous lesion, a preparing method thereof and applications of the composition

A technology for colorectal cancer and composition, which is applied in the directions of drug combination, medical preparation containing active ingredients, pharmaceutical formula, etc., to achieve the effect of safe use, prevention and treatment of colorectal cancer and no toxic and side effects

Inactive Publication Date: 2018-01-09
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The drugs currently used for the treatment of CRC are mainly chemical drugs, such as oxaliplatin, fluorouracil, irinotecan, folic acid, and bevacizumab. less than 30%

Method used

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  • A traditional Chinese medicine composition preventing and treating colorectal precancerous lesion, a preparing method thereof and applications of the composition
  • A traditional Chinese medicine composition preventing and treating colorectal precancerous lesion, a preparing method thereof and applications of the composition
  • A traditional Chinese medicine composition preventing and treating colorectal precancerous lesion, a preparing method thereof and applications of the composition

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Experimental program
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Embodiment 1

[0026] A preparation method of a traditional Chinese medicine composition for preventing and treating colorectal precancerous lesions, comprising the following steps:

[0027] Take 20 parts of Hedyotis diffusa, 9 parts of Sophora flavescens, 15 parts of Codonopsis pilosula, 12 parts of Atractylodes macrocephala, 12 parts of black plum, 3 parts of Coptis chinensis, 6 parts of paojiang, 30 parts of coix seed, add 8 times the amount of water respectively, and use decoction Extracted 3 times, 2 hours each time, filtered, combined extracts, concentrated to obtain extract.

Embodiment 2

[0029] A preparation method of a traditional Chinese medicine composition for preventing and treating colorectal precancerous lesions, comprising the following steps:

[0030] Take 20 parts of Hedyotis diffusa, 9 parts of Sophora flavescens, 15 parts of Codonopsis pilosula, 12 parts of Atractylodes macrocephala, 12 parts of black plum, 3 parts of Coptis chinensis, 6 parts of paojiang, 30 parts of coix seed, 15 parts of Agrimony, 15 parts of Scutellaria barbata, Add 12 times the amount of water to 9 parts of Tsubaki bark and 9 parts of Arrowhead mushroom, respectively, use reflux to extract 3 times, each time for 1.5 hours, filter, combine the extracts, and concentrate to obtain the extract.

Embodiment 3

[0032] A preparation method of a traditional Chinese medicine composition for preventing and treating colorectal precancerous lesions, comprising the following steps:

[0033] 40 parts of Hedyotis diffusa, 18 parts of Sophora flavescens, 30 parts of Codonopsis pilosula, 24 parts of Atractylodes macrocephala, 24 parts of black plum, 6 parts of coptis, 6 parts of paojiang, 60 parts of coix seed, 30 parts of Agrimony, 30 parts of Scutellaria barbata, 18 parts of skin, 18 parts of Shanzi mushroom. Add 10 times the amount of ethanol respectively, use ultrasonic extraction for 3 times, each time for 40 minutes, filter, combine the extracts, and concentrate to obtain the extract.

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Abstract

A traditional Chinese medicine composition preventing and treating colorectal precancerous lesion, a preparing method thereof and applications of the composition are disclosed. The composition includes 20-60 parts of hedyotis, 9-27 parts of lightyellow sophora root, 15-45 parts of radix codonopsis, 12-36 parts of largehead atractylodes rhizome, 12-36 parts of smoked plum, 3-9 parts of rhizoma coptidis, 6-18 parts of rhizoma zingiberis praeparatum and 30-90 parts of coix seed. Prescription screening is performed according to a traditional Chinese medicine theory that is treatment based on syndrome differentiation and according to pathogenesis of intestinal cancer. Treatment mechanisms of invigorating the spleen, benefiting qi, removing heat, drying dampness, detoxifying, removing stasis, and strengthening and consolidating body resistance are adopted innovatively. Experiment results show that the composition can obviously improve AOM-DSS induced symptoms such as body mass decrease, loose stool, and hemafecia, that the composition can reduce the occurrence rate of a colorectal lesion that is mouse colon tumor, and that the composition has significant activity resisting solid colorectal tumor and intestine cytoma. Disassembled prescription experiment results show that medicine materials of the composition are irreplaceable and the composition is a scientific prescription.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition capable of preventing and treating colorectal precancerous lesions and its application. Background technique [0002] Colorectal cancer (CRC), also known as colorectal cancer, is one of the most common malignant tumors of the digestive tract. More than one million people worldwide suffer from colorectal cancer every year and cause approximately 50 million deaths, accounting for the world's Malignant tumors rank fourth in the death rate. At present, the incidence of colorectal cancer in my country is on the rise, and the domestic incidence rate is 2% higher than the international level. [0003] The drugs currently used for the treatment of CRC are mainly chemical drugs, such as oxaliplatin, fluorouracil, irinotecan, folic acid, and bevacizumab. Less than 30%. Early diagnosis and precancerous prevention have become the main s...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P35/00
Inventor 程海波周仲瑛沈卫星李柳孙东东苗筠杰谭佳妮徐长亮
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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